Heshmati Research Group

Neurobiology of anesthesia, stress and delirium 


Several overarching questions guide our research: 

(1) What is the emotional experience of emergence from general anesthesia? 

(2) How does the experience of stress, or pain, modify behavior? 

(3) What is the neurobiology of stress and delirium across the lifespan?

Importantly, how can we apply preclinical knowledge to improving patient experiences?

Current Projects

Whole brain activity mapping of general anesthesia and emergence

Role of neuroligin-2 in pain, stress and agitated behavior 

Neural circuit studies of emergence and sites of anesthetic action

Applying wireless mechanoacoustic devices for peripheral physiologic recordings in mice

Collaboration with NeuroLux, Inc 

Meet the Team

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Mitra Heshmati, MD, PhD

Principal Investigator

Attending Anesthesiologist, University of Washington Medical Center-Montlake

I am a physician-scientist with a research background focused on nucleus accumbens neural circuitry and a clinical practice in Anesthesiology, bringing my preclinical research and clinical interests together to understand how anesthetics affect stress, pain, and arousal circuitry to modify behavior.


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Ainsley Barrow

Research Technologist

 I graduated from the University of Washington in 2023 with a Bachelor of Science degree in Neuroscience and was initially drawn to the field after working with patients with neurodegenerative disorders. Throughout my undergraduate career, I became more interested in the neural mechanisms behind psychiatric disorders and behavior, which attracted me to the lab. 


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Carlee Toddes, PhD

Postdoctoral Scientist, Weill Neurohub Fellow 

Primary appointment in the Golden Laboratory, co-mentored by Dr. Heshmati

I am a postdoctoral research fellow specializing in the study of neural dynamics underlying pain-modulated social behavior. I obtained my Ph.D. from the University of Minnesota, where I conducted research in the Rothwell Lab investigating opioidergic mechanisms that underlie social affiliative behaviors. Beyond my laboratory work, I am deeply committed to promoting positive change in the scientific community through active involvement in science policy and advocacy.  


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Ella Apley

Undergraduate Student 

I am a current sophomore hoping to study biochemistry at the University of Washington. After I graduate, I plan on attending graduate school and pursuing a career in medicine or biological sciences. Besides research, I love spending time with my friends, hiking, and traveling outside of Washington State! 



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Riley Keeler

Undergraduate Student 

I am currently an undergraduate student at the University of Washington studying Biochemistry. Following graduation I plan to work as a ski patroller and then attend medical school with hopes of becoming a surgeon. Within lab I am interested in understanding chronic pain with hopes of finding effective treatment approaches. 


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Silvana Segura

Undergraduate Student 

I am currently a Psychology student at the University of Washington, interested in cognitive disorders, behavior, and clinical applications of wet lab research. In the future I hope to attend medical school, and find a specialty in medicine I am passionate about. Aside from my interests in psychology and neuroscience, I love music and also sing in the UW Chorale choir.  


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Jason Zhang

Undergraduate Student 

I am currently majoring in Biochemistry along with two additional minors. I hope to pursue a career in medicine specializing in anesthesiology. Outside of the lab, I enjoy spending time with friends and family as well as learning niche skills. 


Lab Alumni

Research Technologists/Scientists

Alexandria Murry, 2021-23

Rachael Hansen, 2023-24


Undergraduate Student Researchers 

Natalie Hoffman, graduated 2022

Aasiya Islam, graduated 2022

Kayla Pitts, graduated 2022

WE'RE HIRING! We have openings for postdoctoral fellows, graduate students, or undergraduate students to join the team... email mhesh@uw.edu with your CV, research experience and interests.


Come visit us in the Health Sciences Building !

The laboratory is located on the 5th floor of F-wing



Funding & Support

FAER Mentored Research Training Grant, 2021-2022

R35/Maximizing Investigators' Research Award, 2022-2027

(Heshmati, Principal Investigator)

R43/Small Business Innovation Research Grant, 2022-2023

(Heshmati, Subaward Co-Investigator)