Publications
2024
Jokipii Krueger, C. C.; Park, S. L.; Patel, Y.; Stram, D. O.; Aldrich, M.; Cai, Q.; Tretyakova, N. Y. Association of Urinary N7-(1-Hydroxyl-3-Buten-1-Yl) Guanine (EB-GII) Adducts and Butadiene-Mercapturic Acids with Lung Cancer Development in Cigarette Smokers. Chem Res Toxicol 2024, 37 (2), 374–384. https://doi.org/10.1021/acs.chemrestox.3c00336.
2023
Rajczewski, A. T.; Ndreu, L.; Vryonidis, E.; Hurben, A. K.; Jamshidi, S.; Griffin, T. J.; Törnqvist, M. Å.; Tretyakova, N. Y.; Karlsson, I. Mass Spectrometry-Based Strategies for Assessing Human Exposure Using Hemoglobin Adductomics. Chem Res Toxicol 2023, 36 (12), 2019–2030. https://doi.org/10.1021/acs.chemrestox.3c00294.
Jokipii Krueger, C. C.; Moran, E.; Tessier, K. M.; Tretyakova, N. Y. Isotope Labeling Mass Spectrometry to Quantify Endogenous and Exogenous DNA Adducts and Metabolites of 1,3-Butadiene In Vivo. Chem Res Toxicol 2023, 36 (8), 1409–1418. https://doi.org/10.1021/acs.chemrestox.3c00141.
Essawy, M.; Chesner, L.; Alshareef, D.; Ji, S.; Tretyakova, N.; Campbell, C. Ubiquitin Signaling and the Proteasome Drive Human DNA-Protein Crosslink Repair. Nucleic Acids Res 2023, 51 (22), 12174–12184. https://doi.org/10.1093/nar/gkad860.
Zhang, Q.; Tretyakova, N. Incorporation of Inosine into DNA by Human Polymerase Eta (Polη): Kinetics of Nucleotide Misincorporation and Structural Basis for the Mutagenicity. Biochem J 2023, 480 (18), 1479–1483. https://doi.org/10.1042/BCJ20230159.
Ndreu, L.; Hurben, A. K.; Nyman, G. S. A.; Tretyakova, N. Y.; Karlsson, I.; Hagvall, L. Investigation into Propolis Components Responsible for Inducing Skin Allergy: Air Oxidation of Caffeic Acid and Its Esters Contribute to Hapten Formation. Chem Res Toxicol 2023, 36 (6), 859–869. https://doi.org/10.1021/acs.chemrestox.2c00386.
Martella, G.; Gorokhova, E.; Sousa, P. F. M.; Tretyakova, N. Y.; Sundelin, B.; Motwani, H. V. DNA Adductomics for the Biological Effect Assessment of Contaminant Exposure in Marine Sediments. Environ. Sci. Technol. 2023, 57 (29), 10591–10603. https://doi.org/10.1021/acs.est.3c00499.
2022
Kirman, C. R.; North, C. M.; Tretyakova, N. Y.; Erraguntla, N.; Shen, H.; Hays, S. M. Use of Biomarker Data and Metabolite Relative Potencies to Support Derivation of Noncancer Reference Values Based on the Reproductive and Developmental Toxicity Effects of 1,3-Butadiene. Regul. Toxicol. Pharmacol. 2022, 105239. https://doi.org/10.1016/j.yrtph.2022.105239.
Weirath, N. A.; Hurben, A. K.; Chao, C.; Pujari, S. S.; Cheng, T.; Liu, S.; Tretyakova, N. Y. Small Molecule Inhibitors of TET Dioxygenases: Bobcat339 Activity Is Mediated by Contaminating Copper(II). ACS Med. Chem. Lett. 2022, 13 (5), 792–798. https://doi.org/10.1021/acsmedchemlett.1c00677
Rajczewski, A. T.; Han, Q.; Mehta, S.; Kumar, P.; Jagtap, P. D.; Knutson, C. G.; Fox, J. G.; Tretyakova, N. Y.; Griffin, T. J. Quantitative Proteogenomic Characterization of Inflamed Murine Colon Tissue Using an Integrated Discovery, Verification, and Validation Proteogenomic Workflow. Proteomes 2022, 10 (2), 11. https://doi.org/10.3390/proteomes10020011.
Wang, X.; Sarver, A. L.; Han, Q.; Seiler, C. L.; Xie, C.; Lu, H.; Forster, C. L.; Tretyakova, N. Y.; Hallstrom, T. C. UHRF2 Regulates Cell Cycle, Epigenetics and Gene Expression to Control the Timing of Retinal Progenitor and Ganglion Cell Differentiation. Development 2022, 149 (6). https://doi.org/10.1242/dev.195644.
Pujari, S. S.; Jokipii Krueger, C. C.; Chao, C.; Hutchins, S.; Hurben, A. K.; Boysen, G.; Tretyakova, N. DEB-FAPy-DG Adducts of 1,3-Butadiene: Synthesis, Structural Characterization, and Formation in 1,2,3,4-Diepoxybutane Treated DNA**. Chem. – Eur. J. 2022, 28 (3). https://doi.org/10.1002/chem.202103245.
Hurben, A. K.; Ge, P.; Bouchard, J. L.; Doran, T. M.; Tretyakova, N. Y. Photocaged Dicarbonyl Probe Provides Spatiotemporal Control over Protein Glycation. Chem. Commun. 2022, 58 (6), 855–858.
Cheng, T.; Zhou, C.; Pang, J.; Tretyakova, N.; William, W. T.; Liu, Y.; Liu, S. Coordinated Activation of DNMT3a and TET2 in Cancer Stem Cell-like Cells Initiates and Sustains Drug Resistance in Hepatocellular Carcinoma. 2022.
2021
Erber, L.; Goodman, S.; Wright, F. A.; Chiu, W. A.; Tretyakova, N. Y.; Rusyn, I. Intra- and Inter-Species Variability in Urinary N7-(1-Hydroxy-3-Buten-2-Yl)Guanine Adducts Following Inhalation Exposure to 1,3-Butadiene. Chem. Res. Toxicol. 2021, 34 (11), 2375–2383. https://doi.org/10.1021/acs.chemrestox.1c00291.
Pujari, S.S.; Jokipii Krueger, C.C.; Chao, C.; Hutchins, S.; Hurben, A.K.; Boysen, G.; and Tretyakova, N.Y. DEB-FAPy-dG Adducts of 1,3-Butadiene: Synthesis, Structural Characterization, and Formation in 1,2,3,4-Diepoxybutane Treated DNA. Chemistry - A European Journal 2021, in press. https://doi.org/10.1002/chem.202103245
Pujari, S.S.; Wu, M.; Thomforde, J.; Wang, Z.A.; Chao, C.; Olson, N.; Erber, L.; Pomerantz, W.C.K.; Cole, P.; Tretyakova, N.Y. Site-Specific 5-Formyl Cytosine Mediated DNA-Histone Cross-Links: Synthesis and Polymerase Bypass by Human DNA Polymerase η. Angewandte Chemie 2021, 60, 26489-26494. https://doi.org/10.1002/anie.202109418
Hurben, A.; Erber, L.; Tretyakova, N.; Doran, T. Proteome-wide Profiling of Cellular Targets Modified by Dopamine Metabolites using a Bio-orthogonally Functionalized Catecholamine. ACS Chem Biol 2021, 16 (11), 2581-2594. https://doi.org/10.1021/acschembio.1c00629
Erber, L.; Goodman, S.; Jokipii Krueger, C.C.; Rusyn, I.; Tretyakova, N. Quantitative Nano LC/NSI+-HRMS method for 1,3-butadiene induced bis-N7-guanine DNA-DNA crosslinks in urine. Toxics 2021, 9, 247. https://doi.org/10.3390/toxics9100247
Rajczewski, A.T.; Ndreu, L.; Pujari, S.S.; Griffin, T.J.; Törnqvist, M.; Karlsson, I.; Tretyakova, N. Novel 4-Hydroxybenzyl Adducts in Human Hemoglobin: Structures and Mechanisms of Formation. Chem Res Toxicol 2021, 34 (7), 1769-1781. https://doi.org/10.1021/acs.chemrestox.1c00111
Thomforde, J.; Fu, I.; Rodriguez, F.; Pujari, S.S.; Broyde, S.; Tretyakova, N. Translesion Synthesis Past 5-Formylcytosine-Mediated DNA-Peptide Cross-Links by hPolη Is Dependent on the Local DNA Sequence. Biochemistry 2021, 60 (23), 1797-1807. https://doi.org/10.1021/acs.biochem.1c00130
Jokipii Krueger, C. C.; Park, S. L.; Madugundu, G.; Patel, Y.; Le Marchand, L.; Stram, D. O.; Tretyakova, N. Y. Ethnic Differences in Excretion of Butadiene-DNA Adducts by Current Smokers. Carcinogenesis 2021, 42 (5), 694-704. https://doi.org/10.1093/carcin/bgab020
Boysen, G.; Arora, R.; Degner, A.; Vevang, K. R.; Chao, C.; Rodriguez, F.; Walmsley, S. J.; Erber, L.; Tretyakova, N. Y.; Peterson, L. A. Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Cross-Links in Human Hapmap Cell Lines. Chemical Research in Toxicology 2021, 34 (1), 119–131. https://doi.org/10.1021/acs.chemrestox.0c00376.
Han, Q.; Kono, T.J.Y.; Knutson, C.G.; Parry, N.M.; Seiler, C.L.; Fox, J.G.; Tannenbaum, S.R.; Tretyakova, N.Y. Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the Rag2−/−/Il10−/− Mouse Model. Int. J. Mol. Sci. 2021, 22, 364. https://doi.org/10.3390/ijms22010364
Books and chapters
Guza, R., Pegg, A., and Tretyakova, N.Y. (2010) Effects of sequence context on O6-alkylguanine DNA alkyltransferase repair of O6-alkylguanine-deoxyguanosine adducts. In ACS Symposium Series, Volume 1041, Structural Biology of DNA Damage and Repair (Stone, M.P., Ed.) pp 73-101, American Chemical Society, Washington, D.C.
Tretyakova, N.Y. (2009) Sequence distribution of nucleobase adducts studied by isotope labeling of DNA-mass spectrometry. In Mass Spectrometry of Nucleosides and Nucleic Acids (Banoub, J.H. and Limbach, P.A., Eds.), CRC Press, Boca Raton, FL.
Malejka-Giganti, M. and Tretyakova, N.Y. (2006) Molecular mechanisms of carcinogenesis. In Carcinogenic and anticarcinogenic food components. (Baer-Dubowska, W., Bartoszek, A., and Malejka-Giganti, D. Eds.), pp 13-36, CRC Press, Boca Raton, FL.
Active Collaborations
Prof. Colin Campbell (Pharmacology) - DNA-protein cross-linking by bis-electrophiles
Prof. Darrin York (Chemistry) - Molecular modeling of chemically modified nucleic acids
Prof. D. Malejka-Giganti (VA Medical Center) - Oxidative DNA damage and cancer
Prof. Roger Jones (Rutgers) - Stable isotope labeling of DNA
2011-2020
2020
Ndreu, L.; Erber, L. N.; Törnqvist, M.; Tretyakova, N. Y.; Karlsson, I. Characterizing Adduct Formation of Electrophilic Skin Allergens with Human Serum Albumin and Hemoglobin. Chemical Research in Toxicology 2020, 33 (10), 2623–2636. https://doi.org/10.1021/acs.chemrestox.0c00271.
Seiler, C. L.; Song, J. ung M.; Kotandeniya, D.; Chen, J.; Kono, T. J. Y.; Han, Q.; Colwell, M.; Auch, B.; Sarver, A. L.; Upadhyaya, P.; Ren, Y.; Faulk, C.; de Flora, S.; la Maestra, S.; Chen, Y.; Kassie, F.; Tretyakova, N. Y. Inhalation Exposure to Cigarette Smoke and Inflammatory Agents Induces Epigenetic Changes in the Lung. Scientific Reports 2020, 10 (1), 11290. https://doi.org/10.1038/s41598-020-67502-8.
Degner, A.; Arora, R.; Erber, L.; Chao, C.; Peterson, L. A.; Tretyakova, N. Y. Interindividual Differences in DNA Adduct Formation and Detoxification of 1,3-Butadiene-Derived Epoxide in Human HapMap Cell Lines. Chemical Research in Toxicology 2020, 33 (7), 1698–1708. https://doi.org/10.1021/acs.chemrestox.9b00517.
Peterson, L. A.; Balbo, S.; Fujioka, N.; Hatsukami, D. K.; Hecht, S. S.; Murphy, S. E.; Stepanov, I.; Tretyakova, N. Y.; Turesky, R. J.; Villalta, P. W. Applying Tobacco, Environmental, and Dietary-Related Biomarkers to Understand Cancer Etiology and Evaluate Prevention Strategies. Cancer Epidemiology Biomarkers & Prevention 2020, 29 (10), 1904–1919. https://doi.org/10.1158/1055-9965.epi-19-1356.
Gorokhova, E.; Martella, G.; Motwani, N. H.; Tretyakova, N. Y.; Sundelin, B.; Motwani, H. v. DNA Epigenetic Marks Are Linked to Embryo Aberrations in Amphipods. Scientific Reports 2020, 10 (1), 1–11. https://doi.org/10.1038/s41598-020-57465-1.
Boldry, E. J.; Yuan, J. M.; Carmella, S. G.; Wang, R.; Tessier, K.; Hatsukami, D. K.; Hecht, S. S.; Tretyakova, N. Y. Effects of 2-Phenethyl Isothiocyanate on Metabolism of 1,3-Butadiene in Smokers. Cancer Prevention Research 2020, 13 (1), 91–100. https://doi.org/10.1158/1940-6207.CAPR-19-0296.
Jokipii Krueger, C. C.; Madugundu, G.; Degner, A.; Patel, Y.; Stram, D. O.; Church, T. R.; Tretyakova, N. Urinary N7-(1-Hydroxy-3-Buten-2-Yl) Guanine Adducts in Humans: Temporal Stability and Association with Smoking. Mutagenesis 2020, 35 (1), 19–26. https://doi.org/10.1093/mutage/gez030.
2019
Ji, S.; Park, D.; Kropachev, K.; Kolbanovskiy, M.; Fu, I.; Broyde, S.; Essawy, M.; Geacintov, N. E.; Tretyakova, N. Y. 5-Formylcytosine-Induced DNA–Peptide Cross-Links Reduce Transcription Efficiency, but Do Not Cause Transcription Errors in Human Cells. Journal of Biological Chemistry 2019, 294 (48), 18387–18397. https://doi.org/10.1074/jbc.RA119.009834.
Ji, S.; Thomforde, J.; Rogers, C.; Fu, I.; Broyde, S.; Tretyakova, N. Y. Transcriptional Bypass of DNA-Protein and DNA-Peptide Conjugates by T7 RNA Polymerase. ACS Chemical Biology 2019, 14 (12), 2564–2575. https://doi.org/10.1021/acschembio.9b00365.
Naldiga, S.; Ji, S.; Thomforde, J.; Nicolae, C. M.; Lee, M.; Zhang, Z.; Moldovan, G. L.; Tretyakova, N. Y.; Basu, A. K. Error-Prone Replication of a 5-Formylcytosine-Mediated DNA-Peptide Cross-Link in Human Cells. Journal of Biological Chemistry 2019, 294 (27), 10619–10627. https://doi.org/10.1074/jbc.RA119.008879.
Seiler, C. L.; Song, J. M.; Fernandez, J.; Abrahante, J. E.; Kono, T. J. Y.; Chen, Y.; Ren, Y.; Kassie, F.; Tretyakova, N. Y. Epigenetic Changes in Alveolar Type II Lung Cells of A/J Mice Following Intranasal Treatment with Lipopolysaccharide. Chemical Research in Toxicology 2019, 32 (5), 831–839. https://doi.org/10.1021/acs.chemrestox.9b00015.
Seiler, C.L., Fernandez, J., Han, Q., Tretyakova, N. Experimental Methodologies for Detection and Mapping of Epigenetic DNA Marks. Invited Springer Book Chapter.
2018
Kotandeniya, D.; Seiler, C. L.; Fernandez, J.; Pujari, S. S.; Curwick, L.; Murphy, K.; Wickramaratne, S.; Yan, S.; Murphy, D.; Sham, Y. Y.; Tretyakova, N. Y. Can 5 Methylcytosine Analogues with Extended Alkyl Side Chains Guide DNA Methylation? Chemical Communications 2018, 54 (9), 1061–1064. https://doi.org/10.1039/c7cc06867k.
Matter, B.; Seiler, C. L.; Murphy, K.; Ming, X.; Zhao, J.; Lindgren, B.; Jones, R.; Tretyakova, N. Mapping Three Guanine Oxidation Products along DNA Following Exposure to Three Types of Reactive Oxygen Species. Free Radical Biology and Medicine 2018, 121, 180–189. https://doi.org/10.1016/j.freeradbiomed.2018.04.561.
Groehler, A.; Kren, S.; Li, Q.; Robledo-Villafane, M.; Schmidt, J.; Garry, M.; Tretyakova, N. Oxidative Cross-Linking of Proteins to DNA Following Ischemia-Reperfusion Injury. Free Radical Biology and Medicine 2018, 120, 89–101. https://doi.org/10.1016/j.freeradbiomed.2018.03.010.
Ji, S.; Fu, I.; Naldiga, S.; Shao, H.; Basu, A. K.; Broyde, S.; Tretyakova, N. Y. 5-Formylcytosine Mediated DNA-Protein Cross-Links Block DNA Replication and Induce Mutations in Human Cells. Nucleic Acids Research 2018, 46 (13), 6455–6469. https://doi.org/10.1093/nar/gky444.
Pujari, S. S.; Zhang, Y.; Ji, S.; Distefano, M. D.; Tretyakova, N. Y. Site-Specific Cross-Linking of Proteins to DNA Via a New Bioorthogonal Approach Employing Oxime Ligation. Chemical Communications 2018, 54 (49), 6296–6299. https://doi.org/10.1039/c8cc01300d.
Groehler, A. S.; Najjar, D.; Pujari, S. S.; Sangaraju, D.; Tretyakova, N. Y. N 6 -(2-Deoxy- d - Erythro-Pentofuranosyl)-2,6-Diamino-3,4-Dihydro-4-Oxo-5- N-(2-Hydroxy-3-Buten-1-Yl)-Formamidopyrimidine Adducts of 1,3-Butadiene: Synthesis, Structural Identification, and Detection in Human Cells. Chemical Research in Toxicology 2018, 31 (9), 885–897. https://doi.org/10.1021/acs.chemrestox.8b00123.
Seiler, C. L.; Fernandez, J.; Koerperich, Z.; Andersen, M. P.; Kotandeniya, D.; Nguyen, M. E.; Sham, Y. Y.; Tretyakova, N. Y. Maintenance DNA Methyltransferase Activity in the Presence of Oxidized Forms of 5-Methylcytosine: Structural Basis for Ten Eleven Translocation-Mediated DNA Demethylation. Biochemistry 2018, 57 (42), 6061–6069. https://doi.org/10.1021/acs.biochem.8b00683.
Hrit, J.; Goodrich, L.; Li, C.; Wang, B. A.; Nie, J.; Cui, X.; Martin, E. A.; Simental, E.; Fernandez, J.; Liu, M. Y.; Nery, J. R.; Castanon, R.; Kohli, R. M.; Tretyakova, N.; He, C.; Ecker, J. R.; Goll, M.; Panning, B. OGT Binds a Conserved C-Terminal Domain of TET1 to Regulate TET1 Activity and Function in Development. eLife 2018, 7. https://doi.org/10.7554/eLife.34870.
Degner, A.; Carlsson, H.; Karlsson, I.; Eriksson, J.; Pujari, S. S.; Tretyakova, N. Y.; Törnqvist, M. Discovery of Novel N-(4-Hydroxybenzyl)Valine Hemoglobin Adducts in Human Blood. Chemical Research in Toxicology 2018, 31 (12), 1305–1314. https://doi.org/10.1021/acs.chemrestox.8b00173.
2017
Pande, P.; Ji, S.; Mukherjee, S.; Schärer, O. D.; Tretyakova, N. Y.; Basu, A. K. Mutagenicity of a Model DNA-Peptide Cross-Link in Human Cells: Roles of Translesion Synthesis DNA Polymerases. Chemical Research in Toxicology 2017, 30 (2), 669–677. https://doi.org/10.1021/acs.chemrestox.6b00397.
Ji, S.; Shao, H.; Han, Q.; Seiler, C. L.; Tretyakova, N. Y. Reversible DNA-Protein Cross-Linking at Epigenetic DNA Marks. Angewandte Chemie International Edition 2017, 56 (45), 14130–14134. https://doi.org/10.1002/anie.201708286.
Chesner, L. N.; Degner, A.; Sangaraju, D.; Yomtoubian, S.; Wickramaratne, S.; Malayappan, B.; Tretyakova, N.; Campbell, C. Cellular Repair of DNA–DNA Cross-Links Induced by 1,2,3,4-Diepoxybutane. International Journal of Molecular Sciences 2017, 18 (5). https://doi.org/10.3390/ijms18051086.
Chang, S. C.; Seneviratne, U. I.; Wu, J.; Tretyakova, N.; Essigmann, J. M. 1,3-Butadiene-Induced Adenine DNA Adducts Are Genotoxic but Only Weakly Mutagenic When Replicated in Escherichia Coli of Various Repair and Replication Backgrounds. Chemical Research in Toxicology 2017, 30 (5), 1230–1239. https://doi.org/10.1021/acs.chemrestox.7b00064.
Pang, J.; Shen, N.; Yan, F.; Zhao, N.; Dou, L.; Wu, L. C.; Seiler, C. L.; Yu, L.; Yang, K.; Bachanova, V.; Weaver, E.; Tretyakova, N. Y.; Liu, S. Thymoquinone Exerts Potent Growth-Suppressive Activity on Leukemia through DNA Hypermethylation Reversal in Leukemia Cells. Oncotarget 2017, 8 (21), 34453–34467. https://doi.org/10.18632/oncotarget.16431.
Ming, X.; Groehler, A.; Michaelson-Richie, E. D.; Villalta, P. W.; Campbell, C.; Tretyakova, N. Y. Mass Spectrometry Based Proteomics Study of Cisplatin-Induced DNA-Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells. Chemical Research in Toxicology 2017, 30 (4), 980–995. https://doi.org/10.1021/acs.chemrestox.6b00389.
Boldry, E. J.; Patel, Y. M.; Kotapati, S.; Esades, A.; Park, S. L.; Tiirikainen, M.; Stram, D. O.; le Marchand, L.; Tretyakova, N. Genetic Determinants of 1,3-Butadiene Metabolism and Detoxification in Three Populations of Smokers with Different Risks of Lung Cancer. Cancer Epidemiology Biomarkers and Prevention 2017, 26 (7), 1034–1042. https://doi.org/10.1158/1055-9965.EPI-16-0838.
Groehler, A.; Degner, A.; Tretyakova, N. Y. Mass Spectrometry-Based Tools to Characterize DNA–Protein Cross-Linking by Bis-Electrophiles. Basic and Clinical Pharmacology and Toxicology. Blackwell Publishing Ltd September 1, 2017, pp 63–77. https://doi.org/10.1111/bcpt.12751.
Sangaraju, D.; Boldry, E. J.; Patel, Y. M.; Walker, V.; Stepanov, I.; Stram, D.; Hatsukami, D.; Tretyakova, N. Isotope Dilution NanoLC/ESI+-HRMS3 Quantitation of Urinary N7-(1-Hydroxy-3-Buten-2-Yl) Guanine Adducts in Humans and Their Use as Biomarkers of Exposure to 1,3-Butadiene. Chemical Research in Toxicology 2017, 30 (2), 678–688. https://doi.org/10.1021/acs.chemrestox.6b00407.
Pujari, S. S.; Tretyakova, N. Chemical Biology of N5-Substituted Formamidopyrimidine DNA Adducts. Chemical Research in Toxicology. American Chemical Society January 17, 2017, pp 434–452. https://doi.org/10.1021/acs.chemrestox.6b00392.
2016
Wickramaratne, S., Ji, S., Mukherjee, S., Su, Y., Pence, M.G., Lior-Hoffmann, L., Fu, I., Broyde, S., Guengerich, F.P., Distefano, M., Scharer, O.D., Sham, Y.Y., and Tretyakova, N.Y. (2016) Bypass of DNA-protein cross-links conjugated to the 7-deazaguanine position of DNA by translesion synthesis polymerases. J. Biol. Chem. 291, 23589-23603. PubMed
Wickramaratne, S., Banda, D.M., Ji, S., Manlove, A.H., Malayappan, B., Nunez, N.N., Samson, L., Campbell, C., David, S.S., and Tretyakova, N.Y. (2016) Base excision repair of N6-deoxyadenosine adducts of 1,3-butadiene. Biochemistry. 55, 6070-6081. PubMed
Ming, X., Michaelson, E., Campbell, C., and Tretyakova, N.Y. (2016) DNA-Protein cross-linking by 1,1,2,2-cis-diammine-dichloroplatium(II) (cisplatin). Chem. Res. Toxicol. Accepted.
Groehler, A., Villalta, P.W., Campbell, C., and Tretyakova, N.Y. (2016) Covalent DNA-protein cross-linking by phosphoramide mustard and nornitrogen mustard in human cells. Chem. Res. Toxicol. 29, 190-202. PubMed
2015
Wickramaratne, S., Seiler, C.L., and Tretyakova, N.Y. (2015) Synthesis of DNA oligodeoxynucleotides containing site-specific 1,3-butadiene-deoxyadenosine lesions. Curr Protoc Nucleic Acid Chem. 61, 4.61.1-4.61.22. PubMed
Wickramaratne, S., Boldry, E.J., Buehler, C., Wang, Y.C., Distefano, M.D., and Tretyakova, N.Y. (2015) Error-prone translesion synthesis past DNA-peptide cross-links conjugated to the major groove of DNA via C5 of thymidine. J. Biol. Chem. 290, 775-87. PubMed
Tretyakova, N.Y., Groehler, A., and Ji, S. (2015) DNA-protein cross-links: Formation, structural identities, and biological outcomes. Acc. Chem. Res. 48, 1631-44. PubMed
McFaline-Figueroa, J.L., Braun, C.J., Stanciu, M., Nagel, Z.D., Mazzucato, P., Sangaraju, D., Cerniauskas, E., Barford, K., Vargas, A., Chen, Y., Tretyakova, N.Y., Lees, J.A., Hemann, M.T., White, F.M., and Samson, L.D. (2015) Minor changes in expression of the mismatch repair protein MSH2 exert a major impact on glioblastoma response to temozolomide. Cancer Res. 75, 3127-38. PubMed
Kotapati, S., Wickramaratne, S., Esades, A., Boldry, E.J., Quirk-Dorr, D., Pence, M.G., Guengerich, F.P., and Tretyakova, N.Y. (2015) Polymerase bypass of N6-deoxyadenosine adducts derived from epoxide metabolites of 1,3-butadiene. Chem. Res. Toxicol. 28, 1496-507. PubMed
Kotapati, S., Esades, A., Matter, B., Le, C., and Tretyakova, N.Y. (2015) High throughput HPLC-ESI--MS/MS methodology for mercapturic acid metabolites of 1,3-butadiene: Biomarkers of exposure and bioactivation. Chem Biol Interact. 241, 23-31. PubMed
2014
Yeo, J.E., Wickramaratne, S., Khatwani, S., Wang, Y.C., Vervacke, J., Distefano, M.D., and Tretyakova, N.Y. (2014) Synthesis of site-specific DNA-protein conjugates and their effects on DNA replication. ACS Chem. Biol. 9, 1860-8. PubMed
Wickramaratne, S., and Tretyakova, N.Y. (2014) Structure elucidation of DNA-protein crosslinks by using reductive desulfurization and liquid chromatography-tandem mass spectrometry. ChemBioChem. 15, 353-5. PubMed
Sangaraju, D., Villalta, P.W., Wickramaratne, S., Swenberg, J., and Tretyakova, N.Y. (2014) NanoLC/ESI+ HRMS3 quantitation of DNA adducts induced by 1,3-butadiene. J. Am. Soc. Mass Spectrom. 25, 1124-35. PubMed
Park, S.L., Kotapati, S., Wilkens, L.R., Tiirikainen, M., Murphy, S.E., Tretyakova, N.Y., and Le Marchand, L. (2014) 1,3-Butadiene exposure and metabolism among Japanese American, Native Hawaiian, and White smokers. Cancer Epidemiol. Biomarkers Prev. 23, 2240-9. PubMed
Ming, X., Matter, B., Song, M., Veliath, E., Shanley, R., Jones, R., and Tretyakova, N.Y. (2014) Mapping structurally defined guanine oxidation products along DNA duplexes: influence of local sequence context and endogenous cytosine methylation. J. Am. Chem. Soc. 136, 4223-35. PubMed
Kowal, E.A., Wickramaratne, S., Kotapati, S., Turo, M., Tretyakova, N.Y., and Stone, M.P. (2014) Major groove orientation of the (2S)-N6-(2-hydroxy-3-buten-1-yl)-2'-deoxyadenosine DNA adduct induced by 1,2-epoxy-3-butene. Chem. Res. Toxicol. 27, 1675-86. PubMed
Kowal, E.A., Seneviratne, U., Wickramaratne, S., Doherty, K.E., Cao, X., Tretyakova, N.Y., and Stone, M.P. (2014) Structures of exocyclic R,R- and S,S-N6,N6-(2,3-dihydroxybutan-1,4-diyl)-2'-deoxyadenosine adducts induced by 1,2,3,4-diepoxybutane. Chem. Res. Toxicol. 27, 805-17. PubMed
Kotapati, S., Sangaraju, D., Esades, A., Hallberg, L., Walker, V.E., Swenberg, J.A., and Tretyakova, N.Y. (2014) Bis-butanediol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species. Carcinogenesis. 35, 1371-8. PubMed
Chappell, G., Kobets, T., O'Brien, B., Tretyakova, N.Y., Sangaraju, D., Kosyk, O., Sexton, K.G., Bodnar, W., Pogribny, I.P., and Rusyn, I. (2014) Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice. Toxicol. Sci. 142, 375-84. PubMed
2013
Wickramaratne, S., Mukherjee, S., Villalta, P.W., Scharer, O.D., and Tretyakova, N.Y. (2013) Synthesis of sequence-specific DNA-protein conjugates via a reductive amination strategy. Bioconjug Chem. 24, 1496-506. PubMed
Tretyakova, N.Y., Villalta, P.W., and Kotapati, S. (2013) Mass spectrometry of structurally modified DNA. Chem. Rev. 113, 2395-436. PubMed
Tretyakova, N.Y., Michaelson-Richie, E.D., Gherezghiher, T.B., Kurtz, J., Ming, X., Wickramaratne, S., Campion, M., Kanugula, S., Pegg, A.E., and Campbell, C. (2013) DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells. Biochemistry. 52, 3171-81. PubMed
Sangaraju, D., Villalta, P., Goggin, M., Agunsoye, M.O., Campbell, C., and Tretyakova, N.Y. (2013) Capillary HPLC-accurate mass MS/MS quantitation of N7-(2,3,4-trihydroxybut-1-yl)-guanine adducts of 1,3-butadiene in human leukocyte DNA. Chem. Res. Toxicol. 26, 1486-97. PubMed
Kotandeniya, D., Murphy, D., Yan, S., Park, S., Seneviratne, U., Koopmeiners, J.S., Pegg, A., Kanugula, S., Kassie, F., and Tretyakova, N.Y. (2013) Kinetics of O6-pyridyloxobutyl-2'-deoxyguanosine repair by human O6-alkylguanine DNA alkyltransferase. Biochemistry. 52, 4075-88. PubMed
Gherezghiher, T.B., Ming, X., Villalta, P.W., Campbell, C., and Tretyakova, N.Y. (2013) 1,2,3,4-Diepoxybutane-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells. J. Proteome Res. 12, 2151-64. PubMed
Burns, M.B., Lackey, L., Carpenter, M.A., Rathore, A., Land, A.M., Leonard, B., Refsland, E.W., Kotandeniya, D., Tretyakova, N.Y., Nikas, J.B., Yee, D., Temiz, N.A., Donohue, D.E., McDougle, R.M., Brown, W.L., Law, E.K., and Harris, R.S. (2013) APOBEC3B is an enzymatic source of mutation in breast cancer. Nature. 494, 366-70. PubMed
2012
Tretyakova, N.Y., Goggin, M., Sangaraju, D., and Janis, G. (2012) Quantitation of DNA adducts by stable isotope dilution mass spectrometry. Chem. Res. Toxicol. 25, 2007-35. PubMed
Sangaraju, D., Goggin, M., Walker, V., Swenberg, J., and Tretyakova, N.Y. (2012) NanoHPLC-nanoESI+-MS/MS quantitation of bis-N7-guanine DNA-DNA cross-links in tissues of B6C3F1 mice exposed to subppm levels of 1,3-butadiene. Anal. Chem. 84, 1732-9. PubMed
Kotapati, S., Maddukuri, L., Wickramaratne, S., Seneviratne, U., Goggin, M., Pence, M.G., Villalta, P., Guengerich, F.P., Marnett, L., and Tretyakova, N.Y. (2012) Translesion synthesis across 1,N6-(2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-gamma-HMHP-dA) adducts by human and archebacterial DNA polymerases. J. Biol. Chem. 287, 38800-11. PubMed
Johnson, L.A., Malayappan, B., Tretyakova, N.Y., Campbell, C., MacMillan, M.L., Wagner, J.E., and Jacobson, P.A. (2012) Formation of cyclophosphamide specific DNA adducts in hematological diseases. Pediatr. Blood Cancer. 58, 708-14. PubMed
2011
Swenberg, J.A., Bordeerat, N.K., Boysen, G., Carro, S., Georgieva, N.I., Nakamura, J., Troutman, J.M., Upton, P.B., Albertini, R.J., Vacek, P.M., Walker, V.E., Sram, R.J., Goggin, M., and Tretyakova, N.Y. (2011) 1,3-Butadiene: Biomarkers and application to risk assessment. Chem Biol Interact. 192, 150-4. PubMed
Michaelson-Richie, E.D., Ming, X., Codreanu, S.G., Loeber, R.L., Liebler, D.C., Campbell, C., and Tretyakova, N.Y. (2011) Mechlorethamine-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells. J. Proteome Res. 10, 2785-96. PubMed
Kotapati, S., Matter, B.A., Grant, A.L., and Tretyakova, N.Y. (2011) Quantitative analysis of trihydroxybutyl mercapturic acid, a urinary metabolite of 1,3-butadiene, in humans. Chem. Res. Toxicol. 24, 1516-26. PubMed
Kotandeniya, D., Murphy, D., Seneviratne, U., Guza, R., Pegg, A., Kanugula, S., and Tretyakova, N.Y. (2011) Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA. Chem. Res. Toxicol. 24, 1966-75. PubMed
Guza, R., Kotandeniya, D., Murphy, K., Dissanayake, T., Lin, C., Giambasu, G.M., Lad, R.R., Wojciechowski, F., Amin, S., Sturla, S.J., Hudson, R.H., York, D.M., Jankowiak, R., Jones, R., and Tretyakova, N.Y. (2011) Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA. Nucleic Acids Res. 39, 3988-4006. PubMed
Goggin, M., Sangaraju, D., Walker, V.E., Wickliffe, J., Swenberg, J.A., and Tretyakova, N.Y. (2011) Persistence and repair of bifunctional DNA adducts in tissues of laboratory animals exposed to 1,3-butadiene by inhalation. Chem. Res. Toxicol. 24, 809-17. PubMed
2001 - 2010
2010
Seneviratne, U., Antsypovich, S., Quirk-Dorr, D., Dissanayake, T., Kotapati, S., and Tretyakova, N.Y. (2010) DNA oligomers containing site-specific and stereospecific exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, characterization, and effects on DNA structure. Chem. Res. Toxicol. 23, 1556-67. PubMed
Seneviratne, U., Antsypovich, S., Goggin, M., Quirk-Dorr, D., Guza, R., Moser, A., Thompson, C., York, D.M., and Tretyakova, N.Y. (2010) Exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, structural elucidation, and mechanistic studies. Chem. Res. Toxicol. 23, 118-33. PubMed
Michaelson-Richie, E.D., Loeber, R.L., Codreanu, S.G., Ming, X., Liebler, D.C., Campbell, C., and Tretyakova, N.Y. (2010) DNA-protein cross-linking by 1,2,3,4-diepoxybutane. J. Proteome Res. 9, 4356-67. PubMed
Malayappan, B., Johnson, L., Nie, B., Panchal, D., Matter, B., Jacobson, P., and Tretyakova, N.Y. (2010) Quantitative high-performance liquid chromatography-electrospray ionization tandem mass spectrometry analysis of bis-N7-guanine DNA-DNA cross-links in white blood cells of cancer patients receiving cyclophosphamide therapy. Anal. Chem. 82, 3650-8. PubMed
Goggin, M., Seneviratne, U., Swenberg, J.A., Walker, V.E., and Tretyakova, N.Y. (2010) Column switching HPLC-ESI+-MS/MS methods for quantitative analysis of exocyclic dA adducts in the DNA of laboratory animals exposed to 1,3-butadiene. Chem. Res. Toxicol. 23, 808-12. PubMed
2009
Moser, A., Guza, R., Tretyakova, N.Y., and York, D.M. (2009) Density functional study of the influence of C5 cytosine substitution in base pairs with guanine. Theor. Chem. Acc. 122, 179-188. PubMed
Loeber, R.L., Michaelson-Richie, E.D., Codreanu, S.G., Liebler, D.C., Campbell, C.R., and Tretyakova, N.Y. (2009) Proteomic analysis of DNA-protein cross-linking by antitumor nitrogen mustards. Chem. Res. Toxicol. 22, 1151-62. PubMed
Guza, R., Ma, L., Fang, Q., Pegg, A.E., and Tretyakova, N.Y. (2009) Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides. J. Biol. Chem. 284, 22601-10. PubMed
Goggin, M., Swenberg, J.A., Walker, V.E., and Tretyakova, N.Y. (2009) Molecular dosimetry of 1,2,3,4-diepoxybutane-induced DNA-DNA cross-links in B6C3F1 mice and F344 rats exposed to 1,3-butadiene by inhalation. Cancer Res. 69, 2479-86. PubMed
2008
Tretyakova, N.Y., Guza, R., and Matter, B. (2008) Endogenous cytosine methylation and the formation of carcinogen carcinogen-DNA adducts. Nucleic Acids Symp Ser (Oxf). 49-50. PubMed
Loeber, R., Michaelson, E., Fang, Q., Campbell, C., Pegg, A.E., and Tretyakova, N.Y. (2008) Cross-linking of the DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards. Chem. Res. Toxicol. 21, 787-95. PubMed
Goggin, M., Anderson, C., Park, S., Swenberg, J., Walker, V., and Tretyakova, N.Y. (2008) Quantitative high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry analysis of the adenine-guanine cross-links of 1,2,3,4-diepoxybutane in tissues of butadiene-exposed B6C3F1 mice. Chem. Res. Toxicol. 21, 1163-70. PubMed
2007
Tretyakova, N.Y., Livshits, A., Park, S., Bisht, B., and Goggin, M. (2007) Structural elucidation of a novel DNA-DNA cross-link of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol. 20, 284-9. PubMed
Quirk-Dorr, D., Murphy, K., and Tretyakova, N.Y. (2007) Synthesis of DNA oligodeoxynucleotides containing structurally defined N6-(2-hydroxy-3-buten-1-yl)-adenine adducts of 3,4-epoxy-1-butene. Chem Biol Interact. 166, 104-11. PubMed
Miksa, B., Chinnappan, R., Dang, N.C., Reppert, M., Matter, B., Tretyakova, N.Y., Grubor, N.M., and Jankowiak, R. (2007) Spectral differentiation and immunoaffinity capillary electrophoresis separation of enantiomeric benzo(a)pyrene diol epoxide-derived DNA adducts. Chem. Res. Toxicol. 20, 1192-9. PubMed
Matter, B., Guza, R., Zhao, J., Li, Z.Z., Jones, R., and Tretyakova, N.Y. (2007) Sequence distribution of acetaldehyde-derived N2-ethyl-dG adducts along duplex DNA. Chem. Res. Toxicol. 20, 1379-87. PubMed
Kim, M.Y., Tretyakova, N.Y., and Wogan, G.N. (2007) Mutagenesis of the supF gene by stereoisomers of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol. 20, 790-7. PubMed
Goggin, M., Loeber, R., Park, S., Walker, V., Wickliffe, J., and Tretyakova, N.Y. (2007) HPLC-ESI+-MS/MS analysis of N7-guanine-N7-guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene. Chem. Res. Toxicol. 20, 839-47. PubMed
Antsypovich, S., Quirk-Dorr, D., Pitts, C., and Tretyakova, N.Y. (2007) Site specific N6-(2-hydroxy-3,4-epoxybut-1-yl)adenine oligodeoxynucleotide adducts of 1,2,3,4-diepoxybutane: synthesis and stability at physiological pH. Chem. Res. Toxicol. 20, 641-9. PubMed
2006
Millard, J.T., Hanly, T.C., Murphy, K., and Tretyakova, N.Y. (2006) The 5'-GNC site for DNA interstrand cross-linking is conserved for diepoxybutane stereoisomers. Chem. Res. Toxicol. 19, 16-9. PubMed
Matter, B., Malejka-Giganti, D., Csallany, A.S., and Tretyakova, N.Y. (2006) Quantitative analysis of the oxidative DNA lesion, 2,2-diamino-4-(2-deoxy-ß-D-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), in vitro and in vivo by isotope dilution-capillary HPLC-ESI-MS/MS. Nucleic Acids Res. 34, 5449-60. PubMed
Loeber, R., Rajesh, M., Fang, Q., Pegg, A.E., and Tretyakova, N.Y. (2006) Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol. 19, 645-54. PubMed
Guza, R., Rajesh, M., Fang, Q., Pegg, A.E., and Tretyakova, N.Y. (2006) Kinetics of O6-methyl-2'-deoxyguanosine repair by O6-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences. Chem. Res. Toxicol. 19, 531-8. PubMed
2005
Rajesh, M., Wang, G., Jones, R., and Tretyakova, N.Y. (2005) Stable isotope labeling-mass spectrometry analysis of methyl- and pyridyloxobutyl-guanine adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53-derived DNA sequences. Biochemistry. 44, 2197-207. PubMed
Park, S., Anderson, C., Loeber, R., Seetharaman, M., Jones, R., and Tretyakova, N.Y. (2005) Interstrand and intrastrand DNA-DNA cross-linking by 1,2,3,4-diepoxybutane: role of stereochemistry. J. Am. Chem. Soc. 127, 14355-65. PubMed
Kim, J., Park, S., Tretyakova, N.Y., and Wagner, C.R. (2005) A method for quantitating the intracellular metabolism of AZT amino acid phosphoramidate pronucleotides by capillary high-performance liquid chromatography-electrospray ionization mass spectrometry. Mol. Pharm. 2, 233-41. PubMed
2004
Ziegel, R., Shallop, A., Upadhyaya, P., Jones, R., and Tretyakova, N.Y. (2004) Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Biochemistry. 43, 540-9. PubMed
Thomson, N.M., Mijal, R.S., Ziegel, R., Fleischer, N.L., Pegg, A.E., Tretyakova, N.Y., and Peterson, L.A. (2004) Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine. Chem. Res. Toxicol. 17, 1600-6. PubMed
Park, S., and Tretyakova, N.Y. (2004) Structural characterization of the major DNA-DNA cross-link of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol. 17, 129-36. PubMed
Park, S., Hodge, J., Anderson, C., and Tretyakova, N.Y. (2004) Guanine-adenine DNA cross-linking by 1,2,3,4-diepoxybutane: potential basis for biological activity. Chem. Res. Toxicol. 17, 1638-51. PubMed
Matter, B., Wang, G., Jones, R., and Tretyakova, N.Y. (2004) Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences. Chem. Res. Toxicol. 17, 731-41. PubMed
Balcome, S., Park, S., Quirk-Dorr, D., Hafner, L., Phillips, L., and Tretyakova, N.Y. (2004) Adenine-containing DNA-DNA cross-links of antitumor nitrogen mustards. Chem. Res. Toxicol. 17, 950-62. PubMed
2003
Ziegel, R., Shallop, A., Jones, R., and Tretyakova, N.Y. (2003) K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts. Chem. Res. Toxicol. 16, 541-50. PubMed
Upadhyaya, P., Sturla, S.J., Tretyakova, N.Y., Ziegel, R., Villalta, P.W., Wang, M., and Hecht, S.S. (2003) Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA. Chem. Res. Toxicol. 16, 180-90. PubMed
Park, S., Seetharaman, M., Ogdie, A., Ferguson, D., and Tretyakova, N.Y. (2003) 3'-Exonuclease resistance of DNA oligodeoxynucleotides containing O6-[4-oxo-4-(3-pyridyl)butyl]guanine. Nucleic Acids Res. 31, 1984-94. PubMed
2002
Tretyakova, N.Y., Matter, B., Jones, R., and Shallop, A. (2002) Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach. Biochemistry. 41, 9535-44. PubMed
Pfeifer, G.P., Denissenko, M.F., Olivier, M., Tretyakova, N.Y., Hecht, S.S., and Hainaut, P. (2002) Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene. 21, 7435-51. PubMed
2001
Tretyakova, N.Y., Matter, B., Ogdie, A., Wishnok, J.S., and Tannenbaum, S.R. (2001) Locating nucleobase lesions within DNA sequences by MALDI-TOF mass spectral analysis of exonuclease ladders. Chem. Res. Toxicol. 14, 1058-70. PubMed
2000 and Earlier
2000
Vatsadze, S.Z., Lebedev, A.T., Zyk, N.V., Zefirov, N.S., Tretyakova, N.Y., and Hass, J.R. (2000) Fragmentation of 3,7-dialkyl-1,5-diphenyl-3,7-diazabicyclo[3.3. 1]nonan-9-ones under electron ionization. Rapid Commun. Mass Spectrom. 14, 1949-53. PubMed
Tretyakova, N.Y., Wishnok, J.S., and Tannenbaum, S.R. (2000) Peroxynitrite-induced secondary oxidative lesions at guanine nucleobases: chemical stability and recognition by the Fpg DNA repair enzyme. Chem. Res. Toxicol. 13, 658-64. PubMed
Tretyakova, N.Y., Burney, S., Pamir, B., Wishnok, J.S., Dedon, P.C., Wogan, G.N., and Tannenbaum, S.R. (2000) Peroxynitrite-induced DNA damage in the supF gene: correlation with the mutational spectrum. Mutat. Res. 447, 287-303. PubMed
Swenberg, J.A., Ham, A., Koc, H., Morinello, E., Ranasinghe, A., Tretyakova, N.Y., Upton, P.B., and Wu, K. (2000) DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene. Mutat. Res. 464, 77-86. PubMed
1999
Tretyakova, N.Y., Niles, J.C., Burney, S., Wishnok, J.S., and Tannenbaum, S.R. (1999) Peroxynitrite-induced reactions of synthetic oligonucleotides containing 8-oxoguanine. Chem. Res. Toxicol. 12, 459-66. PubMed
Koc, H., Tretyakova, N.Y., Walker, V.E., Henderson, R.F., and Swenberg, J.A. (1999) Molecular dosimetry of N-7 guanine adduct formation in mice and rats exposed to 1,3-butadiene. Chem. Res. Toxicol. 12, 566-74. PubMed
1998
Tretyakova, N.Y., Chiang, S.Y., Walker, V.E., and Swenberg, J.A. (1998) Quantitative analysis of 1,3-butadiene-induced DNA adducts in vivo and in vitro using liquid chromatography electrospray ionization tandem mass spectrometry. J. Mass Spectrom. 33, 363-76. PubMed
1997
Tretyakova, N.Y., Sangaiah, R., Yen, T.Y., and Swenberg, J.A. (1997) Synthesis, characterization, and in vitro quantitation of N-7-guanine adducts of diepoxybutane. Chem. Res. Toxicol. 10, 779-85. PubMed
Tretyakova, N.Y., Sangaiah, R., Yen, T.Y., Gold, A., and Swenberg, J.A. (1997) Adenine adducts with diepoxybutane: isolation and analysis in exposed calf thymus DNA. Chem. Res. Toxicol. 10, 1171-9. PubMed
Tretyakova, N.Y., Lin, Y., Sangaiah, R., Upton, P.B., and Swenberg, J.A. (1997) Identification and quantitation of DNA adducts from calf thymus DNA exposed to 3,4-epoxy-1-butene. Carcinogenesis. 18, 137-47. PubMed
Tretyakova, N.Y., Hass, J.R., Saginova, L.G., and Lebedev, A.T. (1997) Decomposition of 3,5-diaryloxathiolane-2-oxides under electron impact. Int. J. Mass Spectrom. Ion Processes. 165-166, 611-623. PubMed
Sangaiah, R., Christova-Gueorguieva, N.I., Ranasinghe, A., Tretyakova, N.Y., Gold, A., Ball, L.M., and Swenberg, J.A. (1997) Synthesis of perdeuterated analogues of the epoxide metabolites of butadiene: 1,2-epoxybut-3-ene-d6 and 1,2,3,4-diepoxybutane-d6. J. Labelled Compd. Radiopharm. 39, 731-739. PubMed
Lebedev, A.T., Samguina, T.Y., Predein, E.V., Bakoulev, V.A., Tretyakova, N., and Hass, J.R. (1997) Isomerization of thioamidomethyl pyridine ylides and isoquinoline ylides under electron impact. Eur. J. Mass Spectrom. 3, 217-223. PubMed
Lebedev, A.T., Karakhanova, N.K., Sipyaguin, A.M., Efremov, I.V., Tretyakova, N.Y., and Hass, R. (1997) Comparative study of the cyclization of dithiocarbamate derivatives of polyhalopyridines induced by electron impact and carried out in solution. J. Mass Spectrom. 32, 728–738. PubMed
1996 and earlier
Tretyakova, N.Y., Lin, Y.P., Upton, P.B., Sangaiah, R., and Swenberg, J.A. (1996) Macromolecular adducts of butadiene. Toxicology. 113, 70-6. PubMed
Tretyakova, N.Y., Lebedev, A.T., and Petrosyan, V.S. (1994) Degradative pathways for aqueous chlorination of orcinol. Environ. Sci. Technol. 28, 606-13. PubMed