Research
The Story of Endothelial Cell Chirality
Cell chirality regulates intercellular junctions and endothelial permeability
Jie Fan, Poulomi Ray, Yao Wei Lu, Gurleen Kaur, J. John Schwarz, Leo Q. Wan
Science Advances 4 (10), eaat2111, 2018
Micropatterning
We are generating micro patterned cells to study the cell-cell contact, migration and polarization which are associated with various topics of human health, including breast cancer, heart failure, neurological disorders, etc.
Immunofluorscence
We are staining various cell organelles using antibodies. The high-resolution fluorescence imaging allows us to distinguish the cell borders, axis and biases.
Programming
We are developing computational programs to track and calculate the cell morphology and handedness automatically.
Molecular assays
We are performing molecular assays to explore the signaling pathways which regulates the handedness of cells.