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The Team: Michael Rose, Maria Schiavone, Mark Stout, Connor Todd, Anya Wank
The Team: Michael Rose, Maria Schiavone, Mark Stout, Connor Todd, Anya Wank
Project Sponsor: Dr. Brendon Baker
Project Sponsor: Dr. Brendon Baker
The Extracellular Matrix (ECM) is a network of molecules and is composed of fibers that direct cell growth and migration. Dr. Brendon Baker has created a synthetic hydrogel with fibers to mimic this matrix to implement at sites of injury, furthering cell adhesion. Our project was to create a structure and process to magnetize and align these synthetic fibers in vitro in order to later direct cell migration in vivo.
How it Works
How it Works
Shown to the left is our CAD model of the prototype. The hydrogel containing fibers made with coated Superparamagnetic Iron Oxide Particles (SPIONs, shown below) is placed in a petri dish and secured into the device. The neodymium magnets act on the magnetic particles to align the fibers. The petri dish is removed and the fibers are microscopically analyzed.
Lab prototype to "almost finished" team prototype
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