Publications

Efficient synthesis for each of the eight stereoisomers of the iminosugars lentiginosine and 1,4-dideoxy-1,4-imino-D-arabinitol (DAB)

Louis J. Liotta, Jessica Antoine, Leighanne A. Brammer Basta, Andrew S. Campbell, Gabrielle Y. Cole, Kristen A. Demick Brazile, Natalie M. Dogal Gardner, Megan E. Fitzgerald, Jean E.K. Francois, Brian M. French, Sara L. Garafola, Catherine A. Giannetti, Eve A. Granatosky, Alycen M. Harney, James T. Hummel, Andrew P. Joyce, Mitchell H. Keylor, Jasmine A. Khubchandani, Claudia Korzeniecki, Diana C. Lieberman, Joshua M. Litterio, Madison O. Maiorano, Jessica F. Marshall, Kelly A. McCarthy, Andreia Mendes Vieira, Ruby M. Miller, Emily R. Morrison, Steven P. Moura, Dillon F. Neumann, Aliza F. Oliveira, Nicholas J. Pace, Jodie X. Plouffe, Meredith N. Pomfret, Katelyn N. Reardon, Samantha M. Sheller-Miller, Michael J. Smith, Jessica L. Sullivan, Samantha W. Sweeney, Kerstin L. Tougas.

Carbohydr. Res. vol 545, 2024, pp. 109280.

Manipulating the 3D organization of the largest synthetic yeast chromosome

Weimin Zhang, Luciana Lazar-Stefanita, Hitoyoshi Yamashita, Michael J. Shen, Leslie A. Mitchell, Hikaru Kurasawa, Evgenii Lobzaev, Viola Fanfani, Max A.B. Haase, Xiaoji Sun, Qingwen Jiang, Gregory W. Goldberg, David M. Ichikawa, Stephanie L. Lauer, Laura H. McCulloch, Nicole Easo, S. Jiaming Lin, Brendan R. Camellato, Yinan Zhu, Jitong Cai, Zhuwei Xu, Yu Zhao, Maya Sacasa, The Build-A-Genome Class, Marcus B. Noyes, Joel S. Bader, Samuel Deutsch, Giovanni Stracquadanio, Yasunori Aizawa,* Junbiao Dai,* and Jef D. Boeke 

Molecular Cell, vol. 83, 2023, pp. 4424-4437

Prof. Basta led the Build-A-Genome class as an Affiliate Faculty member in the Biology Department at Loyola University and her students contributed to the chunk assembly of DNA.

Atypically modified carbapenem antibiotics display improved antimycobacterial activity in the absence of beta-lactamase inhibitors

Gupta R, Al-Kharji NMSA, Alqurafi MA, Nguyen TQ, Chai W, Quan P, Malhotra R, Simcox BS, Mortimer P, Brammer Basta LA*, Rohde KH*, Buynak, JD*

ACS Infect. Dis., vol. 7(8), 2021, pp. 2425-2436

Phylogenetic and biochemical analyses of mycobacterial LD-transpeptidases reveal a distinct enzyme class that is preferentially acylated by meropenem

Zandi TA, Marshburn RL, Stateler PK, Brammer Basta LA

ACS Infect. Dis., vol. 5(12), 2019, pp. 2047-2054

Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase LdtMt2 by biapenem and tebipenem

Bianchet MA, Pan YH, Brammer Basta LA, Saavedra H, Lloyd EP, Kumar P, Mattoo R, Townsend CA, Lamichhane G

BMC Biochem., vol. 18(1), 2017, p. 1

Loss of a functionally and structurally distinct LD-transpeptidase, LdtMt5, compromises cell wall integrity in Mycobacterium tuberculosis

Brammer Basta LA, Ghosh A, Pan Y, Jakoncic J, Lloyd EP, Townsend CA, Lamichhane G, Bianchet MA.

J. Biol. Chem., vol. 290(42), 2015, pp. 25670-25685

Defining critical residues for substrate binding to 1-deoxy-D-xylulose 5-phosphate synthase--active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate

Brammer Basta LA, Patel H, Kakalis L, Jordan F, Freel Meyers CL

FEBS J, vol. 281(12), 2014, pp. 2820-2837

Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of pyruvate decarboxylation by D-glyceraldehyde-3-phosphate

Patel H, Nemeria NS, Brammer LA, Freel Meyers CL, Jordan F

J. Am. Chem. Soc., vol. 134(44), 2012, pp. 18374-18379

1-Deoxy-D-xylulose 5-phosphate synthase catalyzes a novel random sequential mechanism

Brammer LA, Smith JM, Wade H, Freel Meyers CF

J. Biol. Chem., vol. 286(42), 2011, pp. 26522-36531

Revealing substrate promiscuity of 1-deoxy-D-xylulose 5-phosphate synthase

Brammer LA and Freel Meyers CL

Org. Lett., vol. 11(20), 2009, pp. 4748-4751

The binding and release of oxygen and hydrogen peroxide are directed by a hydrophobic tunnel in cholesterol oxidase

Chen L, Lyubimov AY, Brammer LA, Vrielink A, Sampson NS

Biochemistry, vol. 47(19), 2008, pp. 5368-5377

A target-unrelated peptide in an M13 phage display library traced to an advantageous mutation in the gene II ribosome-binding site

Brammer LA, Bolduc B, Kass JL, Felice KM, Noren CJ, Hall MF

Anal. Biochem., vol. 373(1), 2008, pp. 88-98