Wang, Y., Chaffee, T., LaRue, R.S., Huggins, D.N., Witschen, P.M., Ibrahim, A.R., Nelson, A.C., Machado, H.L., Schwertfeger, K.L. Tissue resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice. eLife 2020;9:e57438 DOI: 10.7554/eLife.57438
Witschen, P.M.; Chaffee, T.S.; Brady, N.J.; Huggins, D.N.; Knutson, T.P.; LaRue, R.S.; Munro, S.A.; Tiegs, L.; McCarthy, J.B.; Nelson, A.C.; Schwertfeger, K.L. Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer. Cancers 2020, 12, 1325.
Irey, E.A., Lassiter, C.M., Brady, N.J., Chuntova, P., Wang, Y., Knutson, T.P., Henzler, C., Chaffee, T., Vogel, R.I., Nelson, A.C., Farrar, M.A. and Schwertfeger, K.L. JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of pro-tumorigenic factors. PNAS. 116(25): 12442-12451. PMID 31147469.
Brian, B.F. IV, Ewan, E., Nunez, M.G., Schwertfeger, K.L. and Freedman, T.S. Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells. Elife. 8, pii: e46043. PMID 31282857.
Nelson AC, Machado HL, Schwertfeger KL. Breaking through to the other side: Microenvironment contributions to DCIS initiation and progression. J Mammary Gland Biol Neoplasia. 2018 Aug 31. doi: 10.1007/s10911-018-9409-z.
Doak, G., Schwertfeger, K.L.* and Wood, D.K.* Distant relations: macrophage functions in the metastatic niche. Trends in Cancer. 4(6): 445-459, 2018. PMID 29860988.
Regan Anderson, T.M., Ma, S., Perez Kerkvliet, C., Peng, Y., Helle, T.M., Krutilina, R.I., Raj, G.V., Cidlowski, J.A., Ostrander, J.H., Schwertfeger, K.L., Seagroves, T.N. and Lange, C.A. Taxol induces Brk-dependent prosurvival phenotypes in TNBC cells through an AhR/GR/HIF-driven signaling axis. Molecular Cancer Research, 16(11): 1761-1772, 2018. PMID 29991529.
Truong, T.H., Hu, H., Temiz, N.A., Hagen, K., Girard, B.J., Brady, N.J., Schwertfeger, K.L., Lange, C.A. and Ostrander, J.H. Cancer stem cell phenotypes in ER+ breast cancer models are promoted by PELP1/AIB1 complexes. Molecular Cancer Research. 16(4): 707-719, 2018 PMID 29348189.
Aukes, K., Forsman, C., Brady, N.J., Astleford, K., Blixt, N., Sachdev, D., Jensen, E.D., Mansky, K.C.* and Schwertfeger, K.L.* Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions. PLoS One, 12(10):e0185736, 2018. PMID 28968431.
Brady, N.J., Farrar, M.A. and Schwertfeger, K.L. STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development. Developmental Biology. 428(1), 232-244, 2017. PMID 28606561.
Knutson, T.P., Truong, T.H., Brady, N.J., Sullivan, M.E., Ma, S.H., Raj, G., Schwertfeger, K.L. and Lange, C.A. Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs. Journal of Hematology and Oncology. 10(1), article 89, 2017.
Girard, B.J., Knutson, T.P., Kuker, B., McDowell, L., Schwertfeger, K.L. and Ostrander, J.H. Cytoplasmic localization of proline, glutamic acid, leucine-rich protein 1 (PELP1) induces breast cancer cell migration through up-regulation of inhibitor of kB kinase e and inflammatory cross-talk with macrophages. Journal of Biological Chemistry, 292(1), 339-350, 2017. PMID 27881676, PMCID 5217682.
Bohrer, L.R., Chaffee, T.S., Chuntova, P., Brady, N.J., Witschen, P.M., Kemp, S.E., Nelson, A.C., Walcheck, B. and Schwertfeger, K.L. ADAM17 in tumor associated leukocytes regulates inflammatory mediators and promotes mammary tumor formation. Genes and Cancer. 7(7-8), 240-253, 2016. PMID 27738494, PMCID 5059114.
Brady, N.J., Chuntova, P., Schwertfeger, K.L. Macrophages: regulators of the inflammatory microenvironment during mammary gland development and breast cancer. Mediators of Inflammation. Vol. 2016, Article ID 4549676, 2016. PMID: in process. PMCID: in process.
Brincks, E.L., Kucaba, T.A., James, B.R., Murphy, K.A., Schwertfeger, K.L., Sangwan, V., Banerjee, S., Saluja, A.K. and Griffith, T.S. Triptolide enhances the tumoricidal activity of TRAIL against renal cell carcinoma. FEBS J. 282(24), 4747-4765, 2015. PMID 26426449, PMCID 4715782.
Farooqui, M., Bohrer, L.R., Brady, N.J., Chuntova, P., Kemp, S.E., Wardwell, C.T., Nelson, A.C. and Schwertfeger, K.L. Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival. Molecular Cancer. 14(138), 2015. PMID: 26215578.
Schwertfeger, K.L., Cowman, M.K., Telmer, P.G., Turley E.A. and McCarthy, J.M. Hyaluronan, inflammation and breast cancer progression. Frontiers in Immunology. 8(6), 2015. PMID 26106384
Cowman, M.K., Lee, H.G., Schwertfeger, K.L., McCarthy, J.B. and Turley, E.A. The content and size of hyaluronan in biological fluids and tissues. Frontiers in Immunology. 2(6), 2015. PMID 26082778
Adulov, S., Herrera, J., Smith, K., Peterson, M., Gomez-Garcia, J.R., Beadnell, T.C., Schwertfeger, K.L., Benyumov, A.O., Manivel , J.C., Li, S., Bielinsky, A.K., Yee, D., Bitterman, P.B. and Polunovsky, V.A. eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells. Cancer Research. 75(4), 687-697, 2015. PMID 25524901, PMCID 4333007.
Tseng, Y.Y., Moriarity, B.S., Gong, W., Akiyama, R., Tiwari, A., Kawakami, H., Ronning, P., Reuland, B., Guenther, K., Beadnell, T.C., Essig, J., Otto, G.M., O’Sullivan, M.G., Largaespada, D.A., Schwertfeger, K.L.*, Marahrens, Y. *, Kawakami, Y. * and Bagchi, A. Pvt1-dependence in cancer with MYC copy-number-increase. Nature, 512(7512): 82-86, 2014. PMID: 25043044
Klos, K.S., Warmka, J.K., Drachenberg, D.M., Chang, L., Luxton, G., Leung, C.T., Schwertfeger, K.L. and Wattenberg, E.A. Building Bridges Toward Invasion: Tumor Promoter Treatment Induces a Novel Protein Kinase C-Dependent Phenotype in MCF10A Mammary Cell Acini. Plos One 9(3), e90722, 2014. PMID: 24599099
Bohrer, L.R.*, Chuntova, P.*, Bade, L.K., Beadnell, T.C., Leon, R.P., Brady, N.J., Ryu, Y., Goldberg, J.E., Koopmeiners, J.S., McCarthy, J.B. and Schwertfeger, K.L. Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation. Cancer Research, 74(1): 374-386, 2014. PMID:24197137
Forsman, C.L., Ng, B.C., Heinze, R.K., Kuo, C., Gopalakrishnan, R., Yee, D., Graf, D., Schwertfeger, K.L. and Petryk, A. BMP-binding protein Twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization. Developmental Biology. 373(1), 95-106, 2013. PMID 23103586.
Brady, N.J. *, Chuntova, P. *, Bade, L.K. and Schwertfeger, K.L. The FGF/FGFR axis in breast cancer. Expert Reviews in Endocrinology and Metabolism. 8(4), 391-402, 2013.
Bohrer, L.R. and Schwertfeger, K.L. Macrophages promote fibroblast growth factor receptor-driven tumor cell migration and invasion in a Cxcr2-dependent manner. Molecular Cancer Research. 10(10), 1294-1305, 2012. PMID 22893608.
Reed, J.R., Stone, M.D., Beadnell, T.C., Ryu, Y., Griffin, T.J. and Schwertfeger, K.L. Fibroblast growth factor receptor 1 activation in mammary tumor cells promotes macrophage recruitment in a CX3CL1-dependent manner. PLoS ONE. 7(9):e45877, 2012. PMID 23029290.
Lofgren, K.A., Housa, D., Hubbard, G.K., Schwertfeger, K.L. and Lange, C.A. Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK. Breast Cancer Research. 13(5), R89, 2011. PMID: 21923922
Bade, L. K., Goldberg, J.E., DeHut, H.A., Hall, M.K. and Schwertfeger, K.L. Mammary tumorigenesis induced by fibroblast growth factor receptor-1 requires activation of the epidermal growth factor receptor. Journal of Cell Science. 124(18), 3106-3117, 2011. PMID: 21868365
Pond, A., Herschkowitz, J., Schwertfeger, K.L., Welm, B., Zhang, Y., York, B., Cardiff, R., Hilsenbeck, S., Perou, C., Creighton, C., Lloyd, R. and Rosen, J. FGF Receptor signaling dramatically accelerates tumorigenesis and oncoprotein translation in the MMTV-Wnt1 mouse model of breast cancer. Cancer Research. 70(12), 4868-4879, 2010. PMID: 20501844.
Reed, J.R. and Schwertfeger, K.L. Immune cell location and function during post-natal mammary gland development. Journal of Mammary Gland Biology and Neoplasia. 15(3), 329-339, 2010. PMID 20730636.
Dressing, G.E., Goldberg, J.E., Charles, N.J., Schwertfeger, K.L. and Lange, C.A. Membrane progesterone receptor expression in mammalian tissues: a review of regulation and physiological implications. Steroids. 76(1-2), 11-17, 2010. PMID 20869977.
Goldberg, J.E. and Schwertfeger, K.L. Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics. Current Drug Targets. 11(9), 1133-1146, 2010. PMID 20545607.
Reed, J.R., Leon, R.P., Hall, M.K. and Schwertfeger, K.L. Interleukin-1beta Cooperates with Fibroblast Growth Factor Receptor 1 to Promote Early Stages of Mouse Mammary Tumorigenesis. Breast Cancer Research. 11(2), R21, 2009.
Schwertfeger, K.L. Fibroblast growth factors in development and disease: insights from the mammary and prostate glands. Current Drug Targets. 10(7), 632-644, 2009.
Xian, W., Schwertfeger, K.L., and Rosen, J.M. Distinct roles of FGFR1 and FGFR2 in regulating cell survival and epithelial-mesenchymal transition. Molecular Endocrinology.21 (4), 987-1000, 2007.
Schwertfeger, K.L., Xian, W., Cohen, D.A., and Rosen, M.J. 2006. A critical role for the inflammatory response in a mouse model of preneoplastic progression. Cancer Research 66(11), 5675-5685.
Schwertfeger, K.L., Rosen, J.M., and Cohen, D.A. 2006. Mammary gland macrophages: Pleiotroppic functions in mammary development. Journal of Mammary Gland Biology and Neoplasia. 11(3-4), 229-238.
Xian, W., Schwertfeger, K.L., Vargo-Gogola, T.C., and Rosen, J.M. Pleiotropic effects of FGFR1 on cell proliferation, survival and migration in a 3D mammary epithelial cells model. Journal of Cell Biology 171(4), 663-673, 2005.
Schwertfeger, K.L., McManaman, J.L., Palmer, C.A., Neville, M.C., and Anderson, S.M. Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation. Journal of Lipid Research. 44(6), 1100-1112, 2003.
Schwertfeger, K.L., Richert, M.M., and Anderson, S.M. Mammary Gland Involution is Delayed by Activated Akt in Transgenic Mice. Molecular Endocrinology. 15(6), 867-881, 2001.
Richert, M.M.*, Schwertfeger, K.L.*, Ryder, J.W., and Anderson, S.M. An Atlas of Mouse Mammary Gland Development. Journal of Mammary Gland Biology and Neoplasia. 5(2), 227-241, 2000. *These authors contributed equally.