We investigate mesenchymal stem/stromal cells (MSCs) and their secreted extracellular vesicles, exosomes, and EVs, as potential therapies for autoimmune and degenerative diseases, including Type 1 Diabetes (T1D). Our work probes the mechanisms of MSC-mediated immunomodulation and tissue repair, and develops cell-free therapeutic strategies by combining in vitro studies, in vivo disease models, and biomaterials-based approaches.

• MSC-mediated immunomodulation

• MSC-derived exosomes & extracellular vesicles (EVs)

• Cell-free therapeutic strategies

• Tissue repair mechanisms

• In vivo models of autoimmune disease (incl. T1D)

• Biomaterials-based delivery of MSC/EV therapeutics