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Our Mission
Our Mission
To improve the treatment of respiratory and neurological diseases and disorders through the development and use of innovative and adaptable technologies and methods leading to pharmaceutical aerosol products with high-efficacy and aerosol-targeting platforms with broad applicability.
Organization and Focus Areas
Organization and Focus Areas
Technologies
Technologies
Strategies for targeted drug delivery
Device platforms (e.g., high dose dry powder inhalers; pediatric; small particle aerosols; nasal targeting)
Formulation platforms (novel carrier particles; excipient enhanced growth)
Methods
Methods
Computational Fluid Dynamics (CFD) and CFD- pharmacokinetic modeling (CFD-PK)
Device fabrication and testing
Spray drying
Realistic in vitro and in vivo testing
Theme 1
Theme 1
Therapies that Address Lung Surfactant Deficiency and Damage
Neonatal respiratory distress syndrome (RDS)
Adult and pediatric acute respiratory distress syndrome (ARDS) and ALI
Medical Countermeasures (MCMs)
Theme 2
Theme 2
Therapies that Address Respiratory Infections and Inflammation
Antivirals, Antibiotics and Vaccines
Surfactant carrier particles
Medical Counter Measures (MCMs)
Theme 3
Theme 3
Therapies that Address Chronic Respiratory and Neurological Conditions
Respiratory: Bronchopulmonary dysplasia (BPD) and Idiopathic pulmonary fibrosis (IPF)
Neurologic: Nasally targeted delivery and Glymphatic clearance
Theme 4
Theme 4
Advancing Regulatory Science of Medical Aerosols
Use of Computational Fluid Dynamics (CFD) and CFD-PK models
CFD-Bio modeling
Use of realistic in vitro airway models
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