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Find below lab publications by date
Find below lab publications by date
2026
2026
EXO1 Facilitates MiDAS and Prevents Genome Instability and Cell Death in Ewing Sarcoma
J Joaquín Olmedo-Pelayo, Laura Lobo-Selma, Daniel Delgado-Bellido, Carmen Jordan-Pérez, Paula Gilabert-Prieto, Marco Pérez, Florian H. Geyer, Martha J. Carreño-Gonzalez, Javier Alonso, Li Zheng, Binghui Shen, View ORCID ProfileThomas G. P. Grünewald, Fernando Gómez-Herreros*, E. de Álava.* *corresponding authors
bioRxiv 2026 June
2025
2025
EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism.
Joaquin Olmedo-Pelayo, Esperanza Granado-Calle, Daniel Delgado-Bellido, Laura Lobo-Selma, Carmen Jordán-Pérez, Ana T. Monteiro-Amaral, Anna C. Ehlers, Shunya Ohmura, Angel M. Carcaboso, Javier Alonso, Isidro Machado, Antonio Llombart-Bosch, Thomas G.P. Grünewald, Fernando Gómez-Herreros*, Enrique de Álava*. *corresponding authors
Oncogene 2025 July
SCAN1 mutant TDP1 blocks the repair of DSB induced by TOP1 activity during gene transcription and promotes genome reorganisations and cell death in quiescent cells
Diana Rubio-Contreras #, Daniel Hidalgo-García #, Carmen Angulo-Jiménez, Esperanza Granado-Calle, Margarita Sabio-Bonilla, Jose F. Ruiz, Fernando Gómez-Herreros # joined first authors
Cell Death and Disease 2025 December
2023
2023
TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription
Diana Rubio Contrera & Fernando Gómez Herreros
Nature Communications. 2023 Nov
Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
Yichao Zhao, Daniel Tabet, Diana Rubio Contreras, Arne Nedergaard Kousholt, Jochen Weile, Henrique Melo, Lisa Hoeg, Atina G. Coté, Zhen-Yuan Lin, Dheva Setiaputra, Jos Jonkers, Anne-Claude Gingras, Fernando Gómez Herreros, Frederick P. Roth, Daniel Durocher
Molecular Cell. 2023 Jul
2020
2020
Canonical Non-Homologous End-Joining Promotes Genome Mutagenesis and Translocations Induced by Transcription-associated DNA Topoisomerase 2 Activity
Olmedo-Pelayo J #, Rubio-Contreras D # , Gómez-Herreros F
Nucleic Acids Research. 2020 Sept
2019
2019
DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II
Gómez-Herreros F
Frontiers in Molecular Biosciences. 2019 Dec
FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress.
Martinez-Macias MI, Moore DA, Green RL, Gomez-Herreros F, Naumann M, Hermann A, Van Damme P, Hafezparast M, Caldecott KW.
Life Sci Alliance. 2019 Feb
2017
2017
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.
Gómez-Herreros F*, Zagnoli-Vieira G, Ntai I, Martínez-Macías MI, Anderson RM, Herrero-Ruíz A, Caldecott KW*. *corresponding authors
Nature Communications. 2017 Aug
Other relevant contributions in the past
Other relevant contributions in the past
Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections.
Maciejewski S, Nguyen JH, Gómez-Herreros F, Cortés-Ledesma F, Caldecott KW, Semler BL.
MBio. 2015 Dec
Link.
TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy SF, de Vries BB, Caldecott KW.
Nature Genetics 2014 May
Link.
PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.
Rulten SL, Rotheray A, Green RL, Grundy GJ, Moore DA, Gómez-Herreros F, Hafezparast M, Caldecott KW.
Nucleic Acids Research 2014 Jan
Link.
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
Gómez-Herreros F, Romero-Granados R, Zeng Z, Alvarez-Quilón A, Quintero C, Ju L, Umans L, Vermeire L, Huylebroeck D, Caldecott KW, Cortés-Ledesma F.
PLoS Genetics 2013 Jun
Link.
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