Research

The Story of Endothelial Cell Chirality


Cell chirality regulates intercellular junctions and endothelial permeability

Jie Fan, Poulomi Ray, Yao Wei Lu, Gurleen Kaur, J. John Schwarz, Leo Q. Wan

Science Advances 4 (10), eaat2111, 2018

Micropatterning

We are generating micro patterned cells to study the cell-cell contact, migration and polarization which are associated with various topics of human health, including breast cancer, heart failure, neurological disorders, etc.

Immunofluorscence

We are staining various cell organelles using antibodies. The high-resolution fluorescence imaging allows us to distinguish the cell borders, axis and biases.

Programming

We are developing computational programs to track and calculate the cell morphology and handedness automatically.

Molecular assays

We are performing molecular assays to explore the signaling pathways which regulates the handedness of cells.

More and more are going on now ...