Turesky Lab Publications
2023
Konorev D; Bellamri M;Wu CF; Wu MT; Turesky RJ. High-Field Asymmetric Waveform Ion Mobility Spectrometry Analysis of Carcinogenic Aromatic Amines in Tobacco Smoke with an Orbitrap Tribrid Mass Spectrometer. Chem Res Toxicol. 2023 Aug 21;36(8):1419-1426. Link.
Bellamri M; Brandt K; Cammerrer K; Syeda T; Turesky RJ; Cannon JR. Nuclear DNA and Mitochondrial Damage of the Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Human Neuroblastoma Cells. Chem Res Toxicol. 2023 Aug 21;36(8):1361-1373. doi: 10.1021/acs.chemrestox.3c00109. Link
Bellamri M; Terrell JT; Brandt K; Gruppi F; Turesky RJ; Rizzo CJ. Anthracyclines React with Apurinic/Apyrimidinic Sites in DNA. ACS Chem Biol. 2023 Jun 16;18(6):1315-1323. Link.
Jaruga P; Tomar R; Kant M: Vartanian V; Sexton B; Rizzo CJ; Turesky RJ; Stone MP; Lloyd RS; Dizdaroglu M. Synthesis and Characterization of 15N5-Labeled Aflatoxin B1-Formamidopyrimidines and Aflatoxin B1-N7-Guanine from a Partial Double-Stranded Oligodeoxynucleotide as Internal Standards for Mass Spectrometric Measurements. ACS Omega. 2023. Apr 11;8(16):14841-14854. doi: 10.1021/acsomega.3c01328. eCollection 2023 Apr 25. Link.
2022
Guo, J.; Koopmeiners, J. S.; Walmsley, S. J.; Villalta, P. W.; Yao, L.; Murugan, P.; Tejpaul, R.; Weight, C. J.; Turesky, R. J. The Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Hair Dosimeter, DNA Adductomics Discovery, and Associations with Prostate Cancer Pathology Biomarkers. Chem. Res. Toxicol. 2022 May 16;35(5):703-730. Link
Bellamri, M.; Walmsley, S. J.; Brown, C.; Brandt, K.; Konorev, D.; Day, A.; Wu, C. F.; Wu, M. T.; Turesky, R. J. DNA Damage and Oxidative Stress of Tobacco Smoke Condensate in Human Bladder Epithelial Cells. Chem. Res. Toxicol. 2022 Jul 25. doi: 10.1021/acs.chemrestox.2c00153 . 2020. Link.
Konorev, D.; Yao, L.: Turesky, R. J. Multi-DNA Adduct and Abasic Site Quantitation in vivo by Nano-Liquid Chromatography/High-Resolution Orbitrap Tandem Mass Spectrometry: Methodology for Biomonitoring Colorectal DNA Damage. Chem. Res. Toxicol. 2022 Sep 19;35(9):1519-1532. doi: 10.1021/acs.chemrestox.2c00177. Epub 2022 Sep 6. Link.
2021
Hölzl-Armstrong, L.; Moody, S.; Kucab, J. E.; Zwart, E. P.; Bellamri, M.; Luijten, M.; Turesky, R. J.; Stratton, M. R.; Arlt, V. M.; Phillips, D. H. Mutagenicity of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in human TP53 knock-in (Hupki) mouse embryo fibroblasts. Food Chem Toxicol. 2021 Jan;147:111855. Link
Chen, C. H.; Grollman, A. P.; Huang, C. Y.; Shun, C. T.; Sidorenko, V. S.; Hashimoto, K.; Moriya, M.; Turesky, R. J.; Yun, B-H.; Tsai, K.; Wu. S.; Chuang, P. Y.; Tang, C. H.; Yang, W. H.; Tzai, T. S.; Tsai, Y. S.; Dickman, K. G.; Pu, Y. S. Additive Effects of Arsenic and Aristolochic Acid in Chemical Carcinogenesis of Upper Urinary Tract Urothelium. Cancer Epidemiol Biomarkers Prev. 2021 Feb;30(2):317-325. Link
Walmsley, S. J.; Guo, J.; Murugan, P.; Weight, C. J.; Wang, J.; Villalta, P. W.: Turesky, R. J. Comprehensive Analysis of DNA Adducts Using Data-Independent wSIM/MS2 Acquisition and wSIM-City. Anal Chem. 2021 Apr 27;93(16):6491-6500. Link
Bellamri, M.; Walmsley, S.J.; Turesky, R.J. Metabolism and Biomarkers of Heterocyclic Aromatic Amines in Humans. Genes Env., 2021 July 16;43(21):29. Link
Lin, P. C.; Peng, C. Y.; Pan, C.H.; Lee, J. Y.; Hsieh, T. J.; Chuang, Y.S.; Turesky, R. J.; Wu, C. F.; Wu, M. T. Risk of two common glandular cell-type cancers (breast and colorectal cancers) in Chinese occupational chefs: a nationwide ecological study in Taiwan. Int. Arch. Occu.p Environ Health. 2021 Aug;94(6):1363-1373. Link
Okello, S.; Byaruhanga, E.; Akello, S. J.; Dwomoh, E.; Opio, C. K.; Corey, K. E.; Ocama, P.; Guo, J.; Muyindike, W. R.; Turesky, R. J.; Christiani, D. C. Dietary Heterocyclic Amine Intake and Risk of Esophageal Squamous Cell Carcinoma in Rural Uganda. Int. J. Cancer Clin. Res. 2021;8(3):152. Link
Bellamri, M.; Brandt, K.; Brown, C. V.; Wu, M. T.; Turesky, R. J. Cytotoxicity and genotoxicity of the carcinogen aristolochic acid I (AA-I) in human bladder RT4 cells. Arch. Toxicol. 2021 Jun;95(6):2189-2199 . Link
2020
Lawana, V.; Um, S. Y.; Rochet, J. C.; Turesky, R. J.; Shannahan, J. H.; Cannon, J. R. Neuromelanin Modulates Heterocyclic Aromatic Amine-Induced Dopaminergic Neurotoxicity. Toxicol Sci. 2020 Jan 1;173(1):171-188. Link
Peterson, L. A.; Balbo, S.; Fujioka, N.; Hatsukami, D. K.; Hecht, S. S.; Murphy, S. E.; Stepanov, I.; Tretyakova, N.; Turesky, R. J.; Villalta, P. W. Applying Tobacco, Environmental and Dietary-related Biomarkers to Understand Cancer Etiology and Evaluate Prevention Strategies. Cancer Epidemiol Biomarkers Prev. 2020. Link.
Guo, J.; Turesky, R. J.; Tarifa, A.; DeCaprio, A. P.; Cooke, M. S.; Walmsley, S. J.; Villalta, P. W. Development of a DNA Adductome Mass Spectral Database. Chem Res Toxicol, 2020, Link.
Chen, H.; Cui, Z.; Hejazi, L.; Yao, L.; Walmsley, S. J.; Rizzo, C. J.; Turesky, R. J. Kinetics of DNA Adducts and Abasic Site Formation in Tissues of Mice Treated with a Nitrogen Mustard. Chem Res Toxicol, 2020. Link.
2019
Bellamri, M.; Turesky, R. J. Dietary Carcinogens and DNA Adducts in Prostate Cancer. Adv Exp Med Biol, 2019, 1210, 29-55. Link.
Walmsley, S. J.; Guo, J.; Wang, J.; Villalta, P. W.; Turesky, R. J. Methods and Challenges for Computational Data Analysis for DNA Adductomics. Chem Res Toxicol, 2019, 11, 2156-2168. Link.
Chen, H.; Krishnamachari, S.; Guo, J.; Yao, L.; Murugan, P.; Weight, C. J.; Turesky, R. J. Quantitation of Lipid Peroxidation Product DNA Adducts in Human Prostate by Tandem Mass Spectrometry: A Method that Mitigates Artifacts. Chem. Res. Toxicol, 2019. 32, 9, 1850-1862 . Link.
Bellamri, M.; Yao, L.; Bonala, R.; Johnson, F.; Von Weymarn, L.B.; Turesky, R. J. Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AαC) in human bladder RT4 cells. Arch Toxicol, 2019. 7, 1893–1902. Link
Guo, J.; Turesky, R. J. Emerging Technologies in Mass Spectrometry-Based DNA Adductomics. High-Throughput 2019, 8, 13. Link
Chen, H.; Yao, L.; Brown, C.; Rizzo, C. J.; Turesky, R. J. Quantitation of Apurinic/Apyrimidinic Sites in Isolated DNA and in Mammalian Tissue with a Reduced Level of Artifacts. Anal. Chem. 2019, 91, 11, 7403-7410. Link
2018
Guo, J.; Villalta, P.W.; Weight, C. J.; Murugan, P.; Bonala, R.; Johnson, F. Rosenquist, T.; Turesky, R. J. Targeted and Untargeted Detection of DNA Adducts of Aromatic Amine Carcinogens in Human Bladder by Ultra Performance Liquid Chromatography-High Resolution Mass Spectrometry. Chem. Res. Toxicol. 2018, 31, 1382–1397. Link
Bellamri, M.; Wang, Y.; Yonemori, K.; White, K. K.; Wilkens, L. R.; Le Marchand, L.; Turesky, R. J. Biomonitoring an Albumin Adduct of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]pyridine in Humans. Carcinogensis. 2018. 39, 1455–1462. Link.
Yun, B. H.; Bellamri, M.; Rosenquist, T. A.; Turesky, R. J. A Method for Biomonitoring of DNA Adducts in Exfoliated Urinary Cells by Mass Spectrometry. Anal. Chem. 2018. 16, 9943-9950. Link.
Guo, J.; Villalta, P. W.; Turesky, R. J. DNA Adductomic Analysis by Data-Independent Mass Spectrometry . LCGC Current Trends in Mass Spectrometry. 2018. 37, 6-16. Link.
Yun, B. H.; Guo, J.; Turesky, R. J. Formalin-Fixed Paraffin-Embedded Tissues—An Untapped Biospecimen for Biomonitoring DNA Adducts by Mass Spectrometry. Toxics. 2018. 6(2), 30. Link.
Yun, B. H.; Guo, J.; Bellamri, M.; Turesky, R. J. DNA Adducts: formation, biological effects, and new biospecimens for mass spectrometric measurements in humans. Mass Spectrom. Rev. 2018, 1-22. Link.
Bellamri, M.; Xiao, S.; Murugan, P.; Weight, C. J.; Turesky, R. J. Metabolic activation of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in human prostate. Toxicol. Sci. 2018, 163(2), 543-556. PubMed.
2017
Yun, B. H.; Xiao, X.; Yao, L.; Krishnamachari, S.; Rosenquist, T. A.; Dickman, K. G.; Grollman, A. P.; Murugan, P.; Weight, C. J.; Turesky, R. T. A Rapid Throughput Method to Extract DNA from Formalin-Fixed Paraffin-Embedded Tissues for Biomonitoring Carcinogenic DNA Adducts in Humans. Chem. Res. Toxicol. 2017. 30 (12), 2130-2139. PubMed.
Guo, J.; Villalta, P. W.; Turesky, R. J. A Data-Independent Mass Spectrometry Approach for Screening and Identification of DNA Adducts. Anal. Chem. 2017, 89 (21), 11728–11736. PubMed.
Bellamri, M.; Le Hegarat, L.; Turesky, R. J.; Langouet, S., Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AalphaC) in Primary Human Hepatocytes. Chem. Res. Toxicol. 2017, 30 (2), 657-668. PubMed.
Cai, T.; Bellamri, M.; Ming, X.; Koh, W. P.; Yu, M. C.; Turesky, R. J., Quantification of Hemoglobin and White Blood Cell DNA Adducts of the Tobacco Carcinogens 2-Amino-9H-pyrido[2,3-b]indole and 4-Aminobiphenyl Formed in Humans by Nanoflow Liquid Chromatography/Ion Trap Multistage Mass Spectrometry. Chem. Res. Toxicol. 2017, 30 (6), 1333-1343. PubMed.
Sabbioni, G.; Turesky, R. J., Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future. Chem. Res. Toxicol. 2017, 30 (1), 332-366. PubMed.
Wang, Y.; Villalta, P. W.; Peng, L.; Dingley, K.; Malfatti, M. A.; Turteltaub, K. W.; Turesky, R. J., Mass Spectrometric Characterization of an Acid-Labile Adduct Formed with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Albumin in Humans. Chem. Res. Toxicol. 2017, 30 (2), 705-714. PubMed.
2016
Xiao, S.; Guo, J.; Yun, B. H.; Villalta, P. W.; Murugan, P.; Weight, C. J.; Turesky, R. J. Biomonitoring DNA adducts of Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Human Prostate by Nano Liquid Chromatography-High Resolution Tandem Mass Spectrometry. Anal. Chem. 2016, 88, 12508-12515. PubMed.
Guo, J.; Turesky, R. J. Human Biomonitoring of DNA Adducts by Ion Trap Multistage Mass Spectrometry. Curr. Protoc. Nucleic Acid Chem. 2016, 66, 7.24.1-7.24.25. PubMed.
Guo, J.; Yun, B.; Upadhyaya, P.; Yao, L.; Krishnamachari, S.; Rosenquist, T. A.; Grollman, A. P.; Turesky, R. J. Multi-Class Carcinogenic DNA Adduct Quantification in Formalin-Fixed Paraffin-Embedded Tissues by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry. Anal. Chem. 2016, 88, 4780-4787. PubMed.
Kim, S.; Guo, J.; O'Sullivan, G.; Gallaher, D. D.; Turesky, R. J. Comparative DNA Adduct Formation and Induction of Colonic Aberrant Crypt Foci in Mice Exposed to 2-Amino-9H-pyrido[2,3-b]indole, 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline and Azoxymethane. Environ. Mol. Mutagen. 2016, 57, 125-136. PubMed.
Cai, T.; Yao, L.; Turesky, R. J., Bioactivation of Heterocyclic Aromatic Amines by UDP Glucuronosyltransferases. Chem. Res. Toxicol. 2016, 29 (5), 879-91. PubMed.
Hoang, M. L.; Chen, C. H.; Chen, P. C.; Roberts, N. J.; Dickman, K. G.; Yun, B. H.; Turesky, R. J.; Pu, Y. S.; Vogelstein, B.; Papadopoulos, N.; Grollman, A. P.; Kinzler, K. W.; Rosenquist, T. A., Aristolochic Acid in the Etiology of Renal Cell Carcinoma. Cancer Epidemiol. Biomarkers Prev. 2016, 25 (12), 1600-1608 . PubMed.
Bellamri, M.; Le Hegarat, L.; Vernhet, L.; Baffet, G.; Turesky, R. J.; Langouet, S., Human T lymphocytes bioactivate heterocyclic aromatic amines by forming DNA adducts. Environ. Mol. Mutagen. 2016, 57 (9), 656-667. PubMed.
Isin, E. M.; Turesky, R. J., Introduction: Mass Spectrometry and Emerging Technologies for Biomarker Discovery in the Assessment of Human Health and Disease. Chem. Res. Toxicol. 2016, 29 (12), 1901-1902. PubMed.
Le Marchand, L.; Yonemori, K.; White, K. K.; Franke, A. A.; Wilkens, L. R.; Turesky, R. J., Dose validation of PhIP hair level as a biomarker of heterocyclic aromatic amines exposure: a feeding study. Carcinogenesis 2016, 37 (7), 685-691. PubMed.
Pathak, K. V.; Chiu, T. L.; Amin, E. A.; Turesky, R. J., Methemoglobin Formation and Characterization of Hemoglobin Adducts of Carcinogenic Aromatic Amines and Heterocyclic Aromatic Amines. Chem. Res. Toxicol. 2016, 29 (3), 255-69. PubMed.
Sheng, J.; Wang, Y.; Turesky, R. J.; Kluetzman, K.; Zhang, Q. Y.; Ding, X., Novel Transgenic Mouse Model for Studying Human Serum Albumin as a Biomarker of Carcinogenic Exposure. Chem. Res. Toxicol. 2016, 29 (5), 797-809. PubMed.
Turesky, R. J.; Yun, B. H.; Brennan, P.; Mates, D.; Jinga, V.; Harnden, P.; Banks, R. E.; Blanche, H.; Bihoreau, M. T.; Chopard, P.; Letourneau, L.; Lathrop, G. M.; Scelo, G., Aristolochic acid exposure in Romania and implications for renal cell carcinoma. Br. J. Cancer. 2016, 114 (1), 76-80. PubMed.
2015
Guo, J.; Yonemori, K; Le Marchand, L.; Turesky, R. J. A Method to Biomonitor the Cooked Meat Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Dyed Hair by Ultra Performance Liquid Chromatography-Orbitrap High Resolution Multistage Mass Spectrometry. Anal. Chem. 2015, 87, 5872-5877. PubMed
Gruppi, F.; Hejazi, L.; Christov, P. P.; Krishnamachari, S.; Turesky, R. J.; Rizzo, C. J., Characterization of nitrogen mustard formamidopyrimidine adduct formation of bis(2-chloroethyl)ethylamine with calf thymus DNA and a human mammary cancer cell line. Chem. Res. Toxicol. 2015, 28 (9), 1850-60. PubMed.
Konorev, D.; Koopmeiners, J. S.; Tang, Y.; Franck Thompson, E. A.; Jensen, J. A.; Hatsukami, D. K.; Turesky, R. J., Measurement of the Heterocyclic Amines 2-Amino-9H-pyrido[2,3-b]indole and 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Urine: Effects of Cigarette Smoking. Chem. Res. Toxicol. 2015, 28 (12), 2390-9. PubMed.
Monien, B. H.; Schumacher, F.; Herrmann, K.; Glatt, H.; Turesky, R. J.; Chesne, C., Simultaneous detection of multiple DNA adducts in human lung samples by isotope-dilution UPLC-MS/MS. Anal. Chem. 2015, 87 (1), 641-8. PubMed.
Pathak, K. V.; Bellamri, M.; Wang, Y.; Langouet, S.; Turesky, R. J., 2-Amino-9H-pyrido[2,3-b]indole (AalphaC) Adducts and Thiol Oxidation of Serum Albumin as Potential Biomarkers of Tobacco Smoke. J. Biol. Chem. 2015, 290 (26), 16304-18. PubMed.
Turesky, R. J.; Konorev, D.; Fan, X.; Tang, Y.; Yao, L.; Ding, X.; Xie, F.; Zhu, Y.; Zhang, Q. Y., Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-pyrido[2,3-b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice. Chem. Res. Toxicol. 2015, 28 (12), 2400-10. PubMed.
Turesky, R. J.; White, K. K.; Wilkens, L. R.; Le Marchand, L., Caffeine Cytochrome P450 1A2 Metabolic Phenotype Does Not Predict the Metabolism of Heterocyclic Aromatic Amines in Humans. Chem. Res. Toxicol. 2015, 28 (8), 1603-15. PubMed.
Wang, Y.; Peng, L.; Bellamri, M.; Langouet, S.; Turesky, R. J., Mass Spectrometric Characterization of Human Serum Albumin Adducts Formed with N-Oxidized Metabolites of 2-Amino-1-methylphenylimidazo[4,5-b]pyridine in Human Plasma and Hepatocytes. Chem. Res. Toxicol. 2015, 28 (5), 1045-59. PubMed.
Yun, B. H.; Sidorenko, V. S.; Rosenquist, T. A.; Dickman, K. G.; Grollman, A. P.; Turesky, R. J., New Approaches for Biomonitoring Exposure to the Human Carcinogen Aristolochic Acid. Toxicol. Res. 2015, 4 (4), 763-776. PubMed.
2014
Balbo, S.; Turesky, R. J.; Villalta, P. W., DNA adductomics. Chem. Res. Toxicol. 2014, 27 (3), 356-66. PubMed.
Peng, L.; Turesky, R. J., Optimizing proteolytic digestion conditions for the analysis of serum albumin adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, a potential human carcinogen formed in cooked meat. J. Proteom. 2014, 103, 267-78. PubMed.
Yun, B. H.; Yao, L.; Jelakovic, B.; Nikolic, J.; Dickman, K. G.; Grollman, A. P.; Rosenquist, T. A.; Turesky, R. J., Formalin-fixed paraffin-embedded tissue as a source for quantitation of carcinogen DNA adducts: aristolochic acid as a prototype carcinogen. Carcinogenesis 2014, 35 (9), 2055-61. PubMed.
2013
Hoang, M. L.; Chen, C. H.; Sidorenko, V. S.; He, J.; Dickman, K. G.; Yun, B. H.; Moriya, M.; Niknafs, N.; Douville, C.; Karchin, R.; Turesky, R. J.; Pu, Y. S.; Vogelstein, B.; Papadopoulos, N.; Grollman, A. P.; Kinzler, K. W.; Rosenquist, T. A., Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing. Sci. Transl. Med. 2013, 5 (197). PubMed.PubMed.
Nauwelaërs, G.; Bellamri, M.; Fessard, V.; Turesky, R. J.; Langouët, S. DNA Adducts of the Tobacco Carcinogens 2-Amino-9H-pyrido[2,3-B]indole and 4-Aminobiphenyl Are Formed at Environmental Exposure Levels and Persist in Human Hepatocytes. Chem. Res. Toxicol. 2013, 26 (9), 1367–1377. PubMed.
Peng, L.; Turesky, R. J. Capturing Labile Sulfenamide and Sulfinamide Serum Albumin Adducts of Carcinogenic Arylamines by Chemical Oxidation. Anal. Chem. 2013, 85 (2), 1065–1072. PubMed.
Tang, Y. J.; Kassie, F.; Qian, X. M.; Ansha, B.; Turesky, R. J., DNA Adduct Formation of 2-Amino-9H-pyrido[2,3-b]indole and 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline in Mouse Liver and Extrahepatic Tissues During a Subchronic Feeding Study. Toxicol. Sci. 2013, 133 (2), 248-258. PubMed.
Turesky, R. J.; Liu, L.; Gu, D.; Yonemori, K. M.; White, K. K.; Wilkens, L. R.; Le Marchand, L. Biomonitoring the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-phenylimidazo[4,5-B]pyridine in Hair: Impact of Exposure, Hair Pigmentation, and Cytochrome P450 1A2 Phenotype. Cancer Epidemiol. Biomarkers Prev. 2013, 22 (3), 356–364. PubMed.
Yun, B. H.; Rosenquist, T. A.; Nikolić, J.; Dragičević, D.; Tomić, K.; Jelaković, B.; Dickman, K. G.; Grollman, A. P.; Turesky, R. J. Human Formalin-Fixed Paraffin-Embedded Tissues: An Untapped Specimen for Biomonitoring of Carcinogen DNA Adducts by Mass Spectrometry. Anal. Chem. 2013, 85 (9), 4251–4258. PubMed.
Selected Publications Before 2013
Peng, L.; Turesky, R. J. Capturing Labile Sulfenamide and Sulfinamide Serum Albumin Adducts of Carcinogenic Arylamines by Chemical Oxidation. Anal. Chem. 2013, 85 (2), 1065–1072. PubMed.
Yun, B. H.; Rosenquist, T. A.; Nikolić, J.; Dragičević, D.; Tomić, K.; Jelaković, B.; Dickman, K. G.; Grollman, A. P.; Turesky, R. J. Human Formalin-Fixed Paraffin-Embedded Tissues: An Untapped Specimen for Biomonitoring of Carcinogen DNA Adducts by Mass Spectrometry. Anal. Chem. 2013, 85 (9), 4251–4258. PubMed.
Yun, B. H.; Rosenquist, T. A.; Sidorenko, V.; Iden, C. R.; Chen, C.-H.; Pu, Y.-S.; Bonala, R.; Johnson, F.; Dickman, K. G.; Grollman, A. P.; et al. Biomonitoring of Aristolactam-DNA Adducts in Human Tissues Using Ultra-Performance Liquid Chromatography/Ion-Trap Mass Spectrometry. Chem. Res. Toxicol. 2012, 25 (5), 1119–1131. PubMed.
Tang, Y.; LeMaster, D. M.; Nauwelaërs, G.; Gu, D.; Langouët, S.; Turesky, R. J. UDP-Glucuronosyltransferase-Mediated Metabolic Activation of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-B]indole. J. Biol. Chem. 2012, 287 (18), 14960–14972. PubMed.
Peng, L.; Dasari, S.; Tabb, D. L.; Turesky, R. J. Mapping Serum Albumin Adducts of the Food-Borne Carcinogen 2-Amino-1-Methyl-6-phenylimidazo[4,5-B]pyridine by Data-Dependent Tandem Mass Spectrometry. Chem. Res. Toxicol. 2012, 25 (10), 2179–2193. PubMed.
Gu, D.; Turesky, R. J.; Tao, Y.; Langouët, S. A.; Nauwelaërs, G. C.; Yuan, J.-M.; Yee, D.; Yu, M. C. DNA Adducts of 2-Amino-1-Methyl-6-phenylimidazo[4,5-B]pyridine and 4-Aminobiphenyl Are Infrequently Detected in Human Mammary Tissue by Liquid Chromatography/Tandem Mass Spectrometry. Carcinogenesis 2012, 33 (1), 124–130. PubMed.
Chen, C.-H.; Dickman, K. G.; Moriya, M.; Zavadil, J.; Sidorenko, V. S.; Edwards, K. L.; Gnatenko, D. V.; Wu, L.; Turesky, R. J.; Wu, X.-R.; et al. Aristolochic Acid-Associated Urothelial Cancer in Taiwan. Proc. Natl. Acad. Sci. U. S. A. 2012, 109 (21), 8241–8246. PubMed.
Turesky, R. J.; Bendaly, J.; Yasa, I.; Doll, M. A.; Hein, D. W. The Impact of NAT2 Acetylator Genotype on Mutagenesis and DNA Adducts from 2-Amino-9H-pyrido[2,3-B]indole. Chem. Res. Toxicol. 2009, 22 (4), 726–733. PubMed.
Goodenough, A. K.; Schut, H. A. J.; Turesky, R. J. Novel LC-ESI/MS/MSn Method for the Characterization and Quantification of 2‘-Deoxyguanosine Adducts of the Dietary Carcinogen 2-Amino-1-Methyl-6-phenylimidazo[4,5-B]pyridine by 2-D Linear Quadrupole Ion Trap Mass Spectrometry. Chem. Res. Toxicol. 2007, 20 (2), 263–276. PubMed.
Turesky, R. J.; Le Marchand, L. Metabolism and Biomarkers of Heterocyclic Aromatic Amines in Molecular Epidemiology Studies: Lessons Learned from Aromatic Amines. Chem. Res. Toxicol. 2011, 24 (8), 1169–1214. PubMed.
Nauwelaers, G.; Bessette, E. E.; Gu, D.; Tang, Y.; Rageul, J.; Fessard, V.; Yuan, J.-M.; Yu, M. C.; Langouët, S.; Turesky, R. J. DNA Adduct Formation of 4-Aminobiphenyl and Heterocyclic Aromatic Amines in Human Hepatocytes. Chem. Res. Toxicol. 2011, 24 (6), 913–925. PubMed.
Bessette, E. E.; Spivack, S. D.; Goodenough, A. K.; Wang, T.; Pinto, S.; Kadlubar, F. F.; Turesky, R. J. Identification of Carcinogen DNA Adducts in Human Saliva by Linear Quadrupole Ion Trap/Multistage Tandem Mass Spectrometry. Chem. Res. Toxicol. 2010, 23 (7), 1234–1244. PubMed.
Bessette, E. E.; Goodenough, A. K.; Langouët, S.; Yasa, I.; Kozekov, I. D.; Spivack, S. D.; Turesky, R. J. Screening for DNA Adducts by Data-Dependent Constant Neutral Loss-Triple Stage Mass Spectrometry with a Linear Quadrupole Ion Trap Mass Spectrometer. Anal. Chem. 2009, 81 (2), 809–819. PubMed.
© Regents of the University of Minnesota. All rights reserved. The University of Minnesota is an equal opportunity educator and employer.
Twin Cities Campus: Parking & Transportation | Maps & Directions | Directories | Contact U of M | Privacy