Explore
MedChemBlog
of General Medicinal Chemistry
c/o Magna Græcia University
of Catanzaro
Dear Students of the UMG General Medicinal Chemistry course,
this blog belongs to You!
The MedChemBlog arises from the boundless amount of structural chemical informations available online on accredited and scientifically valid databases (Protein Data Bank, Drug Bank, PubChem and others), but above all from the desire to stimulate the participation of you students and thus, make enjoyable and interactive our current online teaching experience, due to Covid-19.
During 2020/2021 academic year, with the aim of promoting the development of skills in understanding the molecular structures and mechanisms of drug functioning, we placed at the service of the topics covered by the course, the many cues and references you proposed and discussed together during our lessons.
Your insights and cues will then be the ones to design this blog and color our palette with new and different shades .. the chemist's laboratory, besides, is not so far from that of the artist!
Have a good job but mainly, have fun!
Gentili Studenti del corso di Chimica Farmaceutica Generale dell'UMG,
questo blog Vi appartiene!
Il MedChemBlog nasce dalla sconfinata mole di informazioni chimico strutturali disponibili online su database accreditati e scientificamente validi (Protein Data Bank, Drug Bank, PubChem e altri), ma soprattutto dalla volontà di stimolare la partecipazione di Voi discenti e rendere quindi godibile e interattiva la nostra attuale esperienza di didattica online, causa Covid-19.
Durante l' anno accademico 2020/2021, con lo scopo di favorire lo sviluppo delle competenze nella comprensione delle strutture e dei meccanismi molecolari del funzionamento dei farmaci, abbiamo portato a sostegno degli argomenti previsti dal corso, i tanti spunti e riferimenti da Voi proposti e discussi assieme a lezione.
Saranno proprio quest'ultimi, dunque, a disegnare questo blog e a colorare la nostra tavolozza di sfumature nuove e diverse.. il laboratorio del chimico d'altronde, non è poi così distante da quello dell'artista!
Buon lavoro e buon divertimento!!
Prof. Stefano Alcaro
"Food for thought"
by our students
(total number of entries: 38)
1 topic
Brief history of drug discovery and development
Doering and Woodward at Harvard in 1944: synthesis of quinoline (onlinelibrary)
Crystal structure of the mu-opioid receptor bound to a morphinan antagonist – 4DKL
Chloroquine binds in the cofactor binding site of Plasmodium Falciparum lactate dehydrogenase – 1CET
Human Phenylalanine Hydroxylase catalytic domain dimer with bound Adrenaline inhibitor – 3PAH
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital -6X3W
Human Dihydrofolate reductase complexed with NADPH and Trimethoprim – 2W3A
Atorvastatin (Pubchem)
Complex of the catalytic portion of human hmg-coa reductase with atorvastatin -1HWK
Ethinyl estradiol (Pubchem)
Crystal structure of the human DDR1 kinase domain in complex with imatinib -4BKJ
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus diazepam – 6X3X
Modello GABA da CSD (CCDC web site)
Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and Flumazenil, conformation B - 6D6T
Crystal structure of the extracellular domain of human GABA(B) receptor bound to the agonist Baclofen – 4MS4
5 topic
Pharmacokinetics
from Molecular Conceptor learning series
8 topic
Peptidomimetics, isosteres and bioisosteres
Contact us & credits
alcaro@unicz.it - isabella.romeo@unicz.it
giulia.panzarella@studenti.unicz.it
Stefano Alcaro, Prof. of General Medicinal Chemistry and Medicinal and Toxicological Chemistry I
Tel. 0961.3694197
c/o Magna Graecia University of Catanzaro, Viale Europa 88100 Catanzaro, Italy