Publications

Highlighted publications:

Mulloy SM, Aback EM, Gao R, Engel S, Pawaskar K, Win C, Moua A, Hillukka L and AM Lee. Subregion and sex differences in ethanol activation of cholinergic and glutamatergic cells in the mesopontine tegmentum. Scientific Reports, January 2024, Jan 2;14(1):46.

Gao R, Schneider AM, Mulloy SM and AM Lee. Expression pattern of nicotinic acetylcholine receptor subunit transcripts in neurons and astrocytes in the ventral tegmental area and locus coeruleus. European Journal of Neuroscience, Aug 2023, doi: 10.1111/ejn.16109, online ahead of print. 

DeBaker MC, Mitten EH, Rose TR, Marron Fernandez de Velasco E, Gao R, Lee AM and K Wickman. RGS6 negatively regulates inhibitory G protein signaling in ventral tegmental area dopamine neurons and positively regulates binge-like alcohol consumption in mice. Br J Pharmacol, 2023, Aug;180(16):2140-2155.

Wadsworth HA, Anderson EQ, Williams BM, Ronstrom PJW, Moen JK, Lee AM, McIntosh JM, Wu J, Yorgason JT and SC Steffensen. Role of alpha6-nicotinic receptors in alcohol-induced GABAergic synaptic transmission and plasticity to cholinergic interneurons in the nucleus accumbens. Molecular Neurobiology, 2023, Jun;60(6):3113-3129.

El Banna FK, Otto JM, Mulloy SM, Tsai W, McElroy SM, Wong AL, Cutts G, Vrieze SI and AM Lee. Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption. Scientific Reports, 2022, doi: 10.1038/s41598-022-13283-1.

Moen JK and AM Lee. Sex differences in the nicotinic acetylcholine receptor system of rodents: impacts on nicotine and alcohol reward behaviors. Frontiers in Neuroscience, 2021, Sept 21; https://doi.org/10.3389/fnins.2021.745783

DeBaker MC, Fernandez de Velasco EM, McCall NM, Lee AM and K Wickman. Differential impact of inhibitory G protein signaling pathways in ventral tegmental area dopamine neurons on behavioral sensitivity to cocaine and morphine. eNeuro, 2021, Mar 10; doi: 10.1523/ENEURO.0081-21.2021.

Moen JK, DeBaker MC, Myjak JE, Wickman K and AM Lee.  Bidirectional sex-dependent regulation of α6 and β3 nicotinic acetylcholine receptors by protein kinase Cε. Addiction Biology, 2021, May;26(3):e12954, https://doi.org/10.1111/adb.12954

Touchette JC*, Moen JK*, Robinson JM and AM Lee.  Enhancement of alcohol aversion by the nicotinic acetylcholine receptor drug sazetidine-A.  Addiction Biology, 2021, Mar;26(2):e12908. https://doi.org/10.1111/adb.12908 

Wong AL, McElroy SM, Robinson JM, Mulloy SM, El Banna FK, Harris AC, LeSage MG and AM Lee. Flavor-specific enhancement of electronic cigarette refill liquid consumption in mice.  Drug and Alcohol Dependence, 2020, Jun 1;211:107995. https://doi.org/10.1016/j.drugalcdep.2020.107995

DeBaker MC, Moen JK, Robinson JM, Wickman K and AM Lee.  Unequal interactions between alcohol and nicotine co-consumption: Suppression and enhancement of concurrent drug intake.  Psychopharmacology (Berl), 2020, Apr;237(4):967-978.

DeBaker MC*, Robinson JM*, Moen JK, Wickman K and AM Lee.  Differential patterns of alcohol and nicotine intake: Combined alcohol and nicotine binge consumption behaviors in mice.  Alcohol, 2020, June;85:57-64. 

Blasio A, Wang J, Wang D, Varodayan FP, Pomrenze MB, Miller J, Lee AM, McMahon T, Gyawali S, Wang H-Y, PhD; Roberto M, McHardy S, Pleiss MA and RO Messing.  Novel Small Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice.  Biol Psychiatry, 2018, Aug 1;84(3):193-201.

Touchette JC, Maertens JJ, Mason MM, O’Rourke KY and AM Lee.  The nicotinic receptor drug sazetidine-A reduces alcohol consumption in mice without affecting concurrent nicotine consumption. Neuropharmacology, 2018, Feb 2;133:63-74. 

Touchette JC and AM Lee.  Assessing alcohol and nicotine co-consumption in mice.  Oncotarget, 2017, Jan 24;8(4);5684-5685.

O’Rourke KY, Touchette JC, Hartell EC, Bade EJ and AM Lee.  Voluntary co-consumption of alcohol and nicotine: Effects of abstinence, intermittency, and withdrawal in mice.  Neuropharmacology, 2016, Oct, 109:236-46.

Lee AM, Wu D-F, Dadgar J, Wang D, McMahon T and RO Messing.  Protein kinase C epsilon phosphorylates α4β2 nicotinic acetylcholine receptors and promotes recovery from desensitization.  Br J Pharmacol, 2015, Sept, 172(17):4430-41.

Lee AM, Zou ME, Lim JP, Stecher J, McMahon T and RO Messing.  Deletion of Prkcz increases intermittent ethanol consumption in mice.  Alcohol Clin Exp Res, 2014, Jan, 38(1):170-8.

Lee AM, Kanter BR, Wang D, Lim JP, Zou ME, Qiu C, McMahon T, Dadgar J, Fischbach-Weiss SC and RO Messing.  Prkcz null mice show normal learning and memory.  Nature, 2013, Jan 17, 493(7432):416-9.

Lee AM and RO Messing.  Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens.  Proc Natl Acad Sci USA, 2011, Sept 20; 108(38):16080-5.