Publications

2016

85. Tanja Štular, Samo Lešnik, Kaja Rožman, Julia Schink, Mitja Zdouc, An Ghysel, Feng Liu, Courtney C. Aldrich , V. Joachim Haupt, Sebastian Salentin , Simone Daminelli, Michael Schroeder, Thierry Langer○, Stanislav Gobec, Dušanka Janeži, and Janez Konc. Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction. J. Med. Chem., 2016, 59 (24), pp 11069–11078. DOI: 10.1021/acs.jmedchem.6b01277

84. William D. Fiers, Greg J. Dodge, David H. Sherman, Janet L. Smith, and Courtney C. Aldrich. Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis. J. Am. Chem. Soc., 2016, 138 (49), pp 16024–16036. DOI: 10.1021/jacs.6b09748

83. Meredith A. Skiba, Andrew P. Sikkema, William D. Fiers, William H. Gerwick, David H. Sherman, Courtney C. Aldrich, Janet L. Smith. Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase. ACS Chem. Biol., 2016, 11 (12), pp 3319–3327. DOI: 10.1021/acschembio.6b00759

82. Joshua M. Thiede, Shannon L. Kordus, Breanna J. Turman, Joseph A. Buonomo, Courtney C. Aldrich, Yusuke Minato & Anthony D. Baughn. Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates. Nature Scientific Reports. 6, Article number: 38083 (2016) DOI:10.1038/srep38083.

81. Bradley R. Miller, Eric J. Drake, Ce Shi, Courtney C. Aldrich and Andrew M. Gulick. Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture. J. Bio. Chem. 2016 Volume: 291 Issue: 43 Pages: 22559-22571. DOI: 10.1074/jbc.M116.746297

80. Misty L. Kuhn, Evan Alexander, George Minasov, Holland J. Page, Zdzislaw Warwrzak Ludmilla Shuvalova, Kristin J. Flores, Daniel J. Wilson Ce Shi, Courtney C. Aldrich, Wayne F. Anderson. Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis. ACS Infect. Dis., 2016, 2 (8), pp 579–591. DOI: 10.1021/acsinfecdis.6b00082

0

79. Anna Krajczyk, Joanna Zeidler, Piotr Januszczyk, Surendra Dawadi, Helena I. Boshoff, Clifton E. Barry, Tomas Ostrowskia , Courtney C. Aldrich, 2-Aryl-8-aza-3-deazaadenosine analogues of 5′-O-[N-(salicyl)sulfamoyl]adenosine: Nucleoside antibiotics that block siderophore biosynthesis in Mycobacterium tuberculosis. Bioorgainic Med. Chem. Volume 24, Issue 14, 15 July 2016, Pages 3133–3143. DOI: 10.1016/j.bmc.2016.05.037

78. Surendra Dawadi, Shuhei Kawamura, Anja Rubenstein, Rory Remmel, Courtney C. Aldrich. Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis. Bioorganic Med. Chem. Lett. Volume 24, Issue 6, 15 March 2016, Pages 1314–1321. DOI: 10.1016/j.bmc.2016.02.002

77. Eric J. Drake, Bradley R. Miller, Ce Shi, Jeffrey T. Tarrasch, Jesse A. Sundlov, C. Leigh Allen, Georgios Skiniotis, Courtney C. Aldrich, Andrew M. Gulick. Structures of two distinct conformations of holo-non-ribosomal peptide synthetases. Nature 529, 235–238 (14 January 2016) doi:10.1038/nature16163

76. Duckworth, Benjamin R.; Wilson, Daniel J.; Aldrich, Courtney C. Measurement of Nonribosomal Peptide Synthetase Adenylation Domain Activity Using a Continuous Hydroxylamine Release Assay. NONRIBOSOMAL PEPTIDE AND POLYKETIDE BIOSYNTHESIS: METHODS AND PROTOCOLS Book Series: Methods in Molecular Biology Volume: 1401 Pages: 53-61 Published: 2016

2015

75. Sonali Srivastava, Sarika Chaudhary, Lipi Thukral, Ce Shi, Rinkoo D. Gupta, Radhika Gupta, K. Priyadarshan, Archana Vats, Asfarul S. Haque, Rajan Sankaranarayanan, Vivek T. Natarajan, Rakesh Sharma, Courtney C. Aldrich, Rajesh S. Gokhale. Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase. Cell. Volume 22, Issue 12, 17 December 2015, Pages 1577–1587. DOI: 10.1016/j.chembiol.2015.10.009

74. Buonomo, J. A. and Aldrich, C. C. (2015), Mitsunobu Reactions Catalytic in Phosphine and a Fully Catalytic System. Angew. Chem. Int. Ed., 54: 13041–13044. doi:10.1002/anie.201506263

73. Magdalena Makowska-Grzyska, Youngchang Kim, Suresh Kumar Gorla, Yang Wei, Kavitha Mandapati, Minjia Zhang, Natalia Maltseva, Gyan Modi, Helena I. Boshoff, Minyi Gu, Courtney Aldrich, Gregory D. Cuny, Lizbeth Hedstrom, Andrzej Joachimiak. Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. PLoS One. 2015; 10(10): 2015 Oct 6. DOI: 10.1371/journal.pone.0138976

72. Kathryn M. Nelson, Kishore Viswanathan, Surendra Dawadi, Benjamin P. Duckworth, Helena I. Boshoff§, Clifton E. Barry, and Courtney C. Aldrich. Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis. J. Med. Chem., 2015, 58 (14), pp 5459–5475. DOI: 10.1021/acs.jmedchem.5b00391

71. Ran Dai, Todd W. Geder, Feng Liu, Sae Woong Park, Dirk Schnappinger, Courtney C. Aldrich, and Barry C. Finzel Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J. Med. Chem., 2015, 58 (13), pp 5208–5217. DOI: 10.1021/acs.jmedchem.5b00092

70. Yang Li, Greg J. Dodge, William D. Fiers, Robert A. Fecik, Janet L. Smith, and Courtney C. Aldrich Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase. J. Am. Chem. Soc., 2015, 137 (22), pp 7003–7006. DOI: 10.1021/jacs.5b02325

69. Surendra Dawadi, Kishore Viswanathan, Helena I. Boshoff, Clifton E. Barry, and Courtney C. Aldrich. Investigation and Conformational Analysis of Fluorinated Nucleoside Antibiotics Targeting Siderophore Biosynthesis. J. Org. Chem., 2015, 80 (10), pp 4835–4850. DOI: 10.1021/acs.joc.5b00550

68. Sae Woong Park, Dominick E. Casalena, Daniel J. Wilson, Ran Dai, Partha P. Nag, Feng Liu, Jim P. Boyce, Joshua A. Bittker, Stuart L. Schreiber, Barry C. Finzel, Dirk Schnappinger Courtney C. Aldrich. Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium Cell. Volume 22, Issue 1, 22 January 2015, Pages 76–86 DOI:10.1016/j.chembiol.2014.11.012

67. William D. Fiers, Greg J. Dodge, Yang Li, Janet L. Smith, Robert A. Fecik and Courtney C. Aldrich. Tylosin polyketide synthase module 3: stereospecificity, stereoselectivity and steady-state kinetic analysis of β-processing domains via diffusible, synthetic substrates. Chem. Sci., 2015, 6, 5027-5033 DOI: 10.1039/C5SC01505G

66. Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D, Finzel BC, Aldrich CC. Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors. J. Med. Chem. 2015 Sep 24;58(18):7349-69. DOI: 10.1021/acs.jmedchem.5b00719.

65. Liu Z, Liu F, Aldrich CC. Stereocontrolled Synthesis of a Potential Transition-State Inhibitor of the Salicylate Synthase MbtI from Mycobacterium tuberculosis. J. Org. Chem. 2015 Jul 2;80(13):6545-52. DOI: 10.1021/acs.joc.5b00455.

2014

64. Duckworth, B. P.; Wilson, D. J.; Aldrich, C. C.* Measurement of Nonribosomal Peptide Synthetase Adenylation Domain Activity Using a Continuous Hydroxylamine Release Assay. In Methods in Molecular Biology, Nonribosomal Peptide Synthetases, vol. x, Evans, B., Ed.; Humana Press: New York, NY, USA, 2014; in press.

63. Schiaffo, C.; Shi, C.; Xiong, Zhengmeng, Olin, M.; Aldrich, C. C.; Ferguson, D. M.* Structure Activity Relationship Analysis of Imidazoquinolines with Toll-Like Receptor 7 and 8 Selectivity and Enhanced Cytokine Induction. J. Med. Chem. 2014, 57, 339–347. DOI: 10.1021/jm4004957

62. Xu, Z.; Yin, W.; Martinelli, L.; Evans, J.; Chen, J.; Yu, Y.; Wilson, D. J.; Mizrahi, V.; Qiao, C.*; Aldrich, C. C.*Reaction Intermediate Analogues as Bisubstrate Inhibitors of Pantothenate Synthetase. Bioorg. Med. Chem.2014, 22, 1726–1735. DOI: 10.1016/j.bmc.2014.01.017

61. Dai, R.; Wilson, D. J.; Geders, T. W.; Aldrich, C. C.; Finzel, B. C.* Inhibition of Mycobacterium tuberculosisTransaminase BioA by Aryl Hydrazines and Hydrazides. ChemBioChem, 2014, 15, 575–586. DOI: 10.1002/cbic.20130074

2013

60. Kim, J-H.; O’Brien, K. M.; Sharma, R.; Boshoff, H. I.; Rehren, G.; Chakraborty, S.; Wallach, J. B.; Monteleone, M.; Wilson, D. J.; Aldrich, C. C.; Barry, C. E.; Rhee, K.; Ehrt, S.; Schnappinger, D.* A Novel Genetic Switch Identifies the Mycobacterium tuberculosis NAD Synthetase as a Target for the Development of Improved Tuberculosis Chemotherapies. Proc. Natl. Acad. Sci USA 2013, 110, 19095–19100. DOI:10.1073/pnas.1315860110

59. Shi, C.; Tiwari, D.; Wilson, D. J.; Seiler, C. L.; Schnappinger, D.; Aldrich, C. C.* Bisubstrate Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis Resistant to Cyclo-Nucleoside Formation. ACS Med. Chem. Lett. 2013, 4, 1213–1217. DOI: 10.1021/ml400328a

58. Meissner, A.; Boshoff, H. I.; Vasan, M.; Duckworth, B. P.; Barry, C. E. 3rd; Aldrich, C. C.* Structure-activitiy Relationships of 2-Aminothiazoles Effective Against Mycobacterium tuberculosis. Bioorg. Med. Chem. 2013, 21, 6385–6397. DOI: 10.1016/j.bmc.2013.08.048

57. Engellhart, C. A.; Aldrich, C. C. Synthesis of Chromone, Quinolone, and Benzoxazinone Sulfonamide Nucleosides as Conformationally Constrained Inhibitors of Adenylating Enzymes Required for Siderophore Biosynthesis. J. Org. Chem. 2013, 78, 7470–7481. DOI: 10.1021/jo400976f

56. Teitelbaum, A. M.; Meissner, A.; Wong, C. A.; Aldrich, C. C.*; Remmel, R. P.* Synthesis, pH-Dependent, and Plasma Stability of Meropenem Prodrugs for Drug-Resistant Tuberculosis. Bioorg. Med. Chem. 2013, 21, 5605–5617. DOI: 10.1016/j.bmc.2013.05.024

55. Neres, J.; Engelhart, C. A.; Drake, E. J.; Wilson, D. J.; Fu, P.; Boshoff, H. I.; Barry, C. E. 3rd; Gulick, A. M.;Aldrich, C. C.* Non-nucleoside Inhibitors of BasE, An Adenylating Enzyme in the Siderophore Biosynthetic Pathway of the Opportunistic Pathogen Acinetobacter baumannii. J. Med. Chem. 2013, 56, 2385–2405. DOI: 10.1021/jm301709s

54. Wilson, D. J.; Shi, C.; Teitelbaum, A. M.; Gulick, A. M.; Aldrich, C. C.* Characterization of AusA: A Dimodular Nonribosomal Peptide Synthetase Responsible for Production of Aureusimine Pyrazinones. Biochemistry 2013,52, 926–937. DOI: 10.1021/bi301330q

53. Zhang, K.; Nelson, K. M.; Bhuripanyo, K.; Grimes, K. D.; Zhao, B.; Aldrich, C. C.*; Yin, J.* Engineering the Substrate Specificity of the DhbE Adenylation Domain by Yeast Cell Surface Display Chem. Biol. 2013, 20, 92–101. DOI: 10.1016/j.chembiol.2012.10.020

2012

52. Duckworth, B. P.; Nelson, K.; Boshoff, H. I.; Barry, C. E.3rd; Aldrich, C. C.* Development of a Selective Activity Based Probe for Adenylating Enzymes (AEs): Profiling MbtA Involved in Siderophore Biosynthesis fromMycobacterium tuberculosis. ACS Chem. Biol. 2012, 7, 1653–1658. DOI: 10.1021/cb300112x

51. Shi, C.; Aldrich, C. C.* Synthesis of Mechanism-Based Inhibitors of the Aminotransferase BioA Involved in Biotin Biosynthesis as Potential Antibacterial Agents. J. Org. Chem. 2012, 77, 6051–6058. DOI: 10.1021/jo3008435

50. Martinelli, L. K.; Aldrich, C. C.* Antimetabolite Poisoning of Cofactor Biosynthesis. Chem. Biol. 2012, 19, 543–544. DOI: 10.1016/j.chembiol.2012.05.004

49. Shi, C.; Xiong, Z.; Chittepu, P.; Aldrich, C. C.; Ohlfest, J. R.; Ferguson, D. M.* Discovery of Human Toll-like Receptor 7/8-Active Imidazoquinoline Analogs with Novel Cytokine Induction. ACS Med. Chem. Lett. 2012, 3,501–504. DOI: 10.1021/ml300079e

48. Nelson, K. M.; Salomon, C. E.; Aldrich, C. C.* Total Synthesis and Biological Evaluation of Transvalencin Z.J. Nat. Prod. 2012, 75, 1037–1043. DOI: 10.1021/np200972s

47. Mitchell, C. A.; Shi, C.; Aldrich, C. C.; Gulick, A. M.* The Structure of PA1221, a Non-Ribosomal Peptide Synthetase containing Adenylation and Peptidyl Carrier Protein Domains. Biochemistry 2012, 51, 3252–3263. DOI: 10.1021/bi300112e

46. Duckworth, B. P.; Nelson, K. M.; Aldrich, C. C.* Adenylating Enzymes in Mycobacterium tuberculosis as Drug Targets. Curr. Top. Med. Chem. 2012, 12, 766–796. DOI: 10.2174/156802612799984571

45. Sundlov, J.; Shi, C.; Wilson, D. J.; Aldrich, C. C.; Gulick, A. M.* Structural and Functional Investigation of the Intermolecular Interaction Between the EntE Adenylation Domain and its Cognate Carrier Protein EntB. Chem. Biol. 2012, 19, 188–198. DOI: 10.1016/j.chembiol.2011.11.013

44. Kalinda, A.; Aldrich, C. C.* Pyrazinamide: A Frontline Drug Used for Tuberculosis. Molecular Mechanism of Action Resolved after 50 Years? Chemmedchem 2012, 7, 558–560. DOI: 10.1002/cmdc.201100587.

2011

43. Duckworth, B. P.; Geders, T. W.; Tiwari, D.; Boshoff, H. I.; Sibbald, P. A.; Barry, C. E. 3rd; Schnappinger, D.; Finzel, B. C.; Aldrich, C. C.* Inhibition of Biotin Protein Ligase from Mycobacterium tuberculosis. Chem. Biol.2011, 18, 1432–1441. DOI: 10.1016/j.chembiol.2011.08.013

42. Shi, C.; Geders, T. W.; Park, S. W.; Wilson, D. J.; Boshoff, H. I.; Barry, C. E. 3rd; Schnappinger, D.; Finzel, B. C.; Aldrich, C. C.* Mechanism-Based Inactivation by Aromatization of the Transaminase BioA Involved in Biotin Biosynthesis in Mycobacterium tuberculosis. J. Am. Chem. Soc. 2011, 133, 18194–18201. DOI: 10.1021/ja204036t

41. Park, S. W.; Klotzsche, M.; Wilson, D. J.; Boshoff, H. I.; Eoh, H.; Manjunatha, U.; Blumenthal, A.; Rhee, K.; Barry, C. E. 3rd; Aldrich, C. C.; Ehrt, S.*; Schnappinger, D.* Evaluating the Sensitivity of Mycobacterium tuberculosis to Biotin Deprivation Using Regulated Gene Expression. PloS Pathogens. 2011, 7, e1002264. DOI:10.1371/journal.ppat.1002264

40. Grimes, K. D.; Aldrich, C. C.* A High-throughput Screening Fluorescence Polarization Assay for the Fatty Acid Adenylating Enzyme FadD28 in Mycobacterium tuberculosis. Analytical Biochem. 2011, 417, 264–273. DOI:10.1016/j.ab.2011.06.037

39. Wilson, D. J.; Shi, C.; Duckworth, B. P.; Murtta, J. M.; Sham, Y. Y.; Thomas, D. D.; Aldrich, C. C.* A Continuous Fluorescence Displacement Assay for BioA: An Enzyme Involved in Biotin Biosynthesis. Analytical Biochem. 2011, 416, 27–38. DOI: 10.1016/j.ab.2011.05.003

38. Duckworth, B. P.; Boshoff, H. I.; Barry, C. E. 3rd; Aldrich, C. C.* Design of a Nucleoside Inhibitor of Biotin Protein Ligase from Mycobacterium tuberculosis, In Collection Symposium Series, XIVth Symposium on Chemistry of Nucleic Acid Components, Cesky Krumlov, Czech Republic, June 5–10, 2011; Hocek, M. Ed.; Vol. 12; Academy of Sciences of the Czech Republic: Prague, 2011; pp 199–203.

2010

37. Vasan, M.; Neres, J.; Williams, J.; Wilson, D. J.; Teitelbaum, A. M.; Remmel, R. P.; Aldrich, C. C.* Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High-Throughput Screening.Chemmedchem, 2010, 5, 2079–2087. DOI: 10.1002/cmdc.201000275

36. Duckworth, B. P.; Aldrich, C. C.* Assigning Enzyme Function from the Metabolic Milieu. Chem. Biol. 2010,17, 313–314. DOI: 10.1016/j.chembiol.2010.04.001

35. Drake, E. J.; Duckworth, B. P.; Neres, J.; Aldrich, C. C.; Gulick, A. M.* Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Non-ribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis. Biochemistry, 2010, 49, 9292–9305. DOI: 10.1021/bi101226n

34. Wilson, D. J.; Aldrich, C. C.* A Continuous Kinetic Assay for Adenylation Enzyme Activity and Inhibition.Analytical Biochem. 2010, 404, 56–63. DOI: 10.1016/j.ab.2010.04.033

33. Chen, L.*; Wilson, D. J.; Xu, Y.; Aldrich, C. C.; Felczak, K.; Sham, Y. Y.; Pankiewicz, K. W. Triazole-linked Inhibitors of Inosine Monophosphate Dehydrogenase from Human and Mycobacterium tuberculosis. J. Med. Chem. 2010, 53, 4768–4778. DOI: 10.1021/jm100424m

32. Duckworth, B. P.; Aldrich, C. C.* Development of a High-Throughput Fluorescence Polarization Assay for the Discovery of Phosphopantetheinyl Transferase Inhibitors. Analytical Biochem. 2010, 403, 13–19. DOI: 10.1016/j.ab.2010.04.009

31. Shi, C.; Aldrich, C. C.* Efficient Pd-Catalyzed Coupling of Tautomerizable Heterocycles with Terminal Alkynes via C-OH Bond Activation Using PyBroP. Org. Lett. 2010, 12, 2286–2289. DOI: 10.1021/ol100657n

30. Sikora, A. L.; Wilson, D. J.; Aldrich, C. C.; Blanchard, J. S.* Kinetic and Inhibition Studies of Dihydroxybenzoate-AMP Ligase (EntE) from Escherichia coli. Biochemistry 2010, 49, 3648–3657. DOI: 10.1021/bi100350c

29. Grimes, K. D.; Gupte, A.; Aldrich, C. C.* Copper(II)-Catalyzed Conversion of Aryl/Heteroaryl Boronic acids, -Boronates, and –Trifluoroboronates to the Corresponding Azides: Substrate Scope and Limitations. Synthesis2010, 1441–1448. DOI: 10.1055/s-0029-1218683

28. Aldrich, C. C.; Boshoff, H. I.; Remmel, R. P. Antitubercular Agents. In Burgers Medicinal Chemistry, 7thEdition; Eds. Rotella, D.; Abraham, D. J.; Wiley, 2010; 713–812.

2009

27. Schneider, P.; Jacobs, J. M.; Neres, J.; Aldrich, C. C.; Allen, C.; Nett, M.; Hoffmeister, D.* The Global Virulence Regulators VsrAD and PhcA Control Secondary Metabolism in the Plant Pathogen Ralstonia solanacearum. Chembiochem 2009, 10, 2730–2732. DOI: 10.1002/cbic.200900510

26. Misiek, M.; Williams, J.; Schmich, K.; Hüttel, W.; Merfort, I.; Salomon, C. E.; Aldrich, C. C.; Hoffmeister, D.* Structure and cytotoxicity of Arnamial and Related Fungal Sesquiterpene Aryl Esters. J. Nat. Prod. 2009, 72, 1888–1891. DOI: 10.1021/np900314p

25. Petrelli, R.; Sham, Y. Y.; Chen, L.; Felczak, K.; Bennett, E.; Wilson, D. J.; Aldrich, C. C.; Yu, J. S.; Cappellacci, L.; Franchetti, P.; Grifantini, M.; Mazzola, F.; Di Stefano, M.; Magni, G.; Pankiewicz, K. W.* Selective Inhibition of NAD Kinases by Dinucleoside Disulfide NAD Mimics of NAD Analogues. Bioorg. Med. Chem. 2009,17, 5656–5664. DOI: 10.1016/j.bmc.2009.06.013

2008

24. Gupte, A.; Boshoff, H. I.; Wilson, D. J.; Neres, J.; Labello, N. P.; Somu, R. V.; Xing, C.; Barry, C. E. 3rd;Aldrich, C. C.* 2-Triazole Substituted Analogues of 5’-O-[N-(Salicyl)sulfamoyl]-adenosine: Antibacterial Nucleosides Effective Against Mycobacterium tuberculosis. J. Med. Chem. 2008, 51, 7495–7507. DOI: 10.1021/jm8008037

23. Labello, N. P.; Neres, J. Bennett, E. M.; Ferguson, D. M.*; Aldrich, C. C. Quantitative Three Dimensional Structure Linear Interaction Energy Model of 5’-O-[N-(Salicyl)sulfamoyl]adenosine and the Aryl Acid Adenylating Enzyme MbtA. J. Med. Chem. 2008, 51, 7154–7160. DOI: 10.1021/jm800668u

22. Neres, J.; Wilson, D. J.; Celia, L.; Beck, B. J.; Aldrich, C. C.* Aryl Acid Adenylating Enzymes (AAAE) Involved in Siderophore Biosynthesis: Development of a Fluorescence Polarization Assay, Determination of AAAE Ligand Specificity, and Discovery of Non-nucleoside Inhibitors. Biochemistry, 2008, 47, 11735–11749. DOI: 10.1021/bi801625b

21. Neres, J.; Labello, N. P.; Somu, R. V.; Boshoff, H. I.; Wilson, D. J.; Vannada, J.; Chen, L.; Barry, C. E. 3rd; Bennett, E. M.; Aldrich, C. C.* Inhibition of Siderophore Biosynthesis in Mycobacterium tuberculosis with Nucleoside Bisubstrate Analogues: Structure Activity Relationships of the Nucleobase Domain of 5’-O-[N-(Salicyl)sulfamoyl]adenosine. J. Med. Chem. 2008, 51, 5349–5370. DOI: 10.1021/jm800567v

20. Aldrich, C. C.; Somu, R. V. Nucleoside Antibiotics as Antitubercular Agents. In Nucleosides in Biochemistry, Biotechnology and Medicine; Herdewijn, P., Ed.; Wiley: Weinheim, Germany, 2008; 365–391.

19. Gupte, A.; Subramanian, M.; Remmel, R. P.; Aldrich, C. C.* Synthesis of Deuterium-labelled 5’-O-[N-(Salicyl)sulfamoyl]adenosine (Sal-AMS-d4) as an Internal Standard for Quantitation of Sal-AMS. J. Label. Compd. Radiopharm. 2008, 51, 118–122. DOI: 10.1002/jlcr.1490

2007

18. Qiao, C.; Gupte, A.; Boshoff, H. I.; Wilson, D. J.; Bennett, E. M.; Somu, R. V.; Barry, C. E. III.; Aldrich, C. C. *5’-O-[(N-Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Aryl Adenylating Enzyme Required for Siderophore Biosynthesis of the Mycobactins. J. Med. Chem. 2007, 50, 6080–6094. DOI: 10.1021/jm070905o

17. Qiao, C.; Wilson, D. J.; Bennett, E. M.; Aldrich, C. C.* A Mechanism-Based Aryl Carrier Protein/Thiolation Domain Affinity Probe. J. Am. Chem. Soc. 2007, 129. 6350–6351. DOI: 10.1021/ja069201e

16. Pfleger, B. F.; Lee, J. Y.; Somu, R. V.; Aldrich, C. C.; Hanna, P. C.; Sherman, D. H.* Characterization and Analysis of Early Enzymes for Petrobactin Biosynthesis in Bacillus anthracis. Biochemistry, 2007, 46, 4147–4157. DOI: 10.1021/bi6023995

15. Lee, J. Y.; Janes, B. K.; Passalacqua, K. D.; Pfleger, B. F.; Bergman, N. H.; Liu, H.; Håkansson, K.; Somu, R. V.; Aldrich, C. C.; Cendrowski, S.; Hanna, P.; Sherman, D. H.* Biosynthetic Analysis of the Petrobactin Siderophore Pathway from Bacillus anthracis. J. Bacteriol. 2007, 189, 1698–1710. DOI:10.1128/JB.01526-06

2006

14. Somu, R. V.; Wilson, D. J.; Bennett, E. M.; Boshoff, H. I.; Celia, L.; Beck, B. J.; Barry, C. E. 3rd; Aldrich. C. C.*Antitubercular Nucleosides that Inhibit Siderophore Biosynthesis: SAR of the Glycosyl Domain. J. Med. Chem.2006, 49, 7623–7635. DOI: 10.1021/jm061068d

13. Vannada, J.; Bennett, E. M.; Wilson, D. J.; Boshoff, H. I.; Barry, C. E. 3rd; Aldrich, C. C.* Design, Synthesis and Biological Evaluation of b-Ketosulfonamide Adenylation Inhibitors as Potential Antitubercular Agents. Org. Lett. 2006, 8, 4707–4711. DOI: 10.1021/ol0617289

12. Somu, R. V.; Boshoff, H.; Qiao, C.; Bennett, E. M.; Barry, C. E. 3rd; Aldrich, C. C.* Rationally Designed Nucleoside Antibiotics That Inhibit Siderophore Biosynthesis of Mycobacterium tuberculosis. J. Med. Chem.2006, 49, 31–34. DOI: 10.1021/jm051060o

Dr. Aldrich's Post-Doctoral and Graduate Work

11. Beck, Z. Q.; Aldrich, C. C.; Magarvey, N.; Georg, G. I.; Sherman, D. H. A Chemoenzymatic Synthesis of Cryptophycin/Arenastatin Natural Products. Biochemistry 2005, 44, 13457–13466. DOI: 10.1021/bi051140u

10. Lakshmanan, V.; Aldrich, C. C.; Sherman, D. H.; Fecik, R. A. Formal Total Synthesis of the Polyketide Macrolactone Narbonolide. J. Org. Chem. 2005, 70, 7267–7272. DOI: 10.1021/jo050924a

9. Aldrich, C. C.; Fecik, R. A.; Lakshmanan, V. Sherman, D. H. Chemoenzymatic Synthesis of the Polyketide Macrolactone 10-Deoxymethynolide. J. Am. Chem. Soc. 2005, 127, 8910–8911. DOI: 10.1021/ja0504340

8. Aldrich, C. C.; Beck, B. J.; Fecik, R. A.; Sherman, D. H. Biochemical Investigation of Pikromycin Biosynthesis Employing Native Penta- and Hexaketide Chain Elongation Intermediates. J. Am. Chem. Soc. 2005,127, 8441–8452. DOI: 10.1021/ja042592h

7. Nishizawa, T.; Aldrich, C. C.; Sherman, D. H. Molecular Analysis of the Rebeccamycin L-Amino Acid Oxidase from Lechevalieria aerocolonigenes ATCC 39243. J. Bacteriol. 2005, 187, 2084–2092.DOI: 10.1128/JB.187.6.2084-2092.2005

6. Soulere, L; Aldrich C.; Daumke, O.; Gail, R.; Kissau, L.; Wittinghofer, A.; Waldmann, H. Synthesis of GTP-Derived Ras Ligands. Chembiochem 2004, 5, 1448–1453. DOI: 10.1002/cbic.200400133

5. Beck, B. J.; Aldrich, C. C.; Fecik, R. A.; Reynolds, K. A.; Sherman, D. H. Substrate Recognition and Channeling of Monomodules from the Pikromycin Polyketide Synthase. J. Am. Chem. Soc. 2003, 125, 12551–12557. DOI: 10.1021/ja034841s

4. Beck, B. J.; Aldrich, C. C.; Fecik, R. A.; Reynolds, K. A.; Sherman, D. H. Iterative Chain Elongation by a Pikromycin Monomodular Polyketide Synthase. J. Am. Chem. Soc. 2003, 125, 4682–4683. DOI: 10.1021/ja029974c

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