The barriers to equality are deeply ingrained and complex. Overcoming them will not be easy. However, we believe that when women and girls are empowered to live to their full potential, everyone benefits exponentially. Efforts to improve the health and well-being of those most in need will become much more achievable when we put the empowerment of women and girls at the heart of sustainable development. As Melinda Gates wrote in 2014, “We will not use the complexity of resolving gender inequality as an excuse for failing to think and act more intentionally about putting women and girls at the center of what we do.”