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Essays on Life Itself: A Review of Robert Rosen's Legacy

Robert Rosen was an American theoretical biologist and professor of biophysics who made significant contributions to the understanding of the nature of life and the foundations of science. He is best known for his book Life Itself, which challenges the reductionist approach to biology and proposes a new framework based on relational and functional concepts. In his later book Essays on Life Itself, he expands on his ideas and addresses various topics related to life, complexity, causality, and epistemology.

In this article, I will review some of the main themes and arguments of Essays on Life Itself and discuss their implications for biology and philosophy. I will also highlight some of the strengths and weaknesses of Rosen's approach and suggest some directions for future research.

What is life?

One of the central questions that Rosen tackles in his essays is: what is life? He argues that this question cannot be answered by simply listing the properties or functions of living systems, such as metabolism, reproduction, or adaptation. Rather, he proposes a formal definition of life based on the notion of a closed causal loop. A closed causal loop is a system that produces its own components through a network of processes that are both efficient (material) and final (functional). In other words, a living system is one that makes itself.

This definition implies that living systems are fundamentally different from non-living systems, such as machines or crystals. Non-living systems are open causal chains that depend on external causes and effects for their existence and behavior. Living systems, on the other hand, are closed causal loops that generate their own causes and effects internally. This means that living systems are autonomous, self-referential, and irreducible. They cannot be fully explained or predicted by the laws of physics or chemistry alone, nor can they be decomposed into simpler parts without losing their identity.

What is science?

Another question that Rosen addresses in his essays is: what is science? He argues that science is not a collection of facts or theories, but a way of modeling reality. He defines a model as a mapping between two sets: a natural system (the object) and a formal system (the observer). A model is valid if it preserves some aspects of the structure or behavior of the natural system in the formal system. A model is useful if it allows us to make predictions or interventions on the natural system.

Rosen criticizes the dominant paradigm of science, which he calls mechanism, for being too narrow and restrictive. Mechanism assumes that all natural systems can be modeled by formal systems that are computable, deterministic, and reversible. Mechanism also assumes that all models can be tested by empirical observation and falsification. Rosen argues that these assumptions are not valid for all natural systems, especially living systems. He proposes an alternative paradigm, which he calls organicism, for modeling living systems. Organicism allows for formal systems that are non-computable, indeterministic, and irreversible. Organicism also allows for models that are not directly testable by observation, but by logical consistency and coherence.

What are the implications?

Rosen's essays have profound implications for biology and philosophy. They challenge some of the fundamental assumptions and methods of modern science and offer new perspectives and possibilities for understanding life. They also raise new questions and problems that require further investigation and exploration.

Some of the implications are:


The nature of life: Rosen's definition of life as a closed causal loop implies that life is not a property or a function, but a relation or a process. It also implies that life is not a matter of degree, but of kind. There is no continuum between living and non-living systems, but a qualitative difference. This raises questions about how to identify and classify living systems, how to measure their complexity and diversity, how to explain their origin and evolution, and how to interact with them ethically and responsibly.

The nature of science: Rosen's conception of science as a way of modeling reality implies that science is not objective or universal, but subjective and contextual 66dfd1ed39

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