Research

Research Overview

We are developing advanced biologics delivery technologies to help those suffering from diseases through multidisciplinary research based on integrative biotechnology knowledge. We are mainly focusing on exploring the challenges in the biomedical fields that are difficult to solve and trying to develop advanced technologies to overcome the current limitations by utilizing the knowledge from multidisciplinary research fields such as Biotechnology, Material Engineering, Chemical Engineering, and Immunology.

저희 연구팀은 융합 생명공학 지식에 기반한 다학제적인 연구를 통해서 질병으로 고통받고 있는 이들을 돕기 위한 첨단 바이오의약품 전달 기술들을 개발하고 있습니다. 의생명 분야에서 풀기 어려운 문제들을 탐색하고, 생명공학, 재료공학, 화학공학, 면역학과 같은 다학제적 연구분야의 지식을 활용하여 그 한계들을 극복할 수 있는 첨단기술들을 개발하기 위해 노력하고 있습니다.

Advanced Materials for Biomedical Applications

As the field of biomedical engineering has become more precise and sophisticated, the demand for highly-functionalized biomaterials has risen. In particular, novel organic/inorganic hybrid biomaterials with two or more chemical, physical, and optical properties are currently being developed and applied in various biomedical fields. Now we are focusing on the development of advanced materials using organic/inorganic hybridization. The nanoparticular hybrid materials can be applied to drug delivery, biomedical imaging, cancer immunotherapy, photomedicine, and gene editing, while the hybrid nanocomposites can be utilized to scaffolds for tissue engineering, vascular implants, and dental implants.

Biomaterials for Cancer Immunotherapy

Recently, cancer immunotherapy has received attention as a viable solution for the treatment of refractory tumors. However, it still has clinical limitations in its treatment efficacy due to inter-patient tumor heterogeneity and immunosuppressive tumor microenvironment (TME). Biomaterial-based approaches can be powerful tools for this purpose, as biomaterials allow us to deliver a variety of immunotherapeutic agents at the right time and place. Now we are developing new strategies for cancer immunotherapy using advanced biomaterials.

Image-guided Therapy

In interventional oncology, a field derived from interventional radiology, image guidance is used to diagnose and treat cancer in a minimally invasive fashion. Local delivery of therapeutics to tumors located in various organs can be achieved through the use of medical imaging devices such as X-rays, ultrasound, computed tomography (CT), fluorescent optical imaging, or magnetic resonance imaging (MRI) in conjunction with minimally invasive intravascular catheters or biopsy needles. The benefits of image-guided local therapy include a dramatic reduction in drug dose, which in turn ameliorates side effects, promotes rapid recovery, and decreases cost. Due to their inherent physicochemical properties, nanoparticles have been used in the development of multiple imaging agents. Now we are developing functional biomaterials based on nanoparticles for image-guided therapy.

Journal Covers

Our research has been highlighted on the covers of leading journals in the biomedical field, including Advanced Functional Materials, Advanced Healthcare Materials, Small, Advanced Science, Biomaterials Science and Exploration.

Selected Publications

Biomimetic lipid nanoparticles for macrophage reprogramming in cancer immunotherapy. Journal of Controlled Release (2026)

Synergistic immunotherapeutic effects of irreversible electroporation and anti-GPC3 CAR-NK cell therapy against hepatocellular carcinoma. Signal Transduction and Targeted Therapy (2026)

Transforming lipid nanoparticles into radio-activatable therapeutics through synergistic ferroptosis. Biomaterials (2026)

Photosensitizing lipid nanoparticles for ferroptosis-enhanced photodynamic therapy via GPX4 silencing. Advanced Healthcare Materials (2025)

Lipid nanoparticles target neutrophils to reduce SARS-CoV-2-induced lung injury. Journal of Controlled Release (2025)

Advanced hybrid nanomaterials for biomedical applications. Progress in Materials Science (2020)

Full publication list (Google Scholar)

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