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The Lee Lab studies how hypoxia—insufficient oxygen availability—regulates immunosuppression, tumor progression, and treatment resistance in pancreatic cancer.
Pancreatic cancer is characterized by a highly desmoplastic, hypoxic, and immunosuppressive tumor microenvironment. Our research focuses on understanding how hypoxia modulates tumor-stroma crosstalk in the pancreas, thereby developing effective anti-cancer therapies that remodel the tumor microenvironment. We employ a variety of approaches, including mouse models, 3D organoids, and single-cell RNA sequencing.
Our Goal
Our Goal
Uncover the role of hypoxia in pancreatic tumorigenesis
and identify molecular targets for therapeutic intervention.
Our Approaches
Our Approaches
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