Publications

2020

Ding N, Harlow SD, Randolph JF Jr, Loch-Caruso R, Park SK. Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary. Hum Reprod Update. 2020 Sep 1;26(5):724-752. doi: 10.1093/humupd/dmaa018. PubMed PMID: 32476019; PubMed Central PMCID: PMC7456353.

Loch-Caruso R, Korte CS, Hogan KA, Liao S, Harris C. Tert-Butyl Hydroperoxide Stimulated Apoptosis Independent of Prostaglandin E2 and IL-6 in the HTR-8/SVneo Human Placental Cell Line. Reprod Sci. 2020 Nov;27(11):2104-2114. doi: 10.1007/s43032-020-00231-5. Epub 2020 Jun 15. PubMed PMID: 32542535; PubMed Central PMCID: PMC7529854.

Harris SM, Boldenow E, Domino SE, Loch-Caruso R. Toxicant Disruption of Immune Defenses: Potential Implications for Fetal Membranes and Pregnancy. Front Physiol. 2020;11:565. doi: 10.3389/fphys.2020.00565. eCollection 2020. PubMed PMID: 32547423; PubMed Central PMCID: PMC7272693.

Park HR, Elkin ER, Castillo-Castrejon M, Loch-Caruso R. Brominated diphenyl ether-47 differentially regulates cellular migration and invasion in a human first trimester trophoblast cell line. Reprod Toxicol. 2020 Apr;93:191-198. doi: 10.1016/j.reprotox.2020.02.014. Epub 2020 Mar 3. PubMed PMID: 32142752; PubMed Central PMCID: PMC7254746.

Harris SM, Jin Y, Loch-Caruso R, Padilla IY, Meeker JD, Bakulski KM. Identification of environmental chemicals targeting miscarriage genes and pathways using the comparative toxicogenomics database. Environ Res. 2020 May;184:109259. doi: 10.1016/j.envres.2020.109259. Epub 2020 Feb 19. PubMed PMID: 32143025; PubMed Central PMCID: PMC7103533.

Elkin ER, Harris SM, Su AL, Lash LH, Loch-Caruso R. Placenta as a target of trichloroethylene toxicity. Environ Sci Process Impacts. 2020 Mar 1;22(3):472-486. doi: 10.1039/c9em00537d. Epub 2020 Feb 5. PubMed PMID: 32022077; PubMed Central PMCID: PMC7103546.

Elkin ER, Bridges D, Harris SM, Loch-Caruso RK. Exposure to Trichloroethylene Metabolite S-(1,2- Dichlorovinyl)-L-cysteine Causes Compensatory Changes to Macronutrient Utilization and Energy Metabolism in Placental HTR-8/SVneo Cells. Chem Res Toxicol. 2020 Jun 15;33(6):1339-1355. doi: 10.1021/acs.chemrestox.9b00356. Epub 2020 Jan 30. PubMed PMID: 31951115; PubMed Central PMCID: PMC7299793.

Su AL, Loch-Caruso R (2020) Comparison of Rat Fetal Sex Determination Using Placental gDNA and mRNA via qRT-PCR. J Mol Biol Methods 3:2. doi: 10.37532/jmbm.2020.3(1).107. PMCID: PMC7665159.

2019

Aker A, McConnell RER, Loch-Caruso R, Park SK, Mukherjee B, Rosario ZY, Vélez-Vega CM, HuertaMontanez G, Alshawabkeh AN, Cordero JF, Meeker JD. Interactions between chemicals and nonchemical stressors: The modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort. Sci Total Environ. 2020 Mar 15;708:134719. doi: 10.1016/j.scitotenv.2019.134719. Epub 2019 Oct 31. PubMed PMID: 31785910; PubMed Central PMCID: PMC6957748.

Elkin ER, Bridges D, Loch-Caruso R. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine induces progressive mitochondrial dysfunction in HTR-8/SVneo trophoblasts. Toxicology. 2019 Nov 1;427:152283. doi: 10.1016/j.tox.2019.152283. Epub 2019 Aug 30. PubMed PMID: 31476333; PubMed Central PMCID: PMC6943978

2018

Loch-Caruso R, Hassan I, Harris SM, Kumar A, Bjork F, Lash LH. Trichloroethylene exposure in midpregnancy decreased fetal weight and increased placental markers of oxidative stress in rats. Reprod Toxicol. 2019 Jan;83:38-45. doi: 10.1016/j.reprotox.2018.11.002. Epub 2018 Nov 20. PubMed PMID: 30468822; PubMed Central PMCID: PMC6404769.

Aung MT, Ferguson KK, Cantonwine DE, Bakulski KM, Mukherjee B, Loch-Caruso R, McElrath TF, Meeker JD. Associations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy: A repeated measures study. Sci Total Environ. 2019 Feb 10;650(Pt 1):1131-1140. doi: 10.1016/j.scitotenv.2018.08.356. Epub 2018 Aug 29. PubMed PMID: 30308801; PubMed Central PMCID: PMC6236678.

Koman PD, Hogan KA, Sampson N, Mandell R, Coombe CM, Tetteh MM, Hill-Ashford YR, Wilkins D, Zlatnik MG, Loch-Caruso R, Schulz AJ, Woodruff TJ. Examining Joint Effects of Air Pollution Exposure and Social Determinants of Health in Defining "At-Risk" Populations Under the Clean Air Act: Susceptibility of Pregnant Women to Hypertensive Disorders of Pregnancy. World Med Health Policy. 2018 Mar;10(1):7-54. doi: 10.1002/wmh3.257. Epub 2018 Mar 12. PubMed PMID: 30197817; PubMed Central PMCID: PMC6126379.

Park HR, Harris SM, Boldenow E, McEachin RC, Sartor M, Chames M, Loch-Caruso R. Group B streptococcus activates transcriptomic pathways related to premature birth in human extraplacental membranes in vitro. Biol Reprod. 2018 Mar 1;98(3):396-407. doi: 10.1093/biolre/iox147. PubMed PMID: 29155939; PubMed Central PMCID: PMC6248496.

2017

Elkin ER, Harris SM, Loch-Caruso R. Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a firsttrimester placental cell line. Toxicol Appl Pharmacol. 2018 Jan 1;338:30-42. doi: 10.1016/j.taap.2017.11.006. Epub 2017 Nov 10. PubMed PMID: 29129777; PubMed Central PMCID: PMC5741094.

2016

Hassan I, Kumar AM, Park HR, Lash LH, Loch-Caruso R. Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2- Dichloro)-l-Cysteine. Biol Reprod. 2016 Sep;95(3):66. doi: 10.1095/biolreprod.116.139261. Epub 2016 Aug 3. PubMed PMID: 27488030; PubMed Central PMCID: PMC5394980.

2015

Ferguson KK, McElrath TF, Mukherjee B, Loch-Caruso R, Meeker JD. Associations between Maternal Biomarkers of Phthalate Exposure and Inflammation Using Repeated Measurements across Pregnancy. PLoS One. 2015;10(8):e0135601. doi: 10.1371/journal.pone.0135601. eCollection 2015. PubMed PMID: 26317519; PubMed Central PMCID: PMC4552851.

Tetz LM, Aronoff DM, Loch-Caruso R. Mono-ethylhexyl phthalate stimulates prostaglandin secretion in human placental macrophages and THP-1 cells. Reprod Biol Endocrinol. 2015 Jun 3;13:56. doi: 10.1186/s12958-015-0046-8. PubMed PMID: 26036283; PubMed Central PMCID: PMC4462084.

Park HR, Loch-Caruso R. Protective effect of (±)α-tocopherol on brominated diphenyl ether-47-stimulated prostaglandin pathways in human extravillous trophoblasts in vitro. Toxicol In Vitro. 2015 Oct;29(7):1309-18. doi: 10.1016/j.tiv.2015.05.015. Epub 2015 May 27. PubMed PMID: 26026498; PubMed Central PMCID: PMC4553091.

Boldenow E, Hassan I, Chames MC, Xi C, Loch-Caruso R. The trichloroethylene metabolite S-(1,2- dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro. Reprod Toxicol. 2015 Apr;52:1-6. doi: 10.1016/j.reprotox.2015.01.007. Epub 2015 Jan 31. PubMed PMID: 25653212; PubMed Central PMCID: PMC4426062.

2014

Park HR, Kamau PW, Korte C, Loch-Caruso R. Tetrabromobisphenol A activates inflammatory pathways in human first trimester extravillous trophoblasts in vitro. Reprod Toxicol. 2014 Dec;50:154-62. doi: 10.1016/j.reprotox.2014.10.005. Epub 2014 Oct 17. PubMed PMID: 25461914; PubMed Central PMCID: PMC4260776.

Park HR, Loch-Caruso R. Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line. Toxicol Appl Pharmacol. 2014 Nov 15;281(1):67-77. doi: 10.1016/j.taap.2014.09.015. Epub 2014 Oct 11. PubMed PMID: 25305463; PubMed Central PMCID: PMC4393751

Boldenow E, Hogan KA, Chames MC, Aronoff DM, Xi C, Loch-Caruso R. Role of cytokine signaling in group B Streptococcus-stimulated expression of human beta defensin-2 in human extraplacental membranes. Am J Reprod Immunol. 2015 Mar;73(3):263-72. doi: 10.1111/aji.12325. Epub 2014 Sep 29. PubMed PMID: 25263616; PubMed Central PMCID: PMC4323989.

Korir ML, Knupp D, LeMerise K, Boldenow E, Loch-Caruso R, Aronoff DM, Manning SD. Association and virulence gene expression vary among serotype III group B streptococcus isolates following exposure to decidual and lung epithelial cells. Infect Immun. 2014 Nov;82(11):4587-95. doi: 10.1128/IAI.02181-14. Epub 2014 Aug 18. PubMed PMID: 25135682; PubMed Central PMCID: PMC4249324.

Ferguson KK, McElrath TF, Chen YH, Loch-Caruso R, Mukherjee B, Meeker JD. Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. Am J Obstet Gynecol. 2015 Feb;212(2):208.e1-8. doi: 10.1016/j.ajog.2014.08.007. Epub 2014 Aug 8. PubMed PMID: 25111586; PubMed Central PMCID: PMC4312513.

Ferguson KK, Cantonwine DE, Rivera-González LO, Loch-Caruso R, Mukherjee B, Anzalota Del Toro LV, Jiménez-Vélez B, Calafat AM, Ye X, Alshawabkeh AN, Cordero JF, Meeker JD. Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in Puerto Rico. Environ Sci Technol. 2014 Jun 17;48(12):7018-25. doi: 10.1021/es502076j. Epub 2014 Jun 6. PubMed PMID: 24845688; PubMed Central PMCID: PMC4066910.

2013

Park HR, Kamau PW, Loch-Caruso R. Involvement of reactive oxygen species in brominated diphenyl ether-47-induced inflammatory cytokine release from human extravillous trophoblasts in vitro. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):283-92. doi: 10.1016/j.taap.2013.11.015. Epub 2013 Dec 1. PubMed PMID: 24296301; PubMed Central PMCID: PMC3931445.

Boldenow E, Jones S, Lieberman RW, Chames MC, Aronoff DM, Xi C, Loch-Caruso R. Antimicrobial peptide response to group B Streptococcus in human extraplacental membranes in culture. Placenta. 2013 Jun;34(6):480-5. doi: 10.1016/j.placenta.2013.02.010. Epub 2013 Apr 2. PubMed PMID: 23562109; PubMed Central PMCID: PMC3664555.

Tetz LM, Kamau PW, Cheng AA, Meeker JD, Loch-Caruso R. Troubleshooting the dichlorofluorescein assay to avoid artifacts in measurement of toxicant-stimulated cellular production of reactive oxidant species. J Pharmacol Toxicol Methods. 2013 Mar-Apr;67(2):56-60. doi: 10.1016/j.vascn.2013.01.195. Epub 2013 Feb 4. PubMed PMID: 23380227; PubMed Central PMCID: PMC3795613.

Tetz LM, Cheng AA, Korte CS, Giese RW, Wang P, Harris C, Meeker JD, Loch-Caruso R. Mono-2- ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro. Toxicol Appl Pharmacol. 2013 Apr 1;268(1):47-54. doi: 10.1016/j.taap.2013.01.020. Epub 2013 Jan 27. PubMed PMID: 23360888; PubMed Central PMCID: PMC3657603.

2012

Mao X, Yuan S, Fallahpour N, Ciblak A, Howard J, Padilla I, Loch-Caruso R, Alshawabkeh AN. Electrochemically induced dual reactive barriers for transformation of TCE and mixture of contaminants in groundwater. Environ Sci Technol. 2012 Nov 6;46(21):12003-11. doi: 10.1021/es301711a. Epub 2012 Oct 15. PubMed PMID: 23067023; PubMed Central PMCID: PMC3493133.

Miller MF, Chernyak SM, Domino SE, Batterman SA, Loch-Caruso R. Concentrations and speciation of polybrominated diphenyl ethers in human amniotic fluid. Sci Total Environ. 2012 Feb 15;417-418:294-8. doi: 10.1016/j.scitotenv.2011.11.088. Epub 2012 Jan 10. PubMed PMID: 22236635; PubMed Central PMCID: PMC3288287.

Mao X, Ciblak A, Baek K, Amiri M, Loch-Caruso R, Alshawabkeh AN. Optimization of electrochemical dechlorination of trichloroethylene in reducing electrolytes. Water Res. 2012 Apr 15;46(6):1847-57. doi: 10.1016/j.watres.2012.01.002. Epub 2012 Jan 8. PubMed PMID: 22264798; PubMed Central PMCID: PMC3288245.

2011

Ferguson KK, Loch-Caruso R, Meeker JD. Exploration of oxidative stress and inflammatory markers in relation to urinary phthalate metabolites: NHANES 1999-2006. Environ Sci Technol. 2012 Jan 3;46(1):477-85. doi: 10.1021/es202340b. Epub 2011 Dec 1. PubMed PMID: 22085025; PubMed Central PMCID: PMC3258337.

Ferguson KK, Loch-Caruso R, Meeker JD. Urinary phthalate metabolites in relation to biomarkers of inflammation and oxidative stress: NHANES 1999-2006. Environ Res. 2011 Jul;111(5):718-26. doi: 10.1016/j.envres.2011.02.002. Epub 2011 Feb 23. PubMed PMID: 21349512; PubMed Central PMCID: PMC3110976.

2010

Miller MF, Loch-Caruso R. Comparison of LPS-stimulated release of cytokines in punch versus transwell tissue culture systems of human gestational membranes. Reprod Biol Endocrinol. 2010 Oct 15;8:121. doi: 10.1186/1477-7827-8-121. PubMed PMID: 20950439; PubMed Central PMCID: PMC2965156.

Thiex NW, Chames MC, Loch-Caruso RK. Tissue-specific induction of COX-2 and prostaglandins in lipopolysaccharide-stimulated extraplacental human gestational membranes in a 2-chamber transwell culture system. Reprod Sci. 2010 Dec;17(12):1120-9. doi: 10.1177/1933719110378344. Epub 2010 Sep 22. PubMed PMID: 20861394; PubMed Central PMCID: PMC3096444.

2009

Thiex NW, Chames MC, Loch-Caruso RK. Tissue-specific cytokine release from human extra-placental membranes stimulated by lipopolysaccharide in a two-compartment tissue culture system. Reprod Biol Endocrinol. 2009 Oct 26;7:117. doi: 10.1186/1477-7827-7-117. PubMed PMID: 19857262; PubMed Central PMCID: PMC2774314.

Meeker JD, Hu H, Cantonwine DE, Lamadrid-Figueroa H, Calafat AM, Ettinger AS, Hernandez-Avila M, Loch-Caruso R, Téllez-Rojo MM. Urinary phthalate metabolites in relation to preterm birth in Mexico city. Environ Health Perspect. 2009 Oct;117(10):1587-92. doi: 10.1289/ehp.0800522. Epub 2009 Jun 16. PubMed PMID: 20019910; PubMed Central PMCID: PMC2790514.

Miller MF, Chernyak SM, Batterman S, Loch-Caruso R. Polybrominated diphenyl ethers in human gestational membranes from women in southeast Michigan. Environ Sci Technol. 2009 May 1;43(9):3042-6. doi: 10.1021/es8032764. PubMed PMID: 19534111; PubMed Central PMCID: PMC2700303.

2008

Tsuneta T, Loch-Caruso R, Quensen JF 3rd, Boyd SA, Hanna M, Grindatti C. Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro. Environ Res. 2008 Jun;107(2):185-93. doi: 10.1016/j.envres.2008.01.011. Epub 2008 Mar 21. PubMed PMID: 18359014; PubMed Central PMCID: PMC2699757.