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Cavitation (volume oscillations and collapse of gas bubbles), as generated by a co-administration of shockwaves (SW) and microbubbles (SWB), induces cytotoxicity in vitro. Moreover, cavitation potentiates the effects of Fluorouracil (FUra) on colon cancer cells. We aimed at reproducing such effects in vivo. A peritoneal carcinomatosis was induced in BDIX rats by intraperitoneal (IP) injection of DHDK12PROb cells. Cavitation was produced by various SW regimens (250 to 750SW) combined with bubbles (air/gelatin emulsion) infused through an IP catheter. In two consecutive experiments, microtumours (day 3 after cell injection) were submitted to various combinations of cavitation and/or Fluorouracil (FUra) and Cisplatinum (CDDP) at either high or low doses. After 30 days, 100% of control animals were dead or presented carcinomatosis with ascites, vs 60% after FUra 5 mg kg dy, day 4 through 8, and 0% after 250 SWB, day 4 and 6 + FUra 5 mg kg dy, day 4 through 8 (P < 0.001); similar differences were found with CDDP. Survival after low dose FUra + SWB was comparable to high dose FUra (25 mg kg dy day through 8) and was improved as compared to low-dose FUra alone. Only a high dose FUra + SWB schedule induced 40% long term (> 150 days) disease-free survival, but also a higher undesirable toxicity (40% toxic deaths within 1 month). It is concluded that cavitation is cytotoxic in vivo and that it potentiates the effects of FUra and CDDP in this animal model.

The aim of this work was to report our own clinical experience and to compare it our results with those already published. This is a retrospective study of 70 splenectomies performed for hematologic diseases at the service des urgences viscerales of Ibn Rochd teaching hospital of Casablanca, between 1996 and 2001. The study included 70 patients. Splenectomy was performed for therapeutic reasons by laparotomy in 56 cases (80%) and bym laparoscopy in 14 cases (20%). The post-operative after-effects were mild in 81.4%. A patient died, however of pulmonary embolism. Splenectomy is an important tool in the management of patients suffering from hemolytic anemia, auto-immune thrombopenic purpura and other hemolytic anemias. Management by a multidisciplinary team is required to prevent a maximum of long and short-term post-operative complications and to offer the offer the best conditions for a successful splenectomy.

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In this work, we study the vibration of, and wave propagation in, a periodically laminated composite slab. Special emphasis is given to the long time behavior of the vibration. It is found that a phase shift phenomenon occurs as a result of the interaction of the disturbance with the microstructure and the boundaries of the slab. We provide an asymptotic analysis to explain this phenomenon which we also illustrate by numerical calculations.

It's surely the best time of year to be in a European city. The birds are singing in the parks, the days are growing longer, and the temperatures, for the most part, are just perfect, neither too hot, nor too cold.

First of all thank you for the amazing script it work amazingly, I have a similar set up to what was requested by Fadil, except there is only one difference, in my set up I have a folder that contains files that are submitted by a third party which I have configured a task schedule to move them to another folder.This parent folder has subfolders inside it, so when i apply the script (or test it), since it has a bit too many subfolders, it takes very long time to finish running the script which also takes from the performance of the server.so, how can I make it that the script only checks the "files" in the parent folder and not check the "subfolders" in the parent folder.There is the option of just moving these files to a folder where they will be alone there with no subfolders but unfortunately it is set up like this from the application side too which would be a lot of work to change it from the application side.thank you in advance.

Since the defendants did not face successive trials for their arguably overlapping conspiracies, Hampton-El's double jeopardy argument is governed by the standard Blockburger analysis, which allows separate punishment for two offenses as long as each requires some distinct element of proof. See Blockburger v. United States, 284 U.S. 299, 304 (1932); United States v. Avelino, 967 F.2d 815, 816 (2d Cir. 1992). Hampton-El appears to concede that his challenge would be unavailing under Blockburger because the seditious conspiracy, the bombing conspiracy, and the attempted destruction of property offenses each has elements not contained in the other offenses. 17dc91bb1f