Publications
Inez K. A. Pranoto and Young V. Kwon
STAR Protocols (2024)
Comparative Interactome Analysis of α-arrestin Families in Human and Drosophila
Kyungtae Lee*, Inez K.A. Pranoto*, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V. Kwon#, and Jin-Wu Nam#
eLife (2024)
Inez K.A. Pranoto, Jiae Lee, and Young V. Kwon
Cell Reports (2023)
Remodeling of E-cadherin Subcellular Localization during Cell Dissemination.
Alejandra J.H. Cabrera, Barry M. Gumbiner, and Young V. Kwon
MBoC (2023)
Wear and Tear of the Intestinal Visceral Musculature by Intrinsic and Extrinsic Factors.
Ho Dam Kim*, Eric So*, Jiae Lee*, Yi Wang, Vikram S. Gill, Anna Gorbacheva, Hee Jin Han, Katelyn G.-L. Ng, Ken Ning, Inez K.A. Pranoto, Alejandra J.H. Cabrera, Dae Seok Eom, and Young V. Kwon
Developmental Dynamics (2022)
Our undergraduate students discover four gut visceral muscle pattern disruption phenotypes, which can serve as quantitative markers of the wear and tear of a tissue structure during aging and under various stresses in Drosophila.
Paeonia lactiflora extract improves the muscle function of mdx mice, an animal model of Duchenne muscular dystrophy, via downregulating the high mobility group box 1 protein.
Inae Sim, Jaewoong Jang, Jaewon Song, Jongkyu Lee, Hyemi Lim, Hyun Jung Lee, Syusik Hwang, Young V. Kwon, Doheon Lee, and Yoosik Yoon.
J. Ethnopharmacol. (2022)
The roles of distinct calcium signaling mediated by Piezo and inositol triphosphate receptor (IP3R) in the remodeling of E-cadherin during cell dissemination.
Alejandra J.H. Cabrera, Barry M. Gumbiner, and Young V. Kwon
bioRxiv (2021)
Wnt-Signaling Inhibitor Wnt-C59 Suppresses the Cytokine Upregulation in Multiple Organs of Lipopolysaccharide-Induced Endotoxemic Mice via Reducing the Interaction between β-Catenin and NF-κB.
Jaewoong Jang, Jaewon Song, Inae Sim , Young V. Kwon, and Yoosik Yoon
Int J Mol Sci (2021)
Tumors Overcome the Action of the wasting factor ImpL2 by Locally Elevating Wnt/Wingless.
Jiae Lee, Katelyn G.-L. Ng, Kenneth M. Dombek, and Young V. Kwon.
PNAS (2021)
In the manuscript, we employ our Drosophila model of cachexia-like wasting to address how tumors evade self-wasting.
LGK974 suppresses lipopolysaccharide-induced endotoxaemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways.
Jaewoong Jang, Jaewon Song, Hyunji Lee, Inae Sim, Young V. Kwon, Eek-hoon Jho, and Yoosik Yoon.
Experimental & Molecular Medicine (2021)
Paeonia lactiflora extract suppresses cisplatin-induced muscle wasting via downregulation of muscle-specific ubiquitin E3 ligases, NF-κB signaling, and cytokine levels.
Jaewoong Jang, Jaewon Song, Hyunji Lee, Inae Sim, Young V. Kwon, Eek-hoon Jho, and Yoosik Yoon.
Journal of Ethnopharmacology (2020)
Dissemination of RasV12-trasformed cells requires the mechanosensitive channel Piezo.
Jiae Lee*, Alejandra Cabrera*, Cecilia Nguyen and Young V. Kwon (*equal contribution)
Nature Communications (2020)
We describe our Drosophila model of cell dissemination.
The Role of Translationally Controlled Tumor Protein (TCTP) in Proliferation of Drosophila Intestinal Stem Cells.
Young V. Kwon*, Bingqing Zhao, Chiwei Xu, Jiae Lee, Chiao-Lin Chen, Arunachalam Vinayagam, Bruce A. Edgar, and Norbert Perrimon* (*corresponding authors)
PNAS (2019)
Drosophila melanogaster as a Model of Muscle Degenerative Disorders.
Kreipke RE, Kwon YV, Shcherbata HR, Ruohola-Baker H.
Current Topics in Developmental Biology (2017)
Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets.
Vinayagam A, Gibson TE, Lee HJ, Yilmazel B, Roesel C, Hu Y, Kwon Y, Sharma A, Liu YY, Perrimon N, Barabási AL.
PNAS (2016)
Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2.
Kwon Y, Song W, Droujinine IA, Hu Y, Asara JM and Perrimon N.
Developmental Cell (2015) April 6;33:36-46
This article describes the systemic organ wasting process in Drosophila.
Highlighted in the following articles:
Insulin interference triggers Cancer-linked Cachexia. Jyoti Madhusoodanan. The Scientist (2015)
Wasting away without insulin. Annalisa M. Vanhook. Science Signalig (2015)
Origin of cancer wasting identified in fruit flies. Eurekalert (2015)
A waste of insulin interference. Erwin F. Wagner & Michele Petruzzelli. Nature (2015)
The Hippo signaling pathway interactome.
Kwon Y, Vinayagam A, Sun X, Dephoure N, Gygi SP, Hong P and Perrimon N.
Science (2013) Nov 8;343(6159):737-40
Highlighted in the following articles:
Ray LB. Sci Signal (2013) Dissecting Hippo interactions
Weiss EL. Sci Signal (2013) Hippo unleashed! Proteome-scale analysis reveals new biews of Hippo pathway biology.
Moya Im, Halder G. Cell Research (2013) Dicovering the Hippo pathway protein-protein interactome.
PPIRank - an advanced method for ranking protein-protein interactions in TAP/MS data.
Sun X, Hong P, Kulkarni M, Kwon Y, Perrimon N.
Proteome Sci.(2013) Nov 7;11(Suppl 1):S16.
Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes.
Neumuller RA*, Wirtz-Peitz F*, Lee S, Kwon Y, Buckner M, Hoskins RA, Venken KJT, Bellen HJ, Mohr SE and Perrimon N.
Genetics (2012) Mar;190(3):931-40.
False negative rates in Drosophila cell-based RNAi screens: A case study.
Booker M, Samsonova AA, Kwon Y, Flockhart I, Mohr SE, Perrimon N.
BMC Genomics. (2011) Jan 20;12(1):50.
Shen WL, Kwon Y, Adegbola AA, Luo J, Chess A and Montell C. Rhodopsin required for temperature discrimination. Science (2011) Mar 11;331(6022):1333-6.
Kwon Y, Kim SH, Ronderos DS, Lee Y, Akitake B, Woodward OM, Guggino WB, Smith DP, Montell C. Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol. (2010)
Kwon Y*, Shen WL*, Shim HS, Montell C. Fine thermotactic discrimination between the optimal and slightly cooler temperatures via a TRPV channel in chordotonal neurons. J Neurosci. (2010)
Kwon Y, Shim HS, Wang X, Montell C. Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat Neurosci. (2008)
Kwon Y, Hofmann T, Montell C. Integration of phosphoinositide and calmodulin mediated regulation of TRPC6. Mol Cell. (2007) 25:491-503
Kwon Y, Montell C. Dependence on the lazaro phosphatidic acid phosphatase for the maximum light response. Curr Biol. (2006) 16:723-9.