In the Supra Sensors Stream (SMS), students acquire a unique set of skills taking on the challenge of constructing differential array sensors and applying Metabolomics as chemical tools to study molecules of biological interest in complex mixtures. SMS Students will acquire the following knowledge and skillsets including 1) learning how to identify and write complex organic chemical structures, 2) understanding how to design and synthesize peptide-based sensors, 3) understanding what differential sensing is and how is implemented, 4) learning how to quantify sensor-analyte interactions (e.g., absorption and mass spectrometry) 5) learning how to synthesize, purify and characterize sensors and identify metabolites (e.g., liquid chromatography-mass spectrometry) and 6) learning how to process and analyze multivariate datasets using chemometrics/machine learning.