Journal papers
S. BOTTI, R. KRAUSE and L.F. PAVARINO (2025) In silico modelling of multi-electrode arrays for enhancing cardiac drug testing on hiPSC-CM heterogeneous tissues, Journal of Physiology, DOI: https://doi.org/10.1113/JP287276 (PDF)
S. BOTTI, C. BARTOLUCCI, C. ALTOMARE, M. PACI, R. KRAUSE, L.F. PAVARINO and S. SEVERI (2024) A novel ionic model for matured and paced atrial-like hiPSC-CMs integrating IKur and IKCa currents, Computers in Biology and Medicine, 180, 108899, ISSN 0010-4825, DOI: 10.1016/j.compbiomed.2024.108899 (PDF)
The code of the AL hiPSC-CMs ionic model is public available on the GitHub repository at the following link : https://github.com/bottiso/AL_hiPSC_ionic_model.git
S. BOTTI, M. TORRE (2023) Isogeometric simulation of a derived stem cell engineered ventricle, Advances in Computational Science and Engineering, 1(3), 298-319. DOI: 10.3934/acse.2023013 (PDF)
Preprints
S. BOTTI, C. BARTOLUCCI, C. ALTOMARE, M. PACI, R. KRAUSE, L. F. PAVARINO, and S. SEVERI (2024) A novel ionic model for matured and paced atrial-like hiPSC-CMs integrating IKur and IKCa currents. bioRxiv preprint, DOI: 10.1101/2024.01.12.574782
Conference papers
(**) peer-reviewed
(**) S. BOTTI, C. BARTOLUCCI, R. KRAUSE, L. F. PAVARINO, and S. SEVERI (2023) “An in silico Study of Cardiac hiPSC Electronic Maturation by Dynamic Clamp”. Functional Imaging and Modeling of the Heart. Ed. by O. BERNARD, P. CLARYSSE, N. DUCHATEAU, J. OHAYON, and M. VIALLON. Cham: Springer Nature Switzerland, pp. 175–183. ISBN: 978-3-031-35302-4, DOI: 10.1007/978-3-031-35302-4_18 (PDF)
(**) S. BOTTI, C. BARTOLUCCI, C. ALTOMARE, L. BARILE, R. KRAUSE, S. SEVERI (2023) et al. “Numerical Simulations Indicate IK1 Dynamic Clamp Can Unveil the Phenotype of Cardiomyocytes Derived from Induced Pluripotent Stem Cells”. 2022 Computing in Cardiology (CinC), 171-183. ISSN: 2325-887X, DOI: 10.22489/CinC.2022.101. (PDF)
PhD Thesis
S. BOTTI (2022) Mathematical modeling of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs): from ionic currents to 3D ventricle models, https://hdl.handle.net/11571/1467309 (PDF)