Xianghua Luo, PhD

My methodological research includes: recurrent events, survival analysis, and correlated data analysis.

(The underlined first author was Luo’s student; * indicates that Luo is the corresponding author)

• Luo X*, Sorock GS. (2008). Analysis of recurrent event data under the case-crossover design with applications to elderly falls. Statistics in Medicine, 27:2890-2901. doi: 10.1002/sim.3171

• Luo X*, Wang M-C, Huang C-Y. (2010). A comparison of various rate functions of a recurrent event process in the presence of a terminal event. Statistical Methods in Medical Research, 19(2):167-182. doi: 10.1177/0962280208090220

• Luo X*†, Huang C-Y†. (2011). Analysis of recurrent gap time data using the weighted risk set method and the modified within-cluster resampling method. Statistics in Medicine, 30(4):301-311. †Contributed equally. doi: 10.1002/sim.4074

• Huang C-Y, Luo X, Follmann D. (2011). A model checking method for the proportional hazards model with recurrent gap time data. Biostatistics, 12(3):535–547. doi: 10.1093/biostatistics/kxq071

• Liao W, Luo X*, Le C, Chu H, Epstein LH, Yu J, Ahluwalis JS, Thomas J. (2013). Analysis of cigarette purchase task instrument data with a left-censored mixed effects model. Experimental and Clinical Psychopharmacology, 21(2):124–132. doi: 10.1037/a0031610

• Luo X*, Huang C-Y, Wang L. (2013). Quantile regression for recurrent gap time data. Biometrics, 69(2):375-385. doi: 10.1111/biom.12010

• Lee CH, Luo X*, Huang C-Y, DeFor T, Brunstein CG, Weisdorf DJ. (2016). Nonparametric estimation of joint distribution of time from umbilical cord blood transplantation to first infection and gap times between recurrent infections. Biometrics, 72(2):535-545. doi: 10.1111/biom.12439

• Zhao T, Luo X*, Chu H, Le CT, Epstein LH, Thomas JL. (2016). A two-part mixed effects model for cigarette purchase task data. Journal of the Experimental Analysis of Behavior, 106(3):242-253. doi: 10.1002/jeab.228

• Ho YY, Vo TN, Chu H, Luo X, Le CT. (2018). A Bayesian hierarchical model for demand curve analysis. Statistical Methods in Medical Research, 27(7):2038-2049. doi: 10.1177/0962280216673675

• Lee CH, Huang C-Y, Xu G, Luo X. (2018). Semiparametric regression model for alternating recurrent event data. Statistics in Medicine, 37(6):996-1008. doi: 10.1002/sim.7563

• Lyu T, Luo X*, Xu G, Huang C-Y. (2018). Induced smoothing for rank-based regression with recurrent gap time data. Statistics in Medicine, 37(7):1086-1100. doi: 10.1002/sim.7564

• Zhang Y, Luo X*, Le CT, Ahluwalis JS, Thomas J. (2018). Analysis of self-report and biochemically verified tobacco abstinence outcomes with missing data: a sensitivity analysis using two-stage imputation. BMC Medical Research Methodology, 2018,18:170. doi: 10.1186/s12874-018-0635-2

• Lee CH, Huang C-Y, DeFor T, Brunstein CG, Weisdorf DJ, Luo X. (2019). Semiparametric regression model for recurrent bacterial infections after hematopoietic stem cell transplantation. Statistica Sinica, 29(3):1489-1509. doi: 10.5705/ss.202017.0397

• Koopmeiners KS, Vock DM, Boatman JA, Carroll D, Colby SM, Donny EC, Hatsukami DK, Luo X, Tidey JW. (2019). The importance of estimating causal effects for evaluating a nicotine standard for cigarettes. Nicotine & Tobacco Research, 2019 Dec 23; 21(Suppl 1):S22-S25. doi: 10.1093/ntr/ntz119

• Cao W, Hecht SS, Murphy SE, Chu H, Benowitz NL, Donny EC, Hatsukami DK,  Luo X*. (2020). Analysis of multiple biomarkers using structural equation modeling. Tobacco Regulatory Science, 6(4):266-278. doi: 10.18001/trs.6.4.4

• Lyu T, Luo X, Huang C-Y, Sun Y. (2021). Additive rates model for recurrent event data with intermittently observed time-dependent covariates. Statistical Methods in Medical Research, 30(10):2239–2255. doi: 10.6339/21-JDS1027

• Shi L, Hatsukami D, Benowitz N, Koopmeiners JS, Le CT, Donny EC, Luo X*. (2021). Statistical methods for analyzing area under the curve of longitudinally measured biomarkers with missing data. Pharmaceutical Statistics, 20(6):1249-1264. doi: 10.1002/pst.2146

• Lyu T, Luo X, Sun Y. (2021). Additive-multiplicative rates model for recurrent event data with intermittently observed time-dependent covariates. Journal of Data Science, 19(4):615-633. doi: 10.6339/21-JDS1027

• Castro-Pearson S, Le C, Luo X. (2022). Two-sample survival probability curves: A graphical approach for the analysis of time to event data in clinical trials. Contemporary Clinical Trials, 115:106707. doi: 10.1016/j.cct.2022.106707

• Castro-Pearson S, Sur A, Lee CH, Huang C-Y, Luo X* (2022). BivRec: An R package for the nonparametric and semiparametric analysis of bivariate alternating recurrent events. BMC Medical Research Methodology, 22:92. doi: 10.1186/s12874-022-01558-0

• Zhang S, Chu H, Bickel WK, Le CT, Smith TT, Thomas JL, Donny EC, Hatsukami DK, Luo X*. (2022). A Bayesian hierarchical model for individual participant data meta-analysis of demand curves. Statistics in Medicine, 41(12):2276-2290. doi: 10.1002/sim.9354

• Eaton A, Sun Y, Neaton J, Luo X. (2022). Non-parametric estimation in an illness-death model with component-wise censoring. Biometrics, 78(3):1168-1180. doi: 10.1111/biom.13482

• Wolf JM, Vock DM, Luo X, Hatsukami DK, McClernon FJ, Koopmeiners JS. (2024). Leveraging information from secondary endpoints to enhance dynamic borrowing across subpopulations. Biometrics, 2024 Oct 3;80(4):ujae118. doi: 10.1093/biomtc/ujae118

My collaborative research are mainly tobacco research and BMT. 

 Tobacco Research (Selected Recent Publications):

• Hatsukami DK, Luo X, Jensen JA, et al. (2018). Effect of immediate vs. gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure: a randomized clinical trial. JAMA, 320(9):880-891.

• Hatsukami DK, Luo X, Heskin AK, et al. (2019). Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects. Addiction, 114(10):1824-1833.

• Luo X, Carmella SG, Chen M, Jensen JA, Wilkens LR, Marchand LL, Hatsukami DK, Murphy SE, Hecht SS. (2020). Urinary cyanoethyl mercapturic acid as a reliable indicator of combusted tobacco products versus e-cigarettes or smokeless tobacco. Nicotine & Tobacco Research, 22(10):1744-1747.

• Luo K, Luo X, Cao W, Hochalter JB, Paiano V, Fujioka N, Wang J, Sipe CJ, Carmella SG, Murphy SE, Hatsukami D, Jensen J,  Lam S, Golin AP, Bergstrom L, Midthun D, Hecht SS. (2021). Cigarette smoking enhances the metabolic activation of the polycyclic aromatic hydrocarbon phenanthrene in humans. Carcinogenesis, 42(4):570-577.

• Carroll DM, Tessier KM, Cummings KM, O'Connor RJ, Reisinger S, Shields PG, Stepanov I, Luo X, Hatsukami D, Rees VM. (2023). Risk perceptions and continued smoking as a function of cigarette filter ventilation level among U.S. youth and young adults who smoke. Tobacco Control, 32(4):473-479.

• Hatsukami DK, Jensen JA, Carroll DM, Luo X, Strayer LG, Cao Q, Hecht SS, Murphy SE, Carmella SG, Delinger-Apte RL, Colby S, Strasser AA, McClernon FJ, Tidey J, Benowitz NL, Donny EC. (2024). Reduced nicotine in cigarettes in a marketplace with alternative nicotine systems: randomized clinical trial. Lancet Reg Health Am, 35:100796.

• Smith TT, Luo X, Benowitz NL, Colby SM, McClernon FJ, Strasser AA, Tidey JW, Donny EC, Hatsukami DK. The impact of nicotine reduction on cigarette reinforcement value within a marketplace containing alternative nicotine delivery products: A secondary analysis of a multi-site trial. Nicotine & Tobacco Research, 2025 Jul 4:ntaf138. Online ahead of print.

 BMT Research (Selected Recent Publications):

• Rashidi A, Ebadi M, Rehman TU, Elhusseini H, Kazadi D, Halaweish H, Khan M, Hoeschen A, Cao Q, Luo X, Holtan SG, Weisdorf DJ, Khoruts A, Staley C. (2023). Randomized double-blind phase II trial of fecal microbiota transplantation versus placebo in allogeneic hematopoietic Cell transplantation and acute myeloid leukemia. Journal of Clinical Oncology, 41(34):5306-5319.

• Rashidi A, Ebadi M, Ur Rehman T, Elhusseini H, Kazadi D,  Halaweish H, Khan MH, Hoeschen A, Cao Q, Luo X, Kabage AJ, Lopez S, Holtan SG, Weisdorf DJ, Khoruts A, Staley C. (2023). Potential of fecal microbiota transplantation to prevent acute graft-versus-host disease. Clinical Cancer Research, 29(23):4920-4929.

• Rashidi A, Ebadi M, Ur Rehman T, Elhusseini H, Kazadi D, Halaweish H, Khan MH, Hoeschen A, Cao Q, Luo X, Kabage AJ, Lopez S, Holtan SG, Weisdorf DJ, Liu C,  Ishii S, Khoruts A, Staley C. (2024). Long- and short-term effects of fecal microbiota transplantation on antibiotic resistance genes: results from a randomized placebo-controlled trial. Gut Microbes, 16(1):2327442.

• Rashidi A, Ebadi M, Rehman TU, Elhusseini H, Kazadi D, Halaweish H, Khan MH, Hoeschen A, Cao Q, Luo X, Kabage AJ, Lopez S, Ramamoorthy S, Holtan SG, Weisdorf DJ, Khoruts A, Staley C. (2024). Multi-omics analysis of a fecal microbiota transplantation trial identifies novel aspects of acute graft-versus-host disease pathogenesis. Cancer Res Commun, 4(6):1454-1466.

• Kennedy PR, Arvindam1 US, Phung SK, Ettestad B, Feng X, Li Y, Kile QM, Hinderlie P, Khaw M, Huang R-S, Kaufman M, Puchalska P, Russell A,  Butler J, Abbott L, McClure P, Luo X, Lu QT, Blazar BR,  Crawford PA, Lim J, Miller JS, Felices M. (2024). Metabolic programs drive function of therapeutic NK cells in hypoxic tumor environments. Science Advances, 10(44):eadn1849. 

• Phung SK, Zorko N, Soignier Y, Waller R, Shackelford M, Walker JT, Nelson TD, Selleck C, Bendzick LE, Kotz LE, Kile QM, Bozicevich AJ, Miller SE, Khaw M, Shetty M, Hinderlie P, Ehrhardt M, Li Y, Luo X, Dehm SM, Antonarakis ES, Kennedy PR, Miller JS, Felices M. (2025).  A PSMA-targeted Tri-specific Killer Engager enhances NK cell cytotoxicity against prostate cancer. Cancer Immunology Research, 13(2):258-272.

• Drozdov D, Luo X, Marsh RA, Abraham RS, Ebens CL. (2025). Relevance of recent thymic emigrants following allogeneic hematopoietic cell transplantation for pediatric patients with inborn errors of immunity. Transplantation and Cellular Therapy, 31(4):265.e1-265.e12.

Presentations

 Selected Recent Presentations:

• Statistical methods for behavioral economics data in tobacco research (slides).

• Two-sample survival probability curves: A graphical approach for the analysis of time-to-event data in clinical trials (slides, recording).

 Selected Recent Student Presentations:

• Sonnenberger M, Luo X, Murray T. Bayesian win probability for implementing the estimand framework in clinical trials with a time-to-event outcome. ENAR, Baltimore, MD, March 10-13, 2024 (co-advised by Murray [primary] and Luo).

• Zhang C, Chu H, Paudel N, Carroll DM, Stepanov I, Yershova K, Koopmeiners JS, Donny EC, Hatsukami DK, Luo X. A Bayesian measurement error model for the effect of cigarette filter ventilation on biomarker exposures of smokers. ENAR, Baltimore, MD, March 10-13, 2024, poster (co-advised by Luo [primary] and Chu).

• Lu H, Luo X, Eaton A. Nonparametric estimation of event-free survival in a prevalent cohort study with intermittently assessed nonfatal events. IBC, Atlanta, GA, December 8-13, 2024 (co-advised by Eaton [primary] and Luo).