When taken at the correct dose, ibuprofen is safe and effective for both children and adults. However, it is important to be aware of the maximum dosage of ibuprofen. At large doses, ibuprofen can cause serious adverse effects and may even be fatal. Notably, studies have shown that among all analgesic (pain-reliever) overdoses, nearly one-third included ibuprofen, making ibuprofen the most common NSAID involved in an overdose.