MCC Symposium Abstracts
Poster Session #1
Genetic Mechanisms (GM)
Jennifer Boyle, BS | boyle189@umn.edu
Poster Location: Zone A, Number 1
Mentor: Rebecca Morris, PhD
Bio: I am a recent graduate from the University of Wisconsin - Eau Claire and am currently working as a Researcher 2 at the Hormel Institute, University of Minnesota. I am planning on furthering my education in the future.
Bone marrow-derived epithelial cells contribute to development of chronic cutaneous neoplasms
Authors: Heuijoon Park, Sonali Lad, Kelsey Boland, Kelly Johnson, Nyssa Readio, Guangchun Jin, Samuel Asfaha, Kelly S. Patterson, Ashok Singh, Xiangdong Yang, Douglas Londono, Anupama Singh, Carol Trempus, Jennifer Boyle, Stephanie M. Holtorf, Derek Gordon, Timothy C. Wang and Rebecca J. Morris
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Ya-Chu Chang | chan1285@umn.edu
Poster Location: Zone A, Number 2
Mentor: Anja-Katrin Bielinsky, PhD
Bio: Ya-Chu Chang is a Ph.D. candidate in the Bielinsky Laboratory. Her studies focus on the molecular mechanisms in DNA replication by integrating proteomics and large-scale CRISPR/Cas9 screening technologies.
A novel role of an old drug - Bortezomib disrupts DNA replication in cells depleted of RNF4 and USP7
Authors: Chang YC, Lin K, Baxley RM, Stojkova O, Billmann M, Ward H, Myers CL, and Bielinsky AK
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Wannasiri Chiraphapphaiboon | chira017@umn.edu
Poster Location: Zone A, Number 3
Mentor: Zohar Sachs, MD, PhD
Investigation of APR-246 effects on TP53-mutated leukemia stem cells
Authors: Chiraphapphaiboon W, Antony ML, Noble-Orcutt KE, Sachs Z
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Victor Corral | corra045@umn.edu
Poster Location: Zone A, Number 4
Mentor: Hai Dang Nguyen, PhD
Deciphering a phosphorylation circuitry of RNase H1 in R-loop homeostasis
Authors: Corral VM, Bannister M, Nguyen DH
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Stephanie Holtorf | sholtorf@umn.edu
Poster Location: Zone A, Number 5
Mentor: Dr. Rebecca Morris
Bio: I am a Researcher 3 and Lab Manager of the Stem Cells and Cancer section at the Hormel Institute, University of Minnesota. I am also a graduate student in the Bioinformatics and Computational Biology (BICB) program through UMR with Dr. Rebecca Morris as my mentor. I am passionate about social justice and getting local kids excited about science.
Epithelial cells in human and murine blood and bone marrow
Authors: Holtorf SM, Schuster T, Monts JK, Gordon D, and Morris RJ
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Taylor DePauw | depa0049@umn.edu
Poster Location: Zone A, Number 6
Mentor: Jaime F. Modiano, VMD, PhD
Bio: Taylor graduate from University of Wisconsin-Stout with a BS in Applied Science-Biotechnology. After graduating she started in Dr. Modiano's lab where she started working on the Shine On early detection test for hemangiosarcoma. In 2021 Taylor started as a graduate student in the MICaB program.
Machine Learning for Early Detection of Hemangiosarcoma
Authors: Taylor DePauw, Ali Khammanivong, Jaime F. Modiano
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Jolene Duda | duda0032@umn.edu
Poster Location: Zone A, Number 7
Mentor: Jaime F. Modiano, VMD, PhD
Bio: My ongoing pre-doctoral research is focused on applying a mass spectrometry proteomics-based approach towards elucidating epigenetic changes in ovarian cancer.
Elucidating histone deacetylase inhibitor-induced perturbations in high-grade serous ovarian cancer
Authors: Duda JM, Thomas SN
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Aditi Kulkarni | kulka126@umn.edu
Poster Location: Zone A, Number 8
Mentor: Andrew Venteicher, MD PhD
Uncovering the developmental origins of chordoma using single-nuclear RNA sequencing
Authors: Kulkarni AS, Garcia JG, Smith OC, Venteicher AS
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Yoonkyu Lee | leex5085@umn.edu
Poster Location: Zone A, Number 9
Mentor: Zohar Sachs, MD, PhD
Bio: I am a Pd.D. student in the Bioinformatics and Computational Biology (BICB) program and a member of Sachs Lab. My current research is investigating whether primary human AML stem cells express features of the murine-derived single-cell self-renewal gene expression profile and identify human AML specific transcriptional features.
Identifying self-renewing subpopulation of human leukemia stem cells using scRNAseq analysis
Authors: Lee Y, Wang W, Starr TK, Noble-Orcutt KE, Myers CL, Sachs Z
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Katherine McKenney | ande9526@umn.edu
Poster Location: Zone A, Number 10
Mentor: Aaron C. Goldstrohm, PhD and Zohar Sachs, MD, PhD
Bio: I am an American Cancer Society postdoctoral fellow studying post-transcriptional gene regulation in cancer.
Mechanisms of Translational Repression by Human Pumilio RNA Binding Proteins
Authors: McKenney KM, Serrano LR, Dao MK, Corbo JH, Mustoe AM, Coon JJ, Valkov E, Sachs Z, and Goldstrohm AC
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Ellie Mews | hofer062@umn.edu
Poster Location: Zone A, Number 11
Mentor: David Largaespada, PhD
Bio: 8 years of experience in biochemistry and immunology with a focus on protein engineering, immunotherapeutic development, and cancer & immune cell biology.
Extensive background in flow cytometry, confocal microscopy, mammalian cell culture, primary immune cell culture, live cell imaging assays, immunoassays, standard biochemical and molecular techniques, chromatography, and small animal testing.
Strong team leader with experience in managing multiple projects on collaborative teams; competent mentor for students from all backgrounds, highly disciplined and self-motivated, exceptional organization and lab management skills.
Targeting the overexpressed cancer antigen, B7-H3, with bispecific immune cell engaging biologics.
Authors: Mews EA, Nikrad JA, Sheehy M, Davis ZB, Liebau J, Kulkarni A, Wagner CR, Miller JS, Largaespada DA
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Julia Nikrad | nikr0006@umn.edu
Poster Location: Zone A, Number 12
Mentor: David Largaespada, PhD
Oncolytic Adenovirus as a Therapy for Malignant Peripheral Nerve Sheath Tumors
Authors: Nikrad JA, Galvin RT, Sheehy MM, Jacobsen KL, Novacek EL, Yamamoto M, Largaespada DA.
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Eunice Oribamise | oriba004@umn.edu
Poster Location: Zone A, Number 13
Mentor: David Largaespada, PhD
NMD inhibition is required for effective nonsense suppression in a porcine model of NF1
Authors: Oribamise EI, Osum SH, Corbière S, Taisto m, Coutts A, Kirstein M, Fisher J, Moertel C, Bedwell D, Largaespada D, Watson AL.
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Shuhei Shinoda | shino065@umn.edu
Poster Location: Zone A, Number 14
Mentor: Masato Yamamoto, MD, PhD
Oncolytic adenovirus expressing IFN-alpha with chemoradiation inhibits pancreatic cancer cell growth
Authors: Shinoda S, Nakamura N, Sato-Dahlman M, Inoko K, Davydova J, Yamamoto M
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Dechen Wangmo | wangm005@umn.edu
Poster Location: Zone B, Number 15
Mentor: Subree Subramanian, PhD
Role of tumor-cell intrinsic factors in colorectal cancer immune evasion
Authors: Dechen W
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Yunong Xia | xia00045@umn.edu
Poster Location: Zone B, Number 16
Mentor: Ruping Sun, PhD
Bio: Yunong Xia BA, 2021, University of Minnesota, is currently working with Dr. Ruping Sun and studying cancer genomics evolutionary dynamics.
Charting copy number phylogeny from mutational divergence
Authors: Yunong Xia, Ruping Sun
Immunology (IMM)
Khadar Abdi | abdik@umn.edu
Poster Location: Zone B, Number 17
Mentor: Yoji Shimizu, PhD
Impact of extended ex vivo expansion on tissue residency after adoptively transferring CD8+ T cells.
Authors: Abdi K, Burbach B., Shimizu Y
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Noah Gavil | gavil014@umn.edu
Poster Location: Zone B, Number 18
Mentor: David Masopust, PhD
Bio: Noah grew up in Bethesda, Maryland before completing his bachelor's degree in Maine at Bowdoin College. He then went to the NIH as a postbaccalaureate fellow, researching T cell-mediated mechanisms of HIV control. In 2016, Noah matriculated into the UMN MSTP and is now completing his dissertation work in the lab of David Masopust, PhD.
Tumor antigen recognition drives a distinct program of T cell residence in solid tumor
Authors: Gavil NG, Scott MC, Weyu E, Smith O, Wijeyesinghe SP, Masopust D
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J.T. Greene | gree0819@umn.edu
Poster Location: Zone B, Number 19
Mentor: Tanya Freedman, PhD
Bio: I started my career at the Masonic Cancer Center studying CAR-T therapy. During graduate school at Ohio State University, I studied the function of the tumor suppressor Par-4 in chronic lymphocytic leukemia. I am now starting my third year as a postdoc in Dr. Tanya Freedman's lab studying tumor immunology and the role of Lyn kinase in the function of intertumoral myeloid cells.
Lyn Kinase in the Tumor-Associated Myeloid Cells
Authors: Greene JT, Brian BF, Nunez MG, Freedman TS
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Lynn Heltemes Harris | harr0905@umn.edu
Poster Location: Zone B, Number 20
Mentor: Michael Farrar
The Role of Truncated SOS1 in Acute Lymphoblastic Leukemia
Authors: Lynn M. Heltemes-Harris, Grey Hubbard, Rebecca S. LaRue, Sarah Munro, Michael A. Farrar
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Jacob Myers
Poster Location: Zone B, Number 21
Mentor: Jeffrey Miller, MD
Balanced engagement of activating and inhibitory receptors mitigates human NK cell exhaustion
Authors: Myers JM, Schirm D, Felices M, Miller JS
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Jacob Myers
Poster Location: Zone B, Number 22
Mentor: Jeffrey Miller, MD
Exploring Mechanisms of Activating Receptor-Induced Exhaustion in Human NK Cells
Authors: Myers JA, Schirm D, Bendzick L, Hopps R, Hinderlie P, Felices M, Miller JS
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Monica Sauer | sauer279@umn.edu
Poster Location: Zone B, Number 23
Mentor: Tanya Freedman, PhD
Bio: I am a second-year student in the Biochemistry, Molecular Biology, & Biophysics PhD program at the University of Minnesota. I am currently studying immune cell signaling in lupus and cancer in Dr. Tanya Freedman's lab.
Sex-specific differences in LynA and LynB signaling
Authors: Sauer ML, Freedman TS
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Hrishi Venkatesh (Presented by Sean Tracy) | venka201@umn.edu
Poster Location: Zone B, Number 24
Mentor: Dr. Michael Farrar, PhD
Bio: 3rd year graduate student in the Microbiology, Immunology and Cancer Biology (MICaB) Graduate Program
Checkpoint blockade-based therapy elicits a CD4 T cell-dependent protection against b cell leukemia
Authors: Venkatesh H, Tracy S, Hekim C, Knutson T, Farrar MA.
Screening, Prevention, Etiology, and Cancer Survivorship (SPECS)
Kevin Agostinucci | agost031@umn.edu
Poster Location: Zone B, Number 25
Mentor: Beshay Zordoky, PhD
Bio: My research interests are to understand the underlying mechanisms that bring out cardiovascular disease and to identify therapeutic targets to treat these diseases. I have spent my graduate school training studying cardiovascular pharmacology and physiology. The goal of my postdoctoral work is to identify the mechanisms in which hypertension, and other cardiovascular insults, exacerbates the subclinical cardiotoxicity induced by juvenile exposure to doxorubicin.
Exposure to Doxorubicin Modulates the Cardiac Response to Isoproterenol in a Sex-Dependent Manner
Authors: Agostinucci K, Grant MKO, Melaku W, Abdelgawad IY, Zordoky BN
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Renata Braudy | rbraudy@umn.edu
Poster Location: Zone B, Number 26
Mentor: Linda Koehler, PT, PhD
Bio: Renata is a physical therapist with 20 years of clinical experience, with 16 years specializing in oncology rehabilitation. She is a PhD Candidate under Dr. Linda Koehler and Dr. Paula Ludewig in the Rehabilitation Science Graduate Program. She also works as a Research Assistant for Dr. Koehler and a clinical Physical Therapist with UMP/M Health Fairview assisting with the growth of a Breast Cancer Rehabilitation/Wellness Physical Therapy Program.
Shoulder Kinematics of Axillary Web Syndrome in Women Treated for Breast Cancer
Authors: Braudy RA, Atoms B, Coghlan J, Howell M, Moga D, Tollefsrud M, Lawrence R, Ludewig P, Koehler LA
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Himal Purani | puran006@umn.edu
Poster Location: Zone B, Number 28
Mentor: Anne Blaes, MD, MS
Bio: Himal Purani is a rising 4th year medical student at the University of Minnesota Medical School. She is interested in the field of oncology and would like to advocate for that patient population in the future given her experiences inside and outside of medicine. She is particularly interested in the field of cancer survivorship and has spent some time investigating the financial burden of cancer care on cancer survivors and their families.
Vulnerability for Financial Toxicity Among Cancer Survivors with Underage Children
Authors: Purani H; Jewett P; Vogel, R; Gu, C; Blaes, A
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Madison Kolbow | kolbo010@umn.edu
Poster Location: Zone B, Number 29
Mentor: Jane Hui, MD MS FRCSC FACS
Bio: Madison Kolbow is a first-year medical student at the University of Minnesota.
Chemotherapy refusal and survival in older women with high genomic risk ER-positive breast cancer
Authors: White MJ, Prathibha S, Kolbow M, Praska C, Ankeny J, LaRocca CJ, Jensen EH, Tuttle TM, Marmor S, Hui JYC
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Kate Weis | weis0768@umn.edu
Poster Location: Zone B, Number 30
Mentor: David Haynes, PhD
Bio: Kate Weis is a second-year master's student in the Public Health Administration and Policy division of the School of Public Health at the University of Minnesota. Additionally, Kate works as a Graduate Research Assistant at the University of Minnesota Institute for Health Informatics under the direction of Dr. David Haynes.
Arming iPSC-derived NK cells Expressing a Novel CD64 Fusion Receptor to Target B Cell Lymphoma
Authors: Dixon KJ, Khaw M, Snyder KM, Hullsiek R, Matson AW, Davis Z, Lee T, Chu H, Abujarour R, Dinella J, Bjordahl B, Hancock B, Shirinbak S, Miller JS, Valamehr B, Wu J, Walcheck B
Transplantation and Cellular Therapy (TCT)
Erin Wesley | wesle091@umn.edu
Poster Location: Zone C, Number 31
Mentor: Melissa Geller, MD
Bio: Dr. Erin Wesley is a Post-doctoral Associate in Dr. Melissa Geller’s lab in the department of Obstetrics, Gynecology and Women’s health. Her overall research goals are improving ovarian cancer outcomes. Her research focuses on understanding the role of cytomegalovirus infection and inflammation on the immune system and how it influences the adaptive NK cell response in ovarian cancer.
The impact of CMV seropositivity and inflammation on the immune repertoire in ovarian cancer
Authors: Wesley E, Felices M, Uppendahl L, Messelt A, Vogel RI, Nelson H, Geller MA
Cellular Mechanisms (CM)
Sk. Kayum Alam | skalam@umn.edu
Poster Location: Zone C, Number 32
Mentor: Luke Hoeppner, PhD
Bio: As a scientist at the Hormel institute, I apply my knowledge to initiate, develop, and answer critical scientific questions that advances current knowledge in the lung cancer field and contribute to the development of new treatment strategies for lung cancer, with an emphasis on preventing drug resistance.
IKKα interacts with DARPP-32 to promote lung adenocarcinoma growth
Authors: Alam SK, Wang L, Zhu Z, Hoeppner LH
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Aditi Bapat | bapat019@umn.edu
Poster Location: Zone C, Number 33
Mentor: Kaylee Schwertfeger, PhD
Bio: I am a fourth year PhD candidate in the Molecular Pharmacology and Therapeutics Graduate program studying tumor-stromal cell interactions in triple negative breast cancer. I study signaling pathways activated by inhibitors of oncogenic signaling in tumor-associated macrophages.
Contributions of NF-κB in tumor-associated macrophages promoting resistance to JAK inhibition
Authors: Bapat AS, O'Connor C, Schwertfeger KL
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Betsy Benner | benne596@umn.edu
Poster Location: Zone C, Number 34
Mentor: Julie Ostrander, PhD
Inducible Expression of Cytoplasmic PELP1 Promotes ER+ Breast Cancer Invasion
Authors: Benner EA, Colon Ortiz AN, Truong TH, Hagen KM, Lange CA, Ostrander JH
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Jingran Cao | cao00072@umn.edu
Poster Location: Zone C, Number 35
Mentor: Douglas Yee, MD
Bio: I am a Ph.D. candidate in Pharmacology, my research focuses on breast cancer.
Targeting insulin receptor in estrogen receptor positive breast cancer
Authors: Jingran C, Lynsey MF, Xihong Z, Kelly L, Sylaja M, Andrea RD, Thomas ML, Todd CZ and Douglas Y.
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Alexis Elfstrum | elfst022@umn.edu
Poster Location: Zone C, Number 36
Mentor: Kaylee Schwertfeger, PhD
Bio: I am a 3rd year MICaB graduate student in Dr. Kaylee Schwertfeger's lab.
LYVE-1+ macrophages fragment hyaluronan, promoting mammary gland homeostasis and tumor progression
Authors: Elfstrum AK, Schwertfeger KL
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Mark Daniel | dani0356@umn.edu
Poster Location: Zone C, Number 37
Mentor: Scott Dehm, PhD
Bio: Mark Daniel is an 8th year graduate student in the Dehm Lab.
Comparative analysis of AR gene rearrangements in circulating tumor cells and cell-free DNA
Authors: Daniel ML, Knutson TP, Sperger JM, Li Y, Singh A, Stahlfeld CN, Passow C, Auch B, Lang JM, Dehm SM
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Nikita Kamath | kamat091@umn.edu
Poster Location: Zone C, Number 39
Mentor: Dr. Julie Ostrander, PhD
Modulating PELP1 localization in ER-Positive Breast Cancer
Authors: Kamath NG, Benner EA, Ostrander JH
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Jianxun Lei | leixx007@umn.edu
Poster Location: Zone C, Number 40
Mentor: David Potter, MD PhD
(±) 14,15-EET Induces Hallmark ER and MYC Gene Expression in ER+/HER2- Breast Cancer Cells
Authors: Lei J, Guo Z, Molina-Vega J, Cervantes P, Jayaraman S, Hawse JR, Perez C, Abrahante J, Tang X, Kalari K, Wang J, Falck JR, Lange C, Goetz MP, and Potter DA
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Brandi McKnight | mckni070@umn.edu
Poster Location: Zone C, Number 41
Mentor: Carston Rick Wagner
Bio: My name is Brandi McKnight, and I'm a graduate student in the Wagner lab. My research focuses on the use of chemically self-assembled nanostructures to facilitate cell to cell interactions.
Avidity Modulation of Bispecific Chemically Self-Assembled Nanorings (CSANs)
Authors: McKnight B, Kilic O, Wagner C
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Seth Richard | rich1107@umn.edu
Poster Location: Zone C, Number 42
Mentor: Sergio A Gradilone, PhD
Ciliary Defects Induces Sustained Epidermal Growth Factor Receptors Signaling in cholangiocarcinoma
Authors: Kishor Pant, Seth Richard, Subheksha baral, Tetyana Masyuk, Anatoliy Masuy, Nicholas F. LaRusso, and Sergio A. Gradilone
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Thu Truong
Poster Location: Zone C, Number 43
Mentor: Carol Lange, PhD
Steroid receptor co-activator complexes regulate PFKFBs to drive therapy resistant ER+ breast cancer
Authors: Truong TH, Benner B, Hagen KM, Temiz NA, Ostrander JH, Lange CA
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Li Wang | wang8752@umn.edu
Poster Location: Zone C, Number 44
Mentor: Luke Hoeppner, PhD
Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
Authors: Wang L, Astone M, Alam SK, Zhu Z, Pei WH, Frank DA, Burgess SM, Hoeppner LH
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Xianghu Wang | wang9399@umn.edu
Poster Location: Zone C, Number 45
Mentor: Ningling Kang, PhD
TGFbeta-induced glycolysis in hepatic stellate cells is facilitated by a PKCzeta/VASP signaling axis
Authors: Xianghu W, Yuanguo W, Ningling K
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Yuanguo Wang | wang7968@umn.edu
Poster Location: Zone C, Number 46
Mentor: Ningling Kang, PhD
Glycolysis and myofibroblastic activation of hepatic stellate cells is mediated by Src SH3 domain
Authors: Yuanguo W, Xianghu W, Aurpita S, Ningling K
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Joshua Fry | fryxx094@umn.edu
Poster Location: Zone C, Number 47
Mentor: Rendong Yang
Bio: I am currently a first-year master's student in Bioinformatics and Computational Biology. I work in the Yang Lab for computational cancer genomics at the Hormel Institute in Austin, Minnesota.
A pan-cancer transcriptome analysis of 3'UTR exitron splicing
Authors: Fry J, Yang R
Carcinogenesis and Chemoprevention (CC)
Andrew Floeder | floed013@umn.edu
Poster Location: Zone C, Number 49
Mentor: Silvia Balbo, PhD
Bio: I am a third year PhD student at the University of Minnesota School of Public Health in the Division of Environmental Health Sciences studying Occupational and Environmental Epidemiology. My research focuses on understanding the role of complex exposures that lead to adverse health effects. Using mass spectrometry, I have developed new analytical methods to identify and quantify environmental and occupational exposures as well as investigate how they may result in an increased risk of potential adverse outcomes.
LC-MS/MS surface sampling method development of chemotherapy contamination in occupational settings
Authors: Floeder A., Huang J., Jeronimo M., Villalta P.W., Borgatti A., Arnold S., Balbo S.
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Foster Jacobs | jaco1924@umn.edu
Poster Location: Zone C, Number 50
Mentor: Silvia Balbo, PhD
Bio: My name is Foster Jacobs, and I am a second year Environmental Health PhD student. My focus is on environmental toxicology, and I’m particularly interested in studying biomarkers of environmental pollutants and developing methods to better assess their human health risk.
LC-HRMS characterization of cyclophosphamide-derived DNA damage to identify predictive biomarkers
Authors: Guidolin V, Jacobs FC, Spry C, MacMillan ML, Villalta PW, Balbo S
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Chiara Lecchi | clecchi@umn.edu
Poster Location: Zone C, Number 51
Mentor: Silvia Balbo, PhD
Detection of colibactin-DNA crosslinks in oligonucleotides by high-resolution mass spectrometry
Authors: Lecchi C., Carlson E., Villalta P., Balskus E., Balbo S.
Poster Session #2
Genetic Mechanisms (GM)
Ibrahim Abdelgawad, BS | Abdel217@umn.edu
Poster Location: Zone A, Number 1
Mentor: Beshay Zordoky, PhD
Bio: I am a 4th year PhD candidate in the lab of Dr. Beshay Zordoky at the Experimental and Clinical Pharmacology Department, College of Pharmacy. My PhD thesis focuses on mitigating chemotherapy-induced senescence using multiple in vivo and in vitro models.
Differential effects of the senolytic, ABT-263, against Doxorubicin-induced endothelial senescence
Authors: Abdelgawad IA, Agostinucci K, Ismail S, Grant MKO, Zordoky BN
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Marie Lue Antony, PhD | mlantony@umn.edu
Poster Location: Zone A, Number 2
Mentor: Zohar Sachs, MD.PhD
Bio: I am a research associate in the Sachs laboratory and my work is on leukemia stem cells. My work is focused on understanding the therapeutic vulnerabilities of TP53 altered human acute myeloid leukemia.
Proteasome Inhibition Attenuates Self-Renewal in AML by Targeting NF-kappa B in Leukemia Stem Cells
Authors: Antony ML, Noble-Orcutt KE, Jensen JL, He F, Sachs Z
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Minu Bhunia, BS | bhuni002@umn.edu
Poster Location: Zone A, Number 3
Mentor: David Largaespada, PhD
Bio: 4th year PhD candidate and masters student in Molecular, Cellular, Developmental Biology, and Genetics and Bioinformatics and Computational Biology programs. Studying the epigenentic origins of Malignant Peripheral Nerve Sheath Tumors.
Differential expression analysis of Schwann cells with PRC2 loss reveals potential drivers of MPNSTs
Authors: Bhunia, M, Williams, K, Williams, R, Finnerty, S, Larsson, A, Sokolowski, M, Abrahante, J, Largaespada, DA
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Kim Demos-Davies, DVM, BA | demos027@umn.edu
Poster Location: Zone A, Number 5
Mentor: Davis Seelig, DVM, PhD, DACVP
Bio: I am a PhD student in Comparative and Molecular Biosciences at the University of Minnesota. I research the neurocognitive effects of extracranial radiation therapy.
Cancer treatment induced cognitive impairment and neuroinflammation in mice.
Authors: Demos-Davies K, Rogich A, Lawrence J, Seelig D
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Elise Dunshee, BS | dunsh014@umn.edu
Poster Location: Zone A, Number 6
Mentor: Aaron Goldstrohm, PhD
Bio: Third-year PhD student in Aaron Goldstrohm's lab studying mechanisms of post-transcriptional regulation by human Pumilio proteins.
Functional mapping of human Pumilio proteins to identify regions involved in mRNA regulation
Authors: Dunshee EB, Goldstrohm AC
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Travis Gates, BA | gates173@umn.edu
Poster Location: Zone A, Number 8
Mentor: Subree Subramanian PhD
Bio: Travis Gates is a second year PhD in Subree Lab. He is interested in the interactions between the microbiome and the immune system in the colorectal cancer tumor microenvironment.
Immunomodulatory interactions in the colorectal cancer tumor microenvironment
Authors: Gates TJ, Yuan C, Wangmo D, Zhoa X, Subramanian S,
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Praveensingh Hajeri, PhD | phajeri@umn.edu
Poster Location: Zone A, Number 9
Mentor: Masato Yamamoto, MD. PhD
Bio: Researcher 5 in Dr. Masato Yamamoto's group. I am working on designing and developing Oncolytic viruses and their applications for high-throughput screening and targeted therapy.
A novel method to generate ultra-high-sequence diversity libraries of plasmids and rec-Viruses.
Authors: Hajeri PB and Yamamoto M
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Silvia Liu, BA | liu01466@umn.edu
Poster Location: Zone A, Number 10
Mentor: Hai Dang Nguyen, PhD
Bio: My name is Silvia and I'm a a second year graduate student from Dr. Nguyen's lab in the Molecular Pharmacology and Therapeutics program. My research interest lies in identifying novel therapeutic targets for MDS.
Therapeutic targeting of spliceosome mutant leukemias through PARP inhibition.
Authors: Liu ZS*, Sinha S*, Bannister M, Arriaga-Gomez E, Song A, Zong D, Corral V, Leibson C, Rai S, Graubert TA, Lee SC, Nguyen HD
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Emily Pope, BS | popex102@umn.edu
Poster Location: Zone A, Number 11
Mentor: David Largaespada, PhD
Bio: I am a dual DVM/PhD candidate in the College of Veterinary Medicine. My research interests are focused on understanding the contributions of the extracellular matrix to chemotherapy resistance in metastatic osteosarcoma.
Evaluating the role of hyaluronan in osteosarcoma pulmonary metastases.
Authors: Pope EA, Camilleri ET, Stoffield ME, Bagherzadeh S, Fukushima LM, Hudson WA, Slipek NJ, Largaespada DA
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Flavia Popescu, PhD | pope0014@umn.edu
Poster Location: Zone A, Number 12
Mentor: David Largaespada, PhD
Bio: I am a dual DVM/PhD candidate in the College of Veterinary Medicine. My research interests are focused on understanding the contributions of the extracellular matrix to chemotherapy resistance in metastatic osteosarcoma.
Recurrent Non-Normally Processed Transcripts, a Source of Neoantigens for MPNST Immunoprevention.
Authors: Popescu FE, Jubenville T, Rathe SK, Liebau J, Griffin TJ, Largaespada DA
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Saranya Prathibha, MD, BA | saranya.prathibha@gmail.com
Poster Location: Zone A, Number 13
Mentor: Christopher J. LaRocca, MD
Bio: Saranya Prathibha is a current PGY4 general surgery resident completing a quality improvement fellowship at the Minneapolis VA Medical Center. She is interested in pursuing breast oncology as a career path in the future.
Breast Cancer Screening Among Women Veterans: What Are We Doing Right?
Authors: Prathibha S, Westanmo AD, Hui JYC, Westanmo K, Gravely AA, Tuttle TM, LaRocca CJ
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Mackenzie Sheehy, BS | sheeh289@umn.edu
Poster Location: Zone A, Number 14
Mentor: David Largaespada, PhD
Bio: I am a graduate of the University of Minnesota, having completed a Bachelors of Science in Genetics, Cell Biology, and Development. During my undergraduate education I was a research assistant in Dr. David Largaespada's lab and have transitioned to be a full time researcher following completion of my degree.
Conditionally Replicating Adenovirus as Therapy for Malignant Peripheral Nervous Sheath Tumors
Authors: Sheehy, M. Nikrad, J., Jacobsen, K., Sheehy, M., Yamamoto, M., Largaespada, D.
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Zicheng Wang, PhD | wang2569@umn.edu
Poster Location: Zone A, Number 15
Mentor: Ruping Sun, PhD
Bio: Zicheng Wang is a Post-Doctoral Associate at the Department of Laboratory Medicine and Pathology at the University of Minnesota, supervised by Doctor Ruping Sun. Before joining SunPath Lab, Zicheng Wang received a Ph.D. from the Department of Industrial and Systems Engineering at the University of Minnesota, advised by Doctor Kevin Leder. His research focuses on mathematical modeling of cancer.
Evolving copy number gains promote tumor expansion and bolster mutational diversification
Authors: Zicheng Wang, Yunong Xia, Laren Mills, Athanasios Nikolakopoulos, Nicole Maeser, Jason Sheltzer, Ruping Sun
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Kyle Williams, PhD, BS | kbwillia@umn.edu
Poster Location: Zone A, Number 16
Mentor: David A. Largaespada, PhD
Bio: Kyle B. Williams Ph.D. is a postdoctoral fellow in the laboratory of Dr. David Largaespada at the University of Minnesota. Dr. Williams has focused on using genome engineering technologies, such as CRISPR/Cas9, to create cell line based tools for conducting chemical and genetic screens to investigate neurofibromatosis type 1 biology and drug susceptibility. He is a previous Children’s Tumor Foundation Young Investigator and Children’s Cancer Research Fund Emerging Scientist awardee.
Altered Epigenetic Homeostasis Provides Therapeutic Vulnerabilities in NF1-Associated MPNSTs
Authors: Williams KB, Larsson A, Tibbits J, Wang L. Bielinsky AK. Largaespada DL
Immunology (IMM)
Kate Dixon, PhD | dixon097@umn.edu
Poster Location: Zone A, Number 18
Mentor: Bruce Walcheck, PhD
Bio: I am a postdoc in Bruce Walcheck's lab.
Arming iPSC-derived NK cells Expressing a Novel CD64 Fusion Receptor to Target B Cell Lymphoma
Authors: Dixon KJ, Khaw M, Snyder KM, Hullsiek R, Matson AW, Davis Z, Lee T, Chu H, Abujarour R, Dinella J, Bjordahl B, Hancock B, Shirinbak S, Miller JS, Valamehr B, Wu J, Walcheck B
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Behiye Kodal, MS | KODA0020@UMN.EDU
Poster Location: Zone B, Number 19
Mentor: Martin Felices, PhD
Bio: I received my bachelor of science degree from the College of Biological Sciences at the University of Minnesota, with a major in Microbiology and minor in Italian. I received my Masters in Biological Sciences from the College of Continuing & Professional Studies at the University of Minnesota. I have been a researcher in the labs of Drs. Felices and Miller since Spring of 2016 focusing on NK cell immunotherapy, with expertise in flow cytometry based assays.
NK-cell-mediated targeting of B Cell malignancies with a novel CD19 Tri-Specific Killer Engager
Authors: Kodal B, Vallera DA, Hinderlie P, Bachanova V, Miller JS, Felices M
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Anders Matson, PhD | matso198@umn.edu
Poster Location: Zone B, Number 20
Targeting ADAM17 on human NK cells with a mAb increases their proliferation by IL-15
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Zoe Schmiechen, BA | schm5267@umn.edu
Poster Location: Zone B, Number 21
Mentor: Ingunn Stromnes, PhD
Bio: I graduated from Grinnell College with a BA in biochemistry. I completed a 2-year postbaccalaureate fellowship at the NIH studying the immunological mechanisms of allergic disease. I am currently in my third year of graduate school in the MICaB program at UMN.
Regulatory T cells drive antigen specific T cell exhaustion and immunosuppression in PDA
Authors: Schmiechen ZC, Burrack AL, Spartz EJ, Rollins MR, Miller EA, Stromnes IM
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Kristin Snyder, BS | snyde727@umn.edu
Poster Location: Zone B, Number 22
Mentor: Bruce Walcheck PhD
Bio: Kristin Snyder is a graduate student in the Walcheck studying natural killer cell immunotherapies.
iPSC-derived NK cells expressing novel CD64/16A armed with therapeutic mAbs to treat ovarian cancer
Authors: Snyder KM, Dixon K, Khaw M, Davis Z, Hosking M, Bjordahl R, Hancock B, Shirinbak S, Valamehr B, Wu J, Walcheck B
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Harish Venkatachalapathy, B. Tech. | venka166@umn.edu
Poster Location: Zone B, Number 23
Mentor: Samira Azarin, PhD; Casim Sarkar, PhD
Bio: Harish is a PhD Candidate (Chemical Engineering) working on cell decision making in the context of cancer biology. He uses mathematical modeling combined with in vitro experiments to elucidate mechanisms underpinning variability in cell behavior. He is co-advised by Prof. Casim Sarkar (BME) and Prof. Samira Azarin (CEMS).
Energy landscape analysis highlights the importance of cell cycle memory in breast cancer dormancy.
Authors: Venkatachalapathy H, Brzakala C, Batchelor E, Azarin SM, Sarkar CA
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Eyob Weyu, BS | weyux001@umn.edu
Poster Location: Zone B, Number 24
Mentor: David Masopust, PhD
Bio: My name is Eyob Weyu, and I'm a researcher in Dr. David Masopust's lab at the University of Minnesota. I earned my bachelor's degree from the University of Minnesota, majoring in biochemistry. Currently, I'm in the college of continuing education pursuing a master's degree in biological sciences.
Intratumoral T-cell reactivation induces APC migration to lymph nodes.
Authors: Noah Gavil, Eyob Weyu, Sathi Wijeyesinghe, Vaiva Vezys and David Masopust
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Screening, Prevention, Etiology, and Cancer Survivorship (SPECS)
Maria Martell, PhD | marte353@umn.edu
Poster Location: Zone B, Number 25
Mentor: Christopher Staley, PhD
Bio: Maria Martell is a fourth-year undergraduate study who will be earning her BS in biology with a minor in public health in May 2022. She currently serves as an Undergraduate Research Assistant in Dr. Christopher Staley's lab in the Department of Surgery.
Impact of Kras and APC oncogenes on colorectal cancer microbiome
Authors: Martell M, Ganesan N
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Transplantation and Cellular Therapy (TCT)
Cellular Mechanisms (CM)
Songyi Bae, PhD | sybae@umn.edu
Poster Location: Zone B, Number 31
Mentor: Justin Drake, PhD
Bio: Songyi completed her PhD degree in South Korea and moved to US for postdoc training. In 2019, she moved to Minnesota with her husband and joined current lab, where she studies on aggressive castration-resistant prostate cancer. Outside lab, she spends most of her time playing with her little one.
Co-dependency analysis of RET reveals ZBTB7A as a potential target in neuroendocrine prostate cancer
Authors: Bae SY, Bergom H, Day A, Greene JT, Freedman TS, Hwang JH, Drake JM
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Summer Gerhardt | gerha081@umn.edu
Poster Location: Zone C, Number 35
Mentor: Deepali Sachdev, PhD
Bio: Summer is a sophomore undergraduate perusing a BS in Genetics, Cell Biology, and Development. In the future, she plans to obtain her MD and/or PhD.
Acquired resistance to CDK4/6 inhibitors is associated with upregulated IGF1R and IR signaling
Authors: Gerhardt SL, Baar CS, Johnson IR, Sachdev D
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Courtney Baar, BS | baarx012@umn.edu
Poster Location: Zone B, Number 33
Mentor: Deepali Sachdev, PhD
Bio: I graduated from the University of MN in May 2020 and currently am a researcher in the Sachdev lab. I have been working on developing models to test effect of immunotherpaeutic drugs and cyclin dependent kinases on growth of breast cancers. I am interested in attending graduate school in the future.
Targeting hormone receptor positive breast cancer for immune destruction by natural killer cells
Authors: Johnson IJ, Chiu E, Baar CS, Miller JS, Felices M, Sachdev D
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Zhijun Guo, PhD | guox0035@umn.edu
Poster Location: Zone C, Number 36
Mentor: David Potter, MD PhD
Bio: I obtained my PhD in Medicinal Chemistry at University of Minnesota and has been working in the field of cancer biology for the last 15 years.
Microenvironment induced immune checkpoint proteins and ER+ breast cancer dormancy escape
Authors: Guo ZJ, Lei JX, Norris B, Flory C, McCarra J, Larson N, Koniar B, Schumacher R, Potter D
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Lukmanul Hakkim Faruck, PhD | lfaruck@umn.edu
Poster Location: Zone C, Number 37
Mentor: James Robinson, PhD
Bio: Lukmanul Hakkim Faruck
worked as a research associate and postdoc in Japan and South Korea
respectively. Currently Hakkim is in Hormel Institute as researcher and focusing on epigenetic dysregulation and chromosomal instability in glioma.
Coordinated disruption of H3K27 methylation and H3.3S31 phosphorylation orchestrates chromosome instability in DIPG
Authors: Hakkim FL, Charles Day, Florina Grigore, Igor Entin, Alyssa Langfald, Edward Hinchcliffe, Robinson JP
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Yuyu He, MD, MS | hexxx876@umn.edu
Poster Location: Zone C, Number 38
Mentor: Andrew Nelson, MD, PhD
Bio: I'm a scientist focus on understanding the progression of breast cancer and identifying biomarkers. I actively apply the cutting-edge big data-driven methods in my research, such as spatial genomics, spatial proteomics, bulk mRNA microarray and RNAseq.
RHAMM/HMMR is Associated with the Tumor Immune Microenvironment in Triple-Negative Breast Cancer
Authors: He Y, Barthel GM, Brown ME, McCarthy J, Schwertfeger K, Nelson A.
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Alec Horrmann, BS | horrm003@umn.edu
Poster Location: Zone C, Number 39
Mentor: Justin Drake, PhD
Bio: I am a research assistant in the Drake lab where I focus on analyzing the proteome. I graduated from the University of Minnesota in 2021 with a BS in biochemistry and am currently working towards my master’s degree in biomedical engineering.
Development of single-cell proteomics protocols for use in core facilities
Authors: Horrmann AN, Sychev ZE, Drake JM
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Jay Hou, PhD | houxx149@umn.edu
Poster Location: Zone C, Number 40
Mentor: David Odde, PhD
Bio: My PhD was advised by Professor Gerard Ateshian at Columbia University, and I studied the biomechanics of chondrocytes embedded within cartilage under deformation by developing a multiphasic and multiscale cell-tissue model in the finite element framework. I am currently a postdoc in David Odde Lab at UMN, and I am studying biophysics, biomechanics, and bioinformatics of GBM cell migration using stochastic models, migration assays, bioinformatic analysis, and AI algorithms. My future research will focus on the mechanics of GBM tumor growth, spreading, and drug delivery using the multiphasic model, and the biophysics, biomechanics, and bioinformatics of cell migration in breast cancer bone metastasis.
Biophysical and transcriptomic analysis of migratory phenotypes in glioblastoma patient cells
Authors: Hou JC, McMahon MM, Sarkaria JN, Chen CC, Odde DJ
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Megan Ludwig, PhD, BS | mlludwig@umn.edu
Poster Location: Zone C, Number 42
Mentor: Justin Drake, PhD
Bio: Originally from South Dakota, I completed my undergraduate degree at Hope College in Holland, MI. I then went on to complete my doctoral degree at the University of Michigan in the lab of Dr. Chad Brenner, where I investigated mechanisms of resistance to EGFR-targeted therapies in head and neck squamous cell carcinoma.
Investigating how proteins in extracellular vesicles promote castration resistant prostate cancer
Authors: Ludwig ML, Drake JM
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Bindeshwar Sah, PhD | sah00008@umn.edu
Poster Location: Zone C, Number 43
Mentor: Liang Liu, PhD
Bio: My research interest is focused on the identification of novel molecular targets and pathways in skin tumorigenesis, genetic and epigenetic mechanisms in cancer, which could be developing targeted cancer prevention and treatment.
Loss of CELF2 promotes skin tumorigenesis and increases drug resistance
Authors: Sah B, Singh J, Chen Z, Liu L
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Jasvinder Singh, PhD | sing0880@umn.edu
Poster Location: Zone C, Number 44
Mentor: Liang Liu PhD
Bio: I had done masters in Medical Biotechnology from Punjabi University Patiala India. After that I had done PhD in biological sciences from CSIR-Indian Institute of Integrative Medicine Jammu India. My work in PhD mainly focused on cancer biology and immunology
Histone demethylase HR suppresses breast cancer development through CELF2 tumor suppressor activity
Authors: Shen Y, Singh J, Sah B, Chen Z, Ha W, Henzler C, Su T, Xie L, Deng Y, Li G, Guo H, Lange C, Hibshoosh H, Liu L.
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Yuta Suzuki, PhD, MD | suzukiy@umn.edu
Poster Location: Zone C, Number 45
Mentor: Gaspar Kitange, MD, PhD
Bio: The Jikei University of Medicine, Japan M.D., 2008; The Jikei University of Medicine, Japan Ph.D., 2017; The Hormel Institute, University of Minnesota, Postdoctoral fellow (Mentor- Dr. Gaspar Kitange), 2022
Exportin-1 Modulates Evolution of Temozolomide Resistance in Glioblastoma
Authors: Suzuki Y, Sarkaria JN, Kitange GJ
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Sarah Tarullo, PhD | tarul004@umn.edu
Poster Location: Zone C, Number 46
Mentor: Carol Lange, PhD, Kaylee Schwertfeger, PhD, Andrew Nelson, PhD
Bio: I am a second year TREM postdoctoral fellow in the Lange, Schwertfeger, and Nelson labs. My research focuses on understanding how cross-talk between hyaluronan receptors and steroid receptor signaling may impact breast cancer progression.
RHAMM promotes tumor progression and associates with poor outcomes in breast cancer patients
Authors: Tarullo SE, He Y, Daughters C, Knutson T, Henzler C, Price M, Shanley R, Witschen P, Tolg C, Kaspar R, Hallstrom C, Gittsovich L, Sulciner M, Lee X, Forester C, Shats O, Cowan K, Yee D, Schwertfeger K, Turley E, McCarthy J, Nelson AC
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Jennifer Tuokkola, BS | tuokk002@umn.edu
Poster Location: Zone C, Number 47
Mentor: Kaylee Schwertfeger, PhD
Bio: I am a second year graduate student in the Pharmacology program working in Kaylee Schwertfeger's lab.
FGFR-mediated alterations in cholesterol homeostasis contribute to breast cancer progression
Authors: Tuokkola JE, Schwertfeger KL
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Carcinogenesis and Chemoprevention (CC)
Madjda Bellamri, PhD | bellamri@umn.edu
Poster Location: Zone C, Number 49
Mentor: Robert Turesky, PhD
Bio: I am a research assistant professor at Department of Medicinal Chemistry, Masonic Cancer Center
DNA damage and oxidative stress of tobacco smoke condensate in human bladder epithelial cells
Authors: Bellamri M, Walmsley SJ, Brown CV, Brandt KT, Wu CF, Wu MT, and Turesky RJ.
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Kyle Brandt, BS | brandtk@umn.edu
Poster Location: Zone C, Number 50
Mentor: Robert Turesky, PhD
Bio: I am a research technician in the Turesky laboratory as well as a student in the Master of Biological Sciences (MBS) program in the College of Continuing and Professional Studies.
Nornitrogen mustard and mitoxantrone induced DNA damage in MDA-MB-231 human breast cancer cells
Authors: Kyle Brandt, Madjda Bellamri, John Terrell, Carmelo J Rizzo, Robert J Turesky
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Fabia de Oliveira Andrade, PhD | deoli038@umn.edu
Poster Location: Zone C, Number 51
Mentor: Leena Hilakivi-Clarke, PhD
Bio: I have a master's degree and PhD in Experimental Nutrition though University of Sao Paulo and postdoctoral training through Georgetown University with many years experience in breast cancer research prevention. Currently I am a Researcher 5 at Hormel Institute - University of Minnesota and my research interest are cancer immunology and gut microbiome.
Effects of social isolation and an anti-inflammatory herbal mixture on breast cancer recurrence
Authors: Andrade FO, Jin L, Clarke R, Wood I, Dutton A, Anjorin C, Rubin G, Gao A, Sengupta S, FitzGerald K, Hilakivi-Clarke L.
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Mei-Kuen Tang, BS | tangx419@umn.edu
Poster Location: Zone C, Number 52
Mentor: Stephen Hecht, PhD
Bio: Graduate student from the Hecht laboratory.
Glycols: salivary identification biomarkers of e-cigarette use
Authors: Tang MK, Carmella SG, and Hecht SS.
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Other Presentations
Rana Leed, MPH | rleed@umn.edu
Poster Location: Zone B, Number 27
Mentor: Marie Rahne, MBA
Bio: The Minnesota Cancer Clinical Trials Network (MNCCTN) aims to improve cancer outcomes for all Minnesotans through greater access to cancer clinical trials in prevention and treatment.
What Can Green and Blue Do For You
Authors: Leed R, Davis B, Bartlow S, Alkire J, Rahne M, Nightingale L, Markuson L
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Christopher Wilke, PhD, MD | cwilke@umn.edu
Poster Location: Zone B, Number 28
Bio: Dr. Wilke is an assistant professor in the Department of Radiation Oncology at the University of Minnesota where he specializes in the treatment of cancers of the head/neck, brain and spine and co-directs the head and neck multidisciplinary cancer clinic. His research interests include tumor modeling and the use of advanced imaging to better predict disease responses to oncologic therapies.
The impact of head and neck multidisciplinary clinic on treatment package time during COVID-19
Authors: Wilke CT, Khaja SF
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Quincy Gu, BA | Gu.Qiangqiang@mayo.edu
Poster Location: Zone B, Number 29
Mentor: Steven N. Hart, PhD
Bio: I am a PhD candidate in biomathematics, bioinformatics and computational biology trained jointly at the University of Minnesota and Mayo Clinic College of Medicine and Sciences.
My research interests include medical image processing, digital pathology, and image genomics. I’m currently working on building artificial intelligence algorithms to support clinical melanoma diagnosis and treatments by learning the skin histology from H&E-stained Whole Slide Images.
Deep Learning in Automating Breast Cancer Diagnosis from Microscopy Images
Authors: Gu Q, Prodduturi N, Hart SN
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Quincy Gu, BA | Gu.Qiangqiang@mayo.edu
Poster Location: Zone B, Number 30
Mentor: Steven N. Hart, PhD
Bio: I am a PhD candidate in biomathematics, bioinformatics and computational biology trained jointly at the University of Minnesota and Mayo Clinic College of Medicine and Sciences.
My research interests include medical image processing, digital pathology, and image genomics. I’m currently working on building artificial intelligence algorithms to support clinical melanoma diagnosis and treatments by learning the skin histology from H&E-stained Whole Slide Images.
Using Progressive Context Encoders for Anomaly Detection in Digital Pathology Images
Authors: Gillard R, Chady M, Gu Q, Prodduturi N, Patil S, Flotte TJ, Hart SN
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Poster Session #3
Genetic Mechanisms (GM)
Daniel Chang, BS | chang682@umn.edu
Poster Location: Zone A, Number 1
Mentor: Zohar Sachs, MD/PhD
Bio: I am a 3rd year PhD student in the bioinformatics and computational biology program. I am studying to define the genetic mechanism of progression of myelodysplastic syndrome to secondary acute myeloid leukemia. I am interested in applying machine learning methods to single-cell data to help study this cancer.
Bayesian networks reveal differences in signaling between self-renewing and proliferating LSCs
Authors: Chang, D, Sachs, Z, Myers, C
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Garrett Draper, BS | drape079@umn.edu
Poster Location: Zone A, Number 3
Mentor: David Largaespada, PhD
Bio: Garrett Draper is a fourth year PhD student in the Comparative Molecular Biosciences program at the University of Minnesota in the lab of Dr. David Largaespada. His research focuses on the development of a novel preclinical model of Neurofibromatosis Type 1-associated malignant peripheral nerve sheath tumors (MPNSTs). By combining CRISPR-Cas9 and induced pluripotent stem cell (iPSC) technologies, he aims to recapitulate stages of MPNST tumorigenesis through introduction of disease relevant mutations throughout various stages of Schwan cell development.
iPSC-derived Schwann cells harboring malignant mutations fail to recapitulate NF1 tumorigenesis
Authors: Draper GM, Panken D, Patchava M, Hudson W, Largaespada DA
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Rebecca Madden, MS | madd0239@umn.edu
Poster Location: Zone A, Number 4
Mentor: Beau Webber, PhD
Temporal recapitulation of genome instability in an iPSC model of osteosarcoma
Authors: Madden, RA, Becklin KL, Mills L, Thue N, Carroll N, DeFeo A, Moriarity BS, Webber BR.
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Nicole Maeser, BA | maese004@umn.edu
Poster Location: Zone A, Number 5
Mentor: Ruping Sun, PhD
Bio: I am a second-year PhD student with a background in machine learning and cancer biology. My work is focused on developing and deploying applications in the context of cancer genetics and tumor evolution. I am passionate and inspired to make a difference in cancer research.
Applications of Machine Learning for Refined SCNA Detection and Tumor Evolution Study
Authors: Maeser, Nicole
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Marissa Oram, BA | oramx003@umn.edu
Poster Location: Zone A, Number 6
Mentor: Anja-Katrin Bielinsky, PhD
Bio: Marissa Oram is a 6th year graduate student in Dr. Anja-Katrin Bielinsky’s laboratory studying the function of mammalian RNF4. In 2013, she received her B.A. in Chemistry from the College of Saint Benedict/St. John’s University. Prior to starting graduate school, she worked in Dr. Lisa Peterson’s laboratory investigating tobacco carcinogens in rodent tumor models.
Targeting RNF4 for effective colon cancer therapy
Authors: Oram MK, Chang YC, Baxley RM, Bielinsky AK
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Sara Osum, PhD, DVM | isaks047@umn.edu
Poster Location: Zone A, Number 7
Mentor: David Largaespada, PhD
Bio: Sara Osum graduated from the UMN DVM/PhD program in 2019. She is now a postdoctoral researcher using a genetically engineered minipig model to better understand the role of the tumor microenvironment in Neurofibromatosis type 1-associated cutaneous neurofibromas.
The cooperating effect of fibroblasts and Schwann cells on neurofibroma growth and maintenance
Authors: Osum SH, Oribamise E, Rathe S, Taisto M, Coutts A, Vitte J, Ratner N, Giovannini M, Moertel C, Watson AL, Largaespada DA
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Jesenia Perez, BS | perez888@umn.edu
Poster Location: Zone A, Number 8
Mentor: Stefani N. Thomas, PhD
Bio: Jesenia received her Bachelors in Biological Sciences in 2020 from Florida International University in Miami, Florida. She currently works in the Thomas lab characterizing the proteomic landscape of high grade serous ovarian cancer.
BRCA1/2 mutation-associated PARPi-induced proteomes of high-grade serous ovarian cancer cells
Authors: Perez JM, Guan W, Thomas SN
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Brett Roach, MS, BS | roach229@umn.edu
Poster Location: Zone A, Number 9
Mentor: Masato, Yamamoto, MD, PhD
Bio: I am a third year graduate student in the MCDB&G program. I work in Dr. Masato Yamamoto's lab where we work on genetically engineering oncolytic adenoviruses (OAds) to target cancers of the gastrointestinal tract. My project specifically focuses on targeting pancreatic cancer using "armed" OAds expressing various immunoproteins in conjunction with engineered T-cells.
Targeting pancreatic cancer using "armed" oncolytic adenoviruses and adoptive T cell therapy
Authors: Roach BL, Yamamoto M
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Jessica Velguth, BS | kennedy7@umn.edu
Poster Location: Zone A, Number 10
Mentor: Tim Starr, PhD
Bio: Jessica is a graduate student in Bioinformatics and Computational Biology program, and works with Dr. Tim Starr to study ovarian cancer using single cell RNA sequencing. Her previous work experience that led her to Dr. Starr's research was in clinical trials and as a lab manager in a bioinformatics lab. When not working on her graduate project, Jessica is either working (in the Cardiology Division in the Department of Medicine), reading, gardening, spending time with friends, or, typically, spending time with her two kids.
Macrophage Analysis in Ovarian Cancer using Single Cell RNAseq
Authors: Velguth JF, Mills LJ, Shetty M, Talukdar S, Wang J, Nelson A, Winterhoff B, Starr TK
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Dawei Zong, MS | zong0021@umn.edu
Poster Location: Zone A, Number 11
Mentor: Hai Dang Ngiyen, PhD
Molecular determinants for the lethality between PARP inhibitors and RNA splicing modulating
Authors: Dawei Z
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Immunology (IMM)
Quinlan Kile, BS | kilex026@umn.edu
Poster Location: Zone A, Number 12
Mentor: Pippa Kennedy, PhD
Bio: Quinlan Kile has worked for Dr. Pippa Kennedy within Prof Jeffrey Miller's Lab for the past year. Her broad focus includes research on Natural Killer (NK) cells and their potential in cancer immunotherapy, with expertise in advanced live cell imaging, 3D tumor models, and induced pluripotent stem cell-derived NK cells.
Driving natural killer cell immunotherapy towards mesothelioma
Authors: Kile QM, Kennedy PR, Jacobson BA, Ettestad B, Vallera DA, Zorko NA, Hallstrom C, Kodal B, Todhunter DA, Miller JS, Patel MR, Felices M.
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Sachinthani Erandika Senevirathne, MS, BS | senev009@umn.edu
Poster Location: Zone A, Number 13
Mentor: Tanya S Freedman, PhD
The initiation of the macrophage inflammatory response is regulated by the dose of Lyn kinase
Authors: S. Erandika Senevirathne, Tanya S Freedman
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Nicholas Zorko, PhD, MD | zorko004@umn.edu
Poster Location: Zone A, Number 14
Mentor: Jeffrey S. Miller, MD
Bio: Nicholas Zorko is a clinical fellow completing his research training in the lab of Dr. Jeffrey Miller with additional mentoring support from Drs. Martin Felices and Emmanuel Antonarakis. His work focuses on the development of natural killer cell therapies to treat refractory solid tumors. He will be joining the faculty at the University of Minnesota in July of 2022 with a clinical focus on immune therapies for genitourinary malignancies and bone marrow transplantation/cellular therapy.
Camelid Nanobody-based NK Cell Engager Molecules Targeting B7-H3 Expressing Malignancies
Authors: Zorko NA, Walker J, Lenvik A, Lenvik T, Hinderlie P, Khaw M, Phung G, Soignier Y, Hwang J, Felices M, Miller JS
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Screening, Prevention, Etiology, and Cancer Survivorship (SPECS)
Corinne Praska, BS | prask007@umn.edu
Poster Location: Zone B, Number 15
Mentor: Jane Hui, MD, MS
The effects of HER2 positivity on invasive lobular carcinoma of the breast
Authors: Prathibha S, Marmor S, Praska CE, White M, Kolbow M, Ankeny J, LaRocca C, Jensen E, Tuttle T, Hui JYC
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Corinne Praska, BS | prask007@umn.edu
Poster Location: Zone B, Number 16
Mentor: Jane Hui, MD, MS
Oncologic outcomes of patients with lymph node-positive Merkel cell carcinoma with unknown primary
Authors: Hui JYC, Prathibha S, White M, Praska CE, Kolbow M, LaRocca CJ, Ankeny J, Domingo-Musibay E, Fiessinger L, Jensen EH, Tuttle TM, Marmor S
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Gabriela Bustamante, PhD | busta027@umn.edu
Poster Location: Zone A, Number 17
Mentor: Michele Allen, MD
Bio: Gabriela is a postdoctoral fellow in the NIH-funded Cancer Health Disparities T32 Training Program at the University of Minnesota. Overall, her research examines the role of social determinants of health, with an emphasis on the neighborhood physical and social context, on the development of cancer and other chronic diseases. Most recently, her research is focused on three broad and complementary areas of research: (1) Identifying disparities in cervical cancer prevention among underserved populations, (2) Understanding the role of neighborhood and the socio-biological pathways through which it leads to cancer morbidity and mortality, particularly among immigrants, and (3) Community-based participatory interventions to eliminate disparities in preventable cancers.
Un poco de luz: Learning from cervical cancer screening among uninsured Hispanics in Minnesota
Authors: Cruz M, Jensen A, Pakonen J, Bustamante G, Gutierrez R.
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Mohamed Dabour, MS, BS | dabou003@umn.edu
Poster Location: Zone B, Number 19
Mentor: Beshay Zordoky, MSc, PhD
The Protective Effect of Canagliflozin against Carfilzomib-induced Endothelial Toxicity
Authors: Dabour MS, Abdelgawad IY, Grant MK, Zordoky BN
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Anna Fryxell, BS
Poster Location: Zone B, Number 20
Mentor: Dana Carroll, PhD
Bio: I am a second-year master's student in the environmental health program. My specific areas of interest are water quality and clean water access.
Utilizing traditional tobacco to reframe what tobacco is and is not to promote commercial smoking cessation in Native Americans: rationale, partnership goals, and program development
Authors: 2 Anna Fryxell (presenter), 1 Dylan Jennings, 2 Dorothy Hatsukami, & 2 Dana Mowls Carroll 1 Bad River Band of the Lake Superior Tribe of Chippewa Indians 2 Tobacco Research Programs, Masonic Cancer Center, University of Minnesota
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Mari Gades, BS
Poster Location: Zone B, Number 21
Mentor: Dorothy Hatsukami, PhD
Bio: Mari Gades is a PhD candidate in Cognitive and Brain Sciences at the UMN, studying e-cigarettes as a harm reduction tool for smoking. Following her PhD, she hopes to teach undergraduate level psychology in community colleges and liberal arts colleges. Outside of academia, Mari enjoys baking, crocheting, and going on hikes with her dog and partner.
Nicotine and flavor effects on electronic cigarette addiction potential and appeal for adult smokers
Authors: Gades MS, Usman A, Hatuskami D
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Malina Peterson, BS | pete9929@umn.edu
Poster Location: Zone B, Number 22
Mentor: David Pearson, MD, FAAD
Bio: Malina Yamashita Peterson is a third year medical student at University of Minnesota.
Skin Cancer Risk in Immunosuppressed Autoimmune Connective Tissue Disease Patients: Interim Analysis
Authors: Peterson MY, Jacobsen AA, Totoratis K, Buonomo M, Ruggiero J, Johnson H, Rubin N, Pearson DR
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Shuo Wang, PhD | wang8310@umn.edu
Poster Location: Zone B, Number 23
Mentor: Anna Prizment, PhD
Bio: Shuo Wang is a PhD student in Epidemiology with specific training in cancer epidemiology. Her project focuses on the use of biomarkers of aging to better understand aging consequences related to cancer and cancer treatment.
Proteomic aging clock associated with overall mortality in cancer survivors
Authors: Wang S, Blaes AH, Thyagarajan B, Pankow JS, Guan W, Prizment A
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Lindsey Wanberg, BA
Poster Location: Zone B, Number 24
Mentor: Deanna Teoh, MD MS
Bio: Lindsey Wanberg is a second-year medical student attending the University of Minnesota Medical School. She graduated from Washington University in St. Louis in 2018 with a degree in Psychological and Brain Sciences. She has interests in cancer prevention, health equity, and medical education.
Feasibility testing of a cervical cancer screening Game-based Learning Avatar-navigated mobile app
Authors: Wanberg LJ, Kim A, Vogel RI, Sadak KT, Teoh D
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McKenzie White, MD, BS | akers080@umn.edu
Poster Location: Zone B, Number 25
Mentor: Eric Jensen, MD
Bio: I am a PGY4 surgical resident at the University of Minnesota, currently working in both clinical outcomes and basic science research. I obtained my MD from Western Michigan University in 2018, and plan to pursue a fellowship in surgical oncology following completion of residency. I hope to return to my home state of Alaska to augment access to cancer care for the rural and Native populations of the state.
Nationwide disparities in post-mastectomy reconstruction for American Indian and Alaska Native women
Authors: White MJ, Prathibha S, Praska C, Ankeny JS, LaRocca CJ, Jensen EH, Tuttle TM, Hui JYC, Marmor S
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Ayaantuu Usman, currently completing BS | usman033@umn.edu
Poster Location: Zone B, Number 26
Mentor: Dorothy Hatsukami, PhD
Bio: Ayaantuu is a current student at the University of Minnesota -Twin Cities studying neuroscience and psychology. She plans to apply to medical school and work in pediatric neurology with a focus on serving underserved communities to reduce health disparities.
Assessing Filter Ventilation Among Menthol Smokers: Impact on Predominantly African American Smokers
Authors: Usman AF
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Transplantation and Cellular Therapy (TCT)
Cellular Mechanisms (CM)
Karina Deniz, BS | kdeniz@umn.edu
Poster Location: Zone B, Number 31
Mentor: Emil Lou, MD PhD
The Orientation of TTFields Disrupts Intercellular Communication Networks in Malignant Mesothelioma
Authors: Deniz K, Ladner K, Wong P, Padmanabhan Y, Lou E
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Jacque Lyman, BS | lyman076@umn.edu
Poster Location: Zone C, Number 32
Mentor: Scott Dehm, PhD
Bio: Jacque Lyman is a first year PhD student in MCDB&G. Her professional interests surround personalized treatment of genetic diseases. She is part of the University of Minnesota joint degree program intersecting genetic counseling with laboratory research.
Exploring Biomarkers in a Phase II Trial of Sacituzumab Govitecan in Advanced Prostate Cancer
Authors: Lyman J, Knutson TP, Sperger J, Kyriakopolous C, Slovin S, Tagawa S, Lang JM, Dehm SM
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Sean McSweeney, MD | mcswe027@umn.edu
Poster Location: Zone C, Number 33
Mentor: Justin Hwang, PhD
Bio: Sean McSweeney is a current fourth year medical student at The University of Minnesota with keen interests in urologic oncology, particularly within genetics and genomics of prostate cancer. Sean will be graduating medical school in May of this year and then be off to a residency in Urology at the Cleveland Clinic for the next six years.
Androgen Production, Uptakes and Conversation genes converge as a signaling pathway and are target genes in metastatic castration resistant prostate cancer
Authors: Sean McSweeney, Hannah Bergom, Eamon Toye, Charles Ryan, Justin Hwang
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Minnu Monu, MD | monu0004@umn.edu
Poster Location: Zone C, Number 34
Mentor: Emil Lou, MD PhD
Differential Expression of SSTR Subtypes Across a spectrum of Neuroendocrine Neoplasms (NENs)
Authors: Differential Expression of SSTR Subtypes Across a spectrum of Neuroendocrine Neoplasms (NENs)
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Sanyukta Padmanabhan, High School Degree | padma034@umn.edu
Poster Location: Zone C, Number 35
Mentor: Emil Lou, MD, Ph.D.
Tunneling Nanotube Imaging in an In Vivo Modal of Ovarian Cancer
Authors: Sanyukta Padmanabhan, Venugopal Thayanithy, Karina Deniz, Katherine Ladner, Phillip Wong, Guillermo Marques, Rachel Vogel, Clifford J Steer, Subbaya Subramanian, Emil Lou
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Sam Pitzen, BA | pitze022@umn.edu
Poster Location: Zone C, Number 36
Mentor: Scott Dehm, PhD
KLF5 Drives Basal Cell Identity to Promote Prostate Cancer Lineage Plasticity and Progression
Authors: Pitzen SP, Che M, Murugan P, Forster C, Dehm SM
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Natasha Roman, BS | roman449@umn.edu
Poster Location: Zone C, Number 37
Mentor: Julie Ostrander, PhD
Targeting breast cancer stem cells with oncolytic virus
Authors: Roman N, Danthi P, Ostrander J
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Xiaolei Shi, PhD, MD | shixx121@umn.edu
Poster Location: Zone C, Number 38
Mentor: Justin Hwang, PhD
Bio: Currently in the 2nd year of internal medicine residency training. PhD from UT Southwestern Medical Center studying cancer metabolomics and HHMI international student fellowship laureate. MD from China.
Molecular correlates of high B7-H3-expressing metastatic castrate-resistant prostate cancers (mCRPC)
Authors: Shi X, Day A, Bergom HE, Tape S, Baca SC, Ryan CJ, Zorko N, Antonarakis NS, Hwang J
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Zoi Sychev, PhD | zsychev@umn.edu
Poster Location: Zone C, Number 39
Mentor: Justin Drake PhD
Global Proteome Analysis of Prostate Cancer Patient Derived Xenografts Tumors from the LuCaP series
Authors: Sychev, ZE; Larson, G ; Horrmann, A; Ludwig, M; Corey, E; Drake, JM, Pharmacology
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Zoi Sychev, PhD | zsychev@umn.edu
Poster Location: Zone C, Number 40
Mentor: Justin Drake PhD
Identification of Androgen Receptor variants using Targeted Mass Spectrometry based proteomics
Authors: Sychev ZE, Dehm S, Drake JM
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Kiel Tietz, PhD | tietz025@umn.edu
Poster Location: Zone C, Number 41
Mentor: Scott Dehm, PhD
Bio: Postdoctoral fellow interested in mechanisms of mRNA regulation that drive prostate cancer progression.
Alternative Polyadenylation as a Therapeutic Vulnerability in Prostate Cancer
Authors: Tietz KT, Van Etten JL, Munro SA, Miller JT, Dehm SM
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José Valentín López, BS | valen489@umn.edu
Poster Location: Zone C, Number 42
Mentor: Scott Dehm, PhD
Bio: José Valentín López is a first year graduate student in the University of Minnesota Medical Scientist Training Program (MSTP). He holds a Bachelor's Degree in Natural Sciences with a concentration in Chemistry from the University of Puerto Rico at Cayey.
Elucidating the Role of Androgen Receptor Variants in Prostate Cancer Lipid Metabolism
Authors: Valentín López, JC; Ho, Y; Dehm, SM
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Ralph White, BS | whit2487@umn.edu | Twitter @RalphWhiteIII
Poster Location: Zone C, Number 43
Mentor: Justin Drake
Bio: Ralph White is now a 5th year PhD Candidate in the Department of Pharmacology at the University of Minnesota. His research focus involves evaluating synergy between kinase inhibitors and the standard of care therapeutics against Castration Resistant Prostate Cancer. In addition to research, Ralph is involved in STEM outreach, engaging all with his love of cellular biology and chemistry.
Evaluating Synergy Between Enzalutamide And SRC Inhibitors In Castration-Resistant Prostate Cancer
Authors: White III, R, Tan V, Drake J
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Tingyuan Yang, MS | yang6906@umn.edu
Poster Location: Zone C, Number 44
Mentor: Ameeta Kelekar, PhD
Human Noxa regulates both the proliferative and the apoptotic phases of a CD8 T cell immune response
Authors: Yang T, Elmer S, Krecke KN, Benson J, Pennell C and Kelekar A
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Andrej Zivanovic, BS | zivan003@umn.edu
Poster Location: Zone C, Number 45
Mentor: Scott Dehm, PhD
AR-targeted linked-read sequencing reveals complex AR structural variants in CRPC tumors and models
Authors: Zivanovic A, Munro SA, Miller J, Li Y, Passow C, Raphael BJ, Simonaitis P, Dehm SM
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Carcinogenesis and Chemoprevention (CC)
Andrew Elton, BS | elton024@umn.edu
Poster Location: Zone C, Number 47
Mentor: Frank Ondrey, MD, PhD
Metformin Effects on Metabolomics in a Murine Lung Adenoma Model
Authors: Andrew Elton, Vannesa Cedarstrom, Arman Quraishi, Beverly Wuertz, Donna Seabloom, Frank Ondrey
Link to Abstract
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Joas da Silva, PhD | lucas334@umn.edu
Poster Location: Zone C, Number 48
Mentor: Leena Hilakivi-Clarke
Walnuts prevent reduced heartbeat caused by letrozole in a zebrafish model
Authors: da Silva JL, Hoeppner LH, Blaes A, Hilakivi-Clarke L
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Lisa Peterson, PhD | peter431@umn.edu
Poster Location: Zone C, Number 49
Tobacco-specific nitrosamine-derived pyridyloxobutyl DNA adducts yield a unique mutational signature
Authors: Peterson, LA, Temiz,A, Hecht SS, Vevang, KE, Guo, J, Mayel, T, Renard, C, Cros, MP, Chavanel, B, Keita, S, Virard, F, Korenjak, M, and Zavadil, J.
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An Trinh | trinh069@umn.edu
Poster Location: Zone C, Number 50
Mentor: Lisa Peterson, PhD
Bio: An Trinh is a junior studying chemistry and plans to attend graduate school in toxicology.
Characterization of Urinary and Hepatocyte Furan Metabolites
Authors: Trinh A, Peterson L, Vevang K
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Karin Vevang, BA | shafe030@umn.edu
Poster Location: Zone C, Number 51
Mentor: Lisa A Peterson, PhD
Bio: I'm the project coordinator for HHEAR as well as a generalist in the lab; I worked in medical laboratory prior to research. Along with several undergraduate researchers, I've done helped study furan metabolites in the Peterson lab. I have a 3 year old daughter and husband at home as well as a cat.
Furan metabolites are elevated in users of various tobacco products and marijuana.
Authors: Vevang, KR, Murphy, SE, Hecht, SS, Hatsukami, D, Oppeneer Nomura, S Robien, K, Grill, A, Peterson, LA
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Francisco Gomez, MS | gomez232@umn.edu
Poster Location: Zone C, Number 52
Mentor: Irina Stepanov, PhD
Bio: Francisco Gomez is an analytical chemist trained in inorganic and bioinorganic chemistry. At the MCC, he works for the Stepanov Lab in the quantification of metals and metalloids in human biosamples.
Urinary Levels of Arsenic, Lead, and Cadmium in African-American and White Smokers
Authors: Gomez FJ, Cigan S, Jensen J, Hatsukami D, Stepanov I
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Other Presentations
Michael Anderson, BS | and08240@umn.edu
Poster Location: Zone B, Number 28
Mentor: Wendy Gordon, PhD
Bio: Michael Anderson is a 4th year MD/PhD student currently in the Wendy Gordon laboratory. He is studying how cancer cell changes to the dystrophin-glycoprotein complex (DGC) affect cellular behavior and biophysical profile.
Dystroglycan proteolysis is conformationally-regulated and disrupted by cancer-associated mutations
Authors: Anderson MJM, Hayward AN, Grant E, Greenberg L, Aird EJ, Evans R, Gordon WR
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Lorraine Mascarenhas, DO | masca014@umn.edu
Poster Location: Zone B, Number 29
Mentor: Anne Melzer, MD
Tobacco Cessation Treatment Training and Evaluation Among Medical Trainees: An Ongoing Gap
Authors: Mascarenhas L, Reese Z, Deepak J, Clancy C, Gesthalter Y, Gogineni H, Hart* J, Melzer* A, *Denotes co-senior author
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Meena Murugappan, PhD, MPH, PharmD | murug005@umn.edu
Poster Location: Zone B, Number 30
Mentor: Joel Farley, PhD and Randall Seifert, PharmD
Bio: Meena Murugappan is a PhD candidate in Pharmaceutical Outcomes and Policy research at the University of Minnesota College of Pharmacy and Research Fellow at the U.S. Food and Drug Administration Oncology Center of Excellence. She holds a PharmD and MPH in Epidemiology from the University of Minnesota. Her dissertation focuses on using Patient Reported Outcomes to measure frailty in patients with Multiple Myeloma. After graduation, Meena aspires to build a career in cancer drug policy research.
Measuring Physical Functioning in Breast Cancer
Authors: Murugappan MN, King-Kallimanis B, Mangir C, Howie L, Bhatnagar V, Beaver J, Basch E, Kluetz P
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