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Our research encompasses both human participant research and translational laboratory modeling approaches. We focus on mechanisms and biomarkers of food allergy/anaphylaxis and atopic dermatitis. Our team integrates their diverse sets of expertise in human sampling and anaphylaxis pathogenesis with specific modeling techniques to outline and then define new mechanisms in early anaphylaxis propagation and food allergy development.
Laboratory Studies
Laboratory Studies
Models of Allergic Disease - Food Allergy
Models of Allergic Disease - Food Allergy
Our laboratory uses in vitro and in vivo models of mast cell degranulation and food anaphylaxis to study the early phases of anaphylaxis propagation and its connections to epithelial barrier function. Each of the human subjects studies below contribute to these efforts such that the two areas are deeply interconnected. We have several targets and techniques that we hope to share in the near future via publication on these topics.
Human Subjects Studies
Human Subjects Studies
FAB (Food Allergy Biomarkers) Study
FAB (Food Allergy Biomarkers) Study
This study seeks to identify novel biomarkers and mechanisms of food anaphylaxis. This is an observational and bio-sampling study of patients undergoing oral food challenges during routine clinical care or on research protocols for clinical trials.
This clinical trial is investigating whether transepidermal (across the skin) water loss can be deployed as a predictive marker for allergic reactions during oral food challenges to reduce reaction severity. This study is registered with clinicaltrials.gov and can be found at umhealthresearch.org. This study is no longer enrolling.
M-FAD (Michigan Food Allergy and atopic Dermatitis) Study
M-FAD (Michigan Food Allergy and atopic Dermatitis) Study
This basic study in humans is taking an intensive multi-omics approach to better define the genetic overlap between food allergy and atopic dermatitis as well as defining new pathways of anaphylaxis propagation and its relationship to the cutaneous epithelial barrier. This is an exciting collaboration between the University of Michigan Food Allergy Center and the Department of Dermatology. This study is actively enrolling.
Funding Sources
Funding Sources
We wish to thank and acknowledge our past and present financial and non-financial support. This includes the following external sources:
NIH/NIAID: 1K23AI162661 and 1U01AI181882
Gerber Foundation: Research Award #9026
Courage + Khazaka gmbh (material, non-financial support)
This also includes the following institutional sources:
Mary H. Weiser Food Allergy Center: M-FARA pilot award
Department of Internal Medicine: Ronald Koenig, MD, PhD Early Career Endowment Award
MICHR: CTSA 5UM1TR004404 and Catalyst pilot grant program
To learn more about opportunities to enroll in clinical research for food allergy, contact foodallergyclinicalresearch@med.umich.edu.
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