RESEARCH

Listed below are some research studies in the past decade that involve genetic engineering in humans for their benefit

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Advances in HIV Gene Therapy Febuary 28, 2024

Rose Kitawi is a researcher and PhD student affiliated with the Kirby Institute, where she works in the Immunovirology and Pathogenesis Program. Her work focuses on advancing scientific understanding in areas such as gene therapy and virology. This study highlights ex vivo gene therapy, where scientists edit cells outside the body and ensure they're safe before reintroducing them to the patient. Using the patient's own cells prevents immune rejection, and this method has shown promise, especially in HIV research.

Bioethics Panels Open Door Slightly to Germline Gene Editing November 7, 2017

Jeff Lyon, a scientist in the field of genetics and has written multiple articles on topics related to it along with bioethics. In this article, Lyon elaborates on the use of germline cell editing through In Vitro Fertilization in women. Using data from the Oregon Health and Science University, he gives a real-life example of how diseases can be treated before a child is even born. Since he was one of the doctors on the study, he has first-hand comments on the study and efficiently explains both the study, and the ethical implications. The text explains what scientists needed to do to fix the issue and what the results were from the experiment.

LuciA-15 - a Real-World Prospective Study of PARP Inhibitors... 2023

Dr. Fernando Petracci is an oncologist of the Breast Cancer Department of the Alexander Fleming Institute and a teaching coordinator of the Institute and member of the Ethics Committee. In this article, he discusses the LuciA-15 study which evaluates the use of PARP inhibitors in treating HER2-negative metastatic breast cancer in a Latin-American population. It particularly examines patients' germline and/or somatic BRCA1/2 mutations and through genetic engineering, researchers were able to analyze tumor-specific mutations that can guide personalized therapies.

Efficient genetic engineering of human intestinal organoids using electroporation October 10, 2015

Masayuki Fujii is affiliated with the Department of Gastroenterology at Keio University School of Medicine in Tokyo, Japan, and the Department of Surgical Oncology at the University of Tokyo. His work focuses on innovative methods for studying gene function in intestinal diseases, using techniques like electroporation and CRISPR-Cas9 for precise genome editing. This study introduces a method for studying genes in human intestinal diseases using intestinal organoids—tiny, lab-grown replicas of the intestine. Instead of relying on animal models or immortalized cells, researchers can now use untransformed human colonic cells. They modify these cells by delivering genetic material through electroporation, a technique that uses electric pulses.

Physiological basis for xenotransplantation from genetically modified pigs to humans july 1, 2024

Leigh Peterson, Ph.D., is the Executive Vice President of Product Development and Xenotransplantation at United Therapeutics, a company focused on innovative medical solutions like organ manufacturing and xenotransplantation. In this article she explains the impressive progress in xenotransplantation, the process of transplanting animal organs into humans, using genetically modified pigs. These pigs have had multiple genes altered to make their organs more compatible with human bodies. The researchers managed to overcome major challenges, such as immune rejection, and successfully extended the survival of pig organs transplanted into primates.

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