Sourav joined the laboratory in August 2019 as an EHS I Ph.D. student. He completed his Master of Science in biology from Southeast Missouri State University, Cape Girardeau, MO, in July 2019 and his Ph.D. in July 2023. His research is focused on mechanisms underlying the epigenetic inheritance of bisphenol A-induced non-alcoholic fatty liver disease (NAFLD). He uses molecular, cellular, next-generation sequencing of transcriptome and methylome and bioinformatic approaches to unravel epigenetic and genetic processes associated with the onset and progression of NAFLD in medaka fish liver.

Publications (Google Scholar)

1. Chakraborty, S., Anand, S., Coe, S.T., Reh, B., Bhandari, R.K. (2023). The PCOS–NAFLD Multi-disease phenotype occurred in medaka fish four generations after the removal of bisphenol A exposure. Environmental Science and Technology 57 (34), 12602-12619.

2. Chakraborty, S., Dissanayake, M., *Godwin, J., ‡Wang, X., Bhandari, R.K. (2023). Ancestral BPA exposure caused defects in the liver of medaka for four generations. Science of the Total Environment.856 (1):159067.

3. Vassall, M.; Chakraborty, S.; Feng, Y.; Faheem, M.; Wang, X.; Bhandari, R.K. (2023). Transcriptional Alterations Induced by Delta-9 Tetrahydrocannabinol in the Brain and Gonads of Adult Medaka. Journal of  Xenobiotics. 13, 237-251. https://doi.org/10.3390/jox13030032 

4. Chakraborty S, Anand S, Bhandari RK. (2024). Sex-specific expression of the human NAFLD-NASH transcriptional signatures in the medaka liver with a history of ancestral bisphenol A exposure. bioRxiv. 2024:2024.05.19.594843. 

5. Bhandari, R.K., ‡Chakraborty, S., ‡Faheem, M. (2024). Environmentally induced epigenetic transgenerational inheritance in fish and mammals female reproduction. Encyclopedia of Reproduction. Third Edition, pp 175-179. 

6. Coe, S., Chakraborty, S., Faheem, M., Kupradit, K., Bhandari, R.K. (2024). A second hit by PFOS exposure exacerbated developmental defects in medaka embryos with a history of ancestral BPA exposure. Chemosphere, 362: 142796. 

7. Doldron, M., Chakraborty, S., Anand, S., Faheem, M., Reh, B., Wang, X., Mallik, S., Jia, Z., Bhandari, R. K. (2024). Cellular and transcriptional responses of human bronchial epithelial cells to delta-9-tetrahydrocannabinol  in vitro. International Journal of Molecular Sciences. ijms26115212.

8. Chakraborty, S., Anand, S., Numan, M., Bhandari, R.K. (2025). Ancestral bisphenol A exposure led to nonalcoholic fatty liver disease and sex-specific alterations in proline and bile metabolism pathways in the liver. Environmental Toxicology and Chemistry. Vgae081. 

9. Chakraborty, S., Anand, S., Bhandari, R.K. Medaka liver developed Human NAFLD-NASH transcriptional signatures in response to ancestral bisphenol A exposure.  Under review

10. ‡Chakraborty, S., ‡Anand, S., Wang, X., Bhandari, R.K. Stable transmission of DNA methylation epimutations from germline to the liver and their association with fatty liver disease. Submitted.

11. ‡#Chakraborty, S., **#Coe, S.T., Anand, S., ‡Faheem, M., Wang, X., Bhandari, R.K. PFOS caused fertility defects and disrupted spermatogenic gene networks in the male medaka with a transgenerational history of ancestral BPA exposure. Environmental Research. 122056.

12. Chakraborty, S., Nath, J., Giri, A., Bhandari, R.K. (2025). Epigenetic basis for environmentally induced liver disease. Review (Submitted)

13. *Chakraborty, S., *Reh, B, Anand, S., Feng, Y, Wang, X., Bhandari, R.K. Vitamin C mitigates potassium perchlorate exposure-induced disruption of spermatogenesis in medaka (Submitted). *Equally contributing first authors.

14. Chakraborty, S., Anand, S., Bhandari, R.K. Transcriptional and DNA methylation landscape of the medaka liver (in preparation)

15. Chakraborty, S., Anand, S., Bhandari, R.K. Amelioration of steatosis in the liver by vitamin C treatment involved correction of ancestrally-induced BPA-induced epimutations  and associated transcriptome (in preparation)

Santosh worked as a contract scientist from May 2022 through June 2023 while at the University of North Carolina Greensboro and joined the laboratory at the University of Missouri in May 2024. His research is focused on the integration of epigenetic alterations with the phenotypes induced by environmental stressors. He has extensive experience in sequencing data analysis (single cell RNA, bulk RNA, methylseq, WGBS, and single cell methylome), big data analysis (clinical), computational biology, and artificial intelligence. 

Publications

1. Chakraborty, S., Anand, S., Coe, S.T., Reh, B., Bhandari, R.K. (2023). The PCOS–NAFLD Multi-disease phenotype occurred in medaka fish four generations after the removal of bisphenol A exposure. Environmental Science and Technology 57 (34), 12602-12619.

2. Chakraborty S, Anand S, Bhandari RK. Sex-specific expression of the human NAFLD-NASH transcriptional signatures in the medaka liver with a history of ancestral bisphenol A exposure. bioRxiv. 2024:2024.05.19.594843. 

3. Doldron, M., Chakraborty, S., Anand, S., Faheem, M., Reh, B., Wang, X., Mallik, S., Jia, Z., Bhandari, R. K. (2024). Cellular and transcriptional responses of human bronchial epithelial cells to delta-9-tetrahydrocannabinol  in vitro. International Journal of Molecular Sciences. ijms26115212.

4. Chakraborty, S., Anand, S., Numan, M., Bhandari, R.K. (2025). Ancestral bisphenol A exposure led to nonalcoholic fatty liver disease and sex-specific alterations in proline and bile metabolism pathways in the liver. Environmental Toxicology and Chemistry. Vgae081. 

5. Chakraborty, S., Anand, S., Bhandari, R.K. Medaka liver developed Human NAFLD-NASH transcriptional signatures in response to ancestral bisphenol A exposure.  Under Review

6. #Chakraborty, S., #Anand, S., Wang, X., Bhandari, R.K. Stable transmission of DNA methylation epimutations from germline to the liver and their association with fatty liver disease. Submitted. #equal contribution

7. ‡#Chakraborty, S., **#Coe, S.T., Anand, S., ‡Faheem, M., Wang, X., Bhandari, R.K. PFOS caused fertility defects and disrupted spermatogenic gene networks in the male medaka with a transgenerational history of ancestral BPA exposure. Environmental Research. 122056. #Equal contribution. 

8. *Chakraborty, S., *Reh, B, Anand, S., Feng, Y, Wang, X., Bhandari, R.K. Vitamin C mitigates potassium perchlorate exposure-induced disruption of spermatogenesis in medaka (In preparation). *Equally contributing first authors.

9. Chakraborty, S., Anand, S., Bhandari, R.K. Transcriptional and DNA methylation landscape of the medaka liver (in preparation)

10. Chakraborty, S., Anand, S., Bhandari, R.K. Amelioration of steatosis in the liver by vitamin C treatment involved correction of ancestrally-induced BPA-induced epimutations in the liver (in preparation)