Embedded Files
Practice
Knowledge
Named Reactions in Synthesis (Kürti)
Logic of Chemical Synthesis (Corey)
Top 200 Drugs (Njardarson)
Not Voodoo (Frontier)
Selected Required Reading (i.e. The Classics)
Broader Chemistry Perspectives
Top Heterocycles in FDA-Approved Drugs (Njardarson, J. Med. Chem. 2024 11622) – Original 2014
Application of Small Aliphatic Rings in Medicinal Chemistry (RSC Med. Chem. 2021 448)
Common Functional Groups in Bioactive Molecules (Ertl J. Med. Chem. 2020 8408)
Where Have All the New Reactions Gone? (Brown, J. Med. Chem. 2016 4443)
Aiming for the Ideal Synthesis (Baran, J. Org. Chem. 2010 4657)
Escape from Flatland (Lovering, J. Med. Chem. 2009 6752)
Transformative Modern Methodology
MacMillan Deoxygenative Coupling (Nature 2021 451)
Buchwald-Hartwig Amination (Org. Process Res. Dev. 2019 1478)
Universal Suzuki-Miyaura Cross Coupling (ACIE 2004 1871)
Groundbreaking Total Synthesis
Process Manufacture:
Total Synthesis of Enlicitide Decanoate (Merck Process, JACS 2025 11036).
Biocatalytic Cascade for the Manufacture of Islatravir (Merck Process, Science 2019 1255)
Total Synthesis of Eribulin Mesylate (Eisai, Nat. Prod. Rep. 2013 1153)
Natural Products:
Total Synthesis of Type I Polyketides (Krische, Chem. Rev. 2024 13715)
Total Synthesis of Taxol (Nicolaou, Nature 1994 630)
Total Synthesis of Vitamin B12: Woodward (PAC 1973 145) & Eschenmoser (Science 1977 1410)
Machine-Learning Feats
Generative Reaction Mechanism Prediction (Coley, Nature 2025 115)
Highly Accurate Protein Structure Prediction with AlphaFold (DeepMind, Nature 2021 583)
GNNs for the Prediction of Chemical Reactivity (Jensen, Chem. Sci. 2019 370)
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