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Key Personnel
Sung Kyun Park, Principal Investigator
Sioban D. Harlow, Co-Investigator
Carrie Karvonen-Gutierrez, Co-Investigator
Bhramar Mukherjee, Co-Investigator
Stuart Batterman, Co-Investigator
John F. Randolph Jr, Co-Investigator
William (Bill) H. Herman, Co-Investigator
Ellen Gold, Consultant
Mary Amburgey, Research Process Manager
Xin Wang, Research Investigator
Ning Ding, Postdoctoral Research Fellow
Seulbi Lee, Postdoctoral Research Fellow
Habyeong Kang, Postdoctoral Research Fellow
Mia Peng, PhD student
Amelia Grant-Alfieri, PhD student
Emily Zheutlin, MS student
How does exposure to multiple pollutants in real-life affect the risks of metabolic and reproductive health?
How does exposure to multiple pollutants in real-life affect the risks of metabolic and reproductive health?
The SWAN Multi-Pollutant Study (MPS) was initiated in 2016 to examine health effects of multiple environmental chemical exposures, including perfluoroalkyl and polyfluoroalkyl substances (PFAS), polychlorinated biphenyls (PCBs), organochlorine pesticides, polybrominated diphenyl ethers (PBDEs), metals, phenols, phthalates, and organophosphate pesticide among midlife women. Funded through two R01 grants by the National Institute of Environmental Health and Sciences (NIEHS), the SWAN MPS specifically investigates 1) obesity, type-2 diabetes and related metabolic endpoints (R01 ES026578); and 2) reproductive health including sex steroid hormones, age at menopause and ovarian aging (R01 ES026964).
Forever chemicals linked to hypertension in middle-aged women
Middle-aged women with higher blood concentrations of PFAS, also called “forever chemicals”, were at greater risk of developing high blood pressure, according to a new study published in Hypertension.
Study suggests expected benefit of reducing exposure to these ubiquitous chemicals might be considerable, according to a new study published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]).
Study finds PFAS exposure may cause early menopause in women
Per- and polyfluoroalkyl substance (PFAS) exposure may cause menopause to occur two years earlier in women, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
PUBLICATIONS
Wang X, Karvonen-Gutierrez CA, Gold EB, Derby C, Greendale G, Wu X, Schwartz J, Park SK. Longitudinal Associations of Air Pollution with Body Size and Composition in Midlife Women: The Study of Women’s Health Across the Nation. Diabetes Care 2022. In press. PMID:36084038.
Ding N, Karvonen-Gutierrez CA, Mukherjee B, Calafat AM, Harlow SD, Park SK. Per- and polyfluoroalkyl substances and incident hypertension in multi-racial/ethnic women: The Study of Women’s Health Across the Nation. Hypertension 2022;79(8):1876-1886. PMID: 35695012. PMCID: PMC9308661.
Park SK, Wang X, Ding N, Karvonen-Gutierrez CA, Calafat AM, Herman WH, Mukherjee B, Harlow SD. Per- and Polyfluoroalkyl Substances (PFAS) and Incident Diabetes in Midlife Women: the Study of Women’s Health Across the Nation (SWAN). Diabetologia 2022;65(7):1157-1168. PMID: 35399113. PMCID: PMC9177697.
Lee S, Karvonen-Gutierrez CA, Mukherjee B, Herman WH, Park SK. Race-specific associations of urinary phenols and parabens with adipokines in midlife women: the Study of Women’s Health Across the Nation (SWAN). Environ Pollution 2022;303:119164. PMID: 35306088.
Ding N, Harlow SD, Randolph JF, Mukherjee B, Batterman S, Gold EB, Park SK. Perfluoroalkyl Substances and Incident Natural Menopause in Midlife Women: The Mediating Role of Sex Hormones. Am J Epidemiol 2022;191(7):1212–1223. PMID: 35292812.
Wang X, Karvonen-Gutierrez CA, Herman WH, Mukherjee B, Park SK. Metals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States. Environ Res 2022; 210:112976. PMID: 35202625.
Lee S, Karvonen-Gutierrez CA, Mukherjee B, Herman WH, Harlow SD, Park SK. Urinary concentrations of phenols and parabens and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN). Environ Epidemiol 2021;5(5):e171. PMID: 34934892. PMCID: PMC8683147.
Wang X, Ding N, Harlow SD, Randolph JF, Mukherjee B, Gold EB, Park SK. Urinary metals and metal mixtures and timing of natural menopause in midlife women: the Study of Women’s Health Across the Nation. Environ Int 2021;157:106781.
Harlow SD, Hood MM, Ding N, Mukherjee B, Calafat AM, Randolph JF, Gold EB, Park SK. Per- and polyfluoroalkyl substances (PFAS) and hormone levels during the menopausal transition. J Clin Endocrinol Metabol 2021 Epub ahead of print.
Wang X, Karvonen-Gutierrez CA, Herman WH, Mukherjee B, Harlow SD, Park SK. Urinary heavy metals and longitudinal changes in blood pressure in midlife women: the Study of Women’s Health Across the Nation. Hypertension 2021;78(2):543-551.
Ding N, Karvonen-Gutierrez CA, Herman WH, Calafat AM, Mukherjee B, Park SK. Associations of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and PFAS mixtures with adipokines in midlife women. Int J Hyg Environ Health 2021;235:113777.
Ding N, Karvonen-Gutierrez CA, Herman WH, Calafat AM, Mukherjee B, Park SK. Perfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the Study of Women’s Health Across the Nation 1999-2018. Int J Obesity 2021;45(9):1937-48.
Wang X, Karvonen-Gutierrez CA, Mukherjee B, Herman WH, Park SK. Urinary metals and adipokines in midlife women: The Study of Women’s Health Across the Nation (SWAN). Environ Res 2020;110426.
Davis E, Malig B, Broadwin R, Ebisu K, Basu R, Gold EB, Qi L, Derby CA, Park SK, Wu XM. Association between coarse particulate matter and inflammatory and hemostatic markers in a cohort of midlife women. Environ Health. 2020;19(1):111.
Wang X, Karvonen-Gutierrez CA, Herman WH, Mukherjee B, Harlow SD, Park SK. Urinary metal mixtures and longitudinal changes in glucose homeostasis: The Study of Women’s Health Across the Nation (SWAN). Environ Int 2020;145:106109.
Wang X, Karvonen-Gutierrez CA, Herman WH, Mukherjee B, Harlow SD, Park SK. Urinary metals and incident diabetes in midlife women: The Study of Women’s Health Across the Nation (SWAN). BMJ Open Diabetes Res Care 2020;8(1):e001233.
Ding N, Harlow SD, Randolph JF, Calafat AM, Mukherjee B, Batterman S, Gold EB, Park SK. Associations of Perfluoroalkyl Substances with Incident Natural Menopause: the Study of Women’s Health Across the Nation. J Clin Endocrinol Metabol 2020;105(9):e3169-e3182.
Featured at Endocrine Society
Selected as an NIEHS Extramural Papers of the Month (August 2020).
Selected for the Endocrine Society Thematic Issue on Endocrine-disrupting Chemicals 2021.
Ding N, Harlow SD, Randolph Jr JF, Loch-Caruso R, Park SK. Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary. Human Reproduction Update 2020;26(5):724-752.
Ding N, Harlow SD, Batterman S, Mukherjee B, Park SK. Longitudinal trends in per- and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: the Study of Women’s Health Across the Nation. Environ Int. 2020;135:105381.
Park SK, Peng Q, Ding N, Mukherjee B, Harlow SD. Determinants of per- and polyfluoroakyl substances (PFAS) in midlife women: Evidence of racial/ethnic and geographic differences in PFAS exposure. Environ Res 2019;175:186-199.
Wang X, Mukherjee B, Batterman S, Harlow SD, Park SK. Urinary metals and metal mixtures in midlife women: The Study of Women’s Health Across the Nation (SWAN). Int J Hyg Environ Health 2019;222:778-789.
Wu X, Broadwin R, Basu R, Malig B, Ebisu K, Gold EB, Qi L, Derby C, Park SK, Green S. Associations between fine particulate matter and changes in lipids/lipoproteins among midlife women. Sci Total Environ. 2019;654:1179-1186.
Duan C. Talbott E, Brooks M, Park SK, Broadwin R, Matthews K, Barinas-Mitchell E. Five-year exposure to PM2.5 and ozone and subclinical atherosclerosis in late midlife women: the Study of Women’s Health across the Nation. Int J Hyg Environ Health 2019;222:168-176.
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