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The immune system employs a sophisticated array of molecular mechanisms to defend one's body against pathogens and maintain homeostasis.1 Central to long-term immune responses are antibodies, which play pivotal roles in antigen recognition and immune response orchestration.2
Antibodies are soluble proteins produced and released by B cells. They contain variable (Fab) regions that bind to a diverse variety of antigens, and constant (Fc) regions that bind to our immune cells through Fcy receptors (FcyRs) to induce various effector functions to act on the bound antigens.2 These effector functions include antibody-dependent phagocytosis (ADCP), antibody-dependent cellular cytotoxicity (ADCC), complement activation (CDC), toxin and antigen neutralization, and generation of a downstream pro- or anti-inflammatory immune response.3,4
This project aims to develop a tool that comprehensively characterizes antibodies in a simplified way based on their amino acid sequences. This would be useful in understanding the functional diversity of antibodies and their interactions with antigens, which is crucial for elucidating immune system dynamics and designing effective immunotherapeutic strategies. Connecting antibody amino acid sequences to certain characteristics can help develop novel antibody therapeutic engineering and further understanding of the importance of certain residues.
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