11:00am – 12:00pm Registration

12:00pm – 1:00pm Lunch

1:00pm – 1:15pm Welcome

1:15pm – 3:15pm Session I – DNA Repair Pathways in Genome Maintenance and Diversification

1:15pm – 2:00pm Keynote talk: Dale Ramsden, University of North Carolina

End joining repair of chromosome breaks

2:00pm – 2:15pm Benjamin Stinson, Dana-Farber Cancer Institute

A mechanism to minimize errors during non-homologous end joining

2:15pm – 2:30pm McKenna DeFoer, University of Michigan Medical School

Reduced expression of Mre11 results in impaired lymphocyte development and anemia

2:30pm – 2:45pm Richard Frock, Stanford University School of Medicine

Parallel DNA joint capture identifies recombination and DNA end tethering regulators

2:45pm – 3:00pm Carter Wheat, The Ohio State University

Cryo-EM structures of yeast RAD52 homolog Mgm101 in complex with DNA reveal snapshots of a full single-strand annealing pathway

3:00pm – 3:15pm Peyton Oden, University of Kansas Medical Center

Visualizing APE1 DNA damage search and recognition mechanisms using CTFM

3:15pm – 3:45pm Coffee break

3:45pm – 5:45pm Session II – Genome Instability: Tools and Technologies

3:45pm – 4:30pm Keynote talk: Valerie Borde, Institute Curie

Recombination laid bare: single molecule analyses reveal hidden properties of meiotic recombination

4:30pm – 4:45pm William Cvammen, University of Pittsburgh

Trabectedin and lurbinectedin disrupt transcription-coupled nucleotide excision repair, leading to DNA breaks in actively transcribed genes

4:45pm – 5:00pm Shelby Hemker, University of Michigan Medical School

A DNA repair-reporter deep mutational scan comprehensively maps missense effects in the glycosylase MUTYH

5:00pm – 5:15pm Yangwode (Wode) Jing, Princeton University

Identifying pathway-specific inhibitors of DNA mismatch repair 

5:15pm – 5:30pm Tomáš Janovič, Michigan State University

TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres

5:30pm – 5:45pm Taiwo Akinyemi, Integrated DNA Technologies

Synthetic biology solutions for DNA repair studies

5:45pm – 7:00pm Dinner

7:00pm – 9:00pm Poster session

7:30am – 8:30am Breakfast

8:30am – 10:30am Session III – DNA Repair and Disease

8:30am – 9:15am Keynote talk: Patrick Sung, UT Health San Antonio

DNA damage repair via the BRCA axis

9:15am – 9:30am Istri Ndoja, Wayne State University School of Medicine

Utilizing novel combination therapies in NSCLC based with DNA repair and p53 deficiencies to induce platinum sensitivity

9:30am – 9:45am Ziqing Zhu, Rogel Cancer Center, University of Michigan Medical School

Investigating how Sam68 arginine methylation regulates DNA repair in glioblastoma

9:45am – 10:00am   Lindsey Aubuchon, Washington University in St. Louis

Targeting ALC1 ATPase activity as a new synthetic lethal strategy in BRCA-mutant cancer

10:00am – 10:15am   Ryan Barnes, University of Kansas Cancer Center

Oxidative base damage to telomeres sensitizes cancer cells to ATR inhibition

10:15am – 10:30am   Marta Markiewicz-Potoczny, University of Illinois at Chicago

Nonsense-mediated mRNA decay (NMD) and its novel role in telomere protection of pluripotent stem cells

10:30am – 11:00am Coffee break

11:00am – 12:30pm Session IV – DNA Recombination Proteins in Meiosis and Replication

11:00am – 11:45am     Keynote talk: Doug Bishop, University of Chicago

Mechanisms of Dmc1 regulation

11:45am – 12:00pm    Jesus Monge Neria, Cleveland State University

Synaptonemal complex-dependent modulation of Rad51 and Dmc1 strand exchange governs meiotic crossover pathway divergence

12:00pm – 12:15pm   Zane Tolbert, Clemson University

Nascent strand degradation and genomic instability in FANCD2 and FANCA deficient cells requires RAD54L-mediated fork reversal

12:15pm – 12:30pm   Isabelle Seppa, Washington University in St. Louis

Mechanisms of ssDNA gap resection in BRCA1-proficient and -deficient cells

12:30pm – 1:00pm Awards

1:00pm Lunch & Adjourn