The Viral Innovation Core (VIC) aims to develop novel genetic approaches for the experimental study of the anatomical, cellular, and molecular bases of addiction.

The Structural Circuits Core (SCC) offers state-of-the-art anatomical mapping of neural circuits involved in addiction. Integrated with the University Imaging Centers (UIC) and UMN Informatics Institute (UMII), the SCC provides automated use of brain clearing technology paired with meso- and micro-scale imaging of the central nervous system.

The Imaging Cells during Behavior Core (ICBC) aims to provide imaging tools, computational software, and engineering expertise to neuroscience researchers investigating the brain during behavior. In addition to providing services with established tools, the ICBC also innovates new technologies to improve neural imaging capabilities.

The Addiction Connectome Core (ACC) aims to create a big data computational platform that integrates findings across many types of experimental studies to reveal the relationships between exposure to addictive drugs, brain circuits and addictive behavior.