Using lithography, I created a novel thin-film resitive heater that acts as its own thermometer. This means that you can locally change the temperature in the vicinity of local heater. We are able to cycle the temperature between 20°C and 30°C degrees 1000 times a second!
This is used create fast molecular machines, based on DNA hybridization and dehybridization. We reversibly control a DNA machine in the form of a semi-flexible hinge, folding at low temperatures(~20°C) and opening at elevated temperatures (~30°C). Our design enables control of molecular motors using DNA hybridization and crucially, allows for the synchronization of hybridization and melting of multiple DNA machines working together.
PUBLICATIONS:
1) K. Wang, A.V. Hardikar,W. Chen, Q. Huang, B. Guo, G. Zhu, R. Sha, N. Seeman, P.M. Chaikin. Control and synchronization of DNA Machines by Local Heating, Submitted
2) A.V. Hardikar, K. Wang, H. Ni, R. Sha, P.M. Chaikin. DNA Origami Arm Powered by a Local Heater. Bulletin of the American Physical Society, 2023
We created artificial microscopic robots or active swimmers powered solely by light, use no chemical fuel, and essentially go on forever!
This is done by attaching a oil droplet (light part in image) to a magnetic bead (dark part in image). The dark bead absorbs light and heats up, creating a temperature gradient that propels the swimmer forward due to an effect called thermophoresis.
Multiple swimmers together, exhibit behavior that is unique to active systems such as swarming in flocks of birds and in school of fish. This special kind of matter also exhibits motility induced phase separation, creating a dense cluster of swimmers that changes shape, allowing to verification of several theories in the field of active matter.
PUBLICATIONS:
1) Hardikar, A. V., Ben Zion, M. Y., Hollingsworth, A., Chaikin, P.M. (2022). Fuel-free light-driven colloidal swimmers. APS March Meeting Abstracts (Vol. 2022, pp. W20-012)
References:
Zhiyuan Fan and Alexander O Govorov. Plasmonic circular dichroism of chiral metal nanoparticle assemblies. Nano letters, 10(7):2580–2587, 2010.
Hyeon-Ho Jeong, Andrew G Mark, Mariana Alarc ́on-Correa, Insook Kim, Peter Oswald, Tung-Chun Lee, and Peer Fischer. Dispersion and shape engineered plasmonic nanosensors. Nature communications, 7:11331, 2016.
References:
Van Oudheusden, B. W. (2013): 032001.
Agrawal, Amit, Rama Chellappa, and Ramesh Raskar. "An algebraic approach to surface reconstruction from gradient fields." Computer Vision, 2005. ICCV 2005. Tenth IEEE International Conference on. Vol. 1. IEEE, 2005.
Maass C C, Krüger C, Herminghaus S, Bahr C. 2016 Annu. Rev. Condens. Matter Phys. 7:171–193
References:
Self-replicating colloidal clusters PNAS 2014 1748-23 Zeravcic, Brenner
Mutation at Expanding Front of Self-Replicating Colloidal Clusters. July 21, 2016 Tanaka, Zeravcic, Brenner
Algorithmic Self-assembly of DNA. Thesis by Eric Winfree
Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity PNAS August 6, 1974 Hopfield
References:
Quantum Physics by Stephen Gasiorowicz
Mathematical Methods in the Physical Sciences by Mary L. Boas
Introduction to Quantum Mechanics by David Griffiths