Research

We apply the nanopatterned 2D hPSC-CM monolayer for understanding cardiac electrical and mechanical couplings; micropatterned single hPSC-cardiomyocyte for modeling familial cardiomyopathies, micropatterned cardiac microfiber for hPSC-CM maturation in calcium handling and T-tubule formation; micropatterned 3D cardiovascular organoid for modeling heart development, drug-induced and environment-caused birth defects, and congenital heart diseases.

We apply various interventions for assisting cardiovascular repair, such as acellular therapy with microRNA (miRNA), nanoparticle and injectable hydrogel for improving cardiac function; NIR-II small molecule with high quantum yield and sensitivity for in vivo stem cell tracking and quantification in long term; and 3D bioprinting for cardiovascular remuscularization and revascularization.

We apply soft lithography, 3D printing, and macro/microfluidics for biofabricating biomedical microdevices for better understanding the developments of cardiovascular pathophysiology.