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Tissue Regeneration through Exosome Engineering
Tissue Regeneration through Exosome Engineering
Our precision porous scaffolds promote exquisite healing through the exclusive intermingling of specific T cells and M1-macrophage phenotypes that generate exosomes with unique miRNA and protein content capable of re-programming cells into desired tissue cells (trans-differentiation). NIH - 5R01GM128991-02.
Our precision porous scaffolds promote exquisite healing through the exclusive intermingling of specific T cells and M1-macrophage phenotypes that generate exosomes with unique miRNA and protein content capable of re-programming cells into desired tissue cells (trans-differentiation). NIH - 5R01GM128991-02.
Buddy D. Ratner, Ph.D.
Buddy D. Ratner, Ph.D.
Professor, Departments of Bioengineering and Chemical Engineering
Professor, Departments of Bioengineering and Chemical Engineering
Jay Heinecke, Ph.D.
Jay Heinecke, Ph.D.
Professor, Department of Medicine
Professor, Department of Medicine
Functional Amyloid Formation in Bacteria
Functional Amyloid Formation in Bacteria
Biofilm are microorganisms entrapped in a 3D extracellular matrix (ECM) of their own making; the ECM comprises extracellular polysaccharides, DNA, and proteins, the latter mostly in the form of amyloid fibrils. This project analyses the mechanism of amyloid formation in both Gram-positive and Gram-negative bacteria, introduces two different synthetic peptide design approaches to inhibit amyloid formation, and translates the results to clinically relevant models.
Biofilm are microorganisms entrapped in a 3D extracellular matrix (ECM) of their own making; the ECM comprises extracellular polysaccharides, DNA, and proteins, the latter mostly in the form of amyloid fibrils. This project analyses the mechanism of amyloid formation in both Gram-positive and Gram-negative bacteria, introduces two different synthetic peptide design approaches to inhibit amyloid formation, and translates the results to clinically relevant models.
Valerie Daggett, Ph.D
Valerie Daggett, Ph.D
Professor, Department of Bioengineering
Professor, Department of Bioengineering
Matt Parsek, Ph.D.
Matt Parsek, Ph.D.
Professor, Department of Microbiology
Professor, Department of Microbiology
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