Embedded Files
8:30 - 9:00 am
Registration
Coffee and small Pastries
9:00 - 9:10 am
Welcome Remarks (Irene Chiolo)
9:10 am - 10:40 pm
Session 1: Break repair, telomere stability, and genome rearrangements (chair: Jeremy Stark)
Ksenia Krupina, Ph.D. (Don Cleveland's lab, UCSD): Chromothripsis and ecDNA induced by N4BP2 nuclease-mediated fragmentation of cytoplasm exposed chromosomes.
Anik Mitra (Irene Chiolo's lab, USC): Heterochromatin repair mechanisms: to transcribe or not to transcribe?
Peter Chovanec, PhD (Yi Yin's lab, UCLA): Characterizing genome instability events in mouse development by single-cell sequencing.
Tobias Schmidt, Ph.D. (Jan Karlseder’s lab, Salk Institute) Telomere dynamics in aging and cancer by Nanopore long-read sequencing.
Ning-Hsiang Hsu (Feng Qiao's lab, UCI): Shelterin bridge dimmer is formed by domain swapping and inhibits chromosome end fusion.
Liang Sha, Ph.D. (Yali Dou's lab, USC Keck): Non-canonical MLL1 activity regulates centromeric phase separation and genome stability.
10:40 - 12:30 pm
Poster Session
12:30 - 1:30 pm
Lunch (Meet Professors Career Development 1)
1:30 - 2:45 pm
Session 2: Mutagenesis (chair: Rémi Buisson)
Xiaomei He, Ph.D. (Yinsheng Wang's lab, UCR): Promoter R-loops Recruit U2AF1 to Modulate Its Phase Separation and RNA Splicing
Peini Hou, PhD (Dong Wang's lab, UCSD): Structural basis of transcriptional mutagenesis by FapydG lesions.
Quinn Cowan (Alexis Komor's lab, UCSD): Development and characterization of multiplexed orthogonal base editing systems.
Debika Ojha, PhD (Myron Goodman's lab, USC): The Multi-antibiotic Resistance Pandemic: An Essential Role for Pathogen-encoded DNA Polymerases in Accelerating the Acquisition of Antibiotic Resistance
Ambrocio Sanchez (Rémi Buisson lab, UCI): Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes.
2:45 - 3:15 pm
Coffee Break
3:15 - 4:30 pm
Session 3: Genome instability and Cancer (chair: Xiaohua Wu)
Katherine Roth, PhD (Stephen Gruber's lab, CHLA): Colibactin Mutational Signature in Colorectal Cancer.
Maria Altshuller (Daniel Semlow's lab, Caltech): The mechanism of colibactin-induced DNA interstrand cross-link repair.
Jessica Hess, Ph.D. (Binghui Shen's lab, CoH): Identification of Small Molecule Inhibitors of Exonuclease 1 for Breast Cancer Treatment.
Valeria Rangel (Nick Pannunzio's lab, UCI): Increased AID Results in Mutations at the CRLF2 Locus Implicated in Latin American ALL Health Disparities.
Christopher Steele (Ludmil Alexandrov's lab, UCSD): The imprints of genomic instability across human cancer.
4:30-4:45 pm
Poster and Talk Awards Announcement/Closing remarks
Congratulations to the awardees!
Talk award: Ambrocio Sanchez (Rémi Buisson’s Lab) - Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes.
1st place poster award: Chetan C. Rawal (Chiolo Lab)
High resolution profiling of Double strand break responses in heterochromatin
2nd place poster awards:
Nadejda Butova (Chiolo Lab)
Ulp1: a Clock for Heterochromatin Repair
Metzle Cisneros-Aguirre (Stark Lab)
Defining the role of chromosomal break end synapsis factors in blunt DSB EJ
5-6:30 pm
Dinner
USC PIs Organizing Committee: Irene Chiolo, Matthew Michael, Susan Forsburg, Oscar Aparicio
USC Student/Postdoc Organizing Committee: Chetan Rawal, Chiara Merigliano, Anik Mitra, Nadejda Butova, Jacob Miller, Trevor Reynolds, Yunting Ma, Yunan Wu, Cathy Ma (Website master).
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