Don MacCallum's Michigan Histology

A Laboratory Manual for the Novice,

as well as the more Experienced Learner of Histology

Just published, the new 2nd edition of the Don MacCallum's Michigan Histology iBook Series.

Check it out at the iBook Store.

The new 2nd edition of the Don MacCallum's Michigan Histology eBook series maintains all the excellent content of the first edition, including the high quality histological illustrations produced by Dr. MacCallum. However, many images were relabeled to make them more comprehendible. The text was carefully revised to clarify it at many points, not only to correct a number of errors, but also to add new information that is based on more recent scientific knowledge.

Book Description:

In the late 1990ies, Prof. Donald K. MacCallum put together an extremely useful hands-on histology lab manual that was based on his experience from teaching histology to many generations of University of Michigan students. Unfortunately, that original digital manual is no longer compatible with today's computer systems. The authors have updated and revised the original manual as an eBook version that allows histology learners to link the theoretical knowledge acquired in lectures and textbooks with the appearance of cells and organs as seen through a light microscope or by virtual microscopy. Starting with a chapter on staining methods and histological artifacts, the four volumes cover all basic tissues, organs and organ systems of the human body. Images of superb histological preparations produced by Prof. MacCallum are accompanied by a concise description that highlights the important aspects of each tissue's structure and correlates the appearance of these tissues at the light microscope level with their cellular organization and functions. Brief multiple choice quizzes for each chapter reinforce major learning objectives.

Don MacCallum's Michigan Histology is issued in four volumes covering all important human tissues, organs and organ systems.

The Authors:

Stephen C. Kempf is an emeritus faculty member at Auburn University in Alabama. Starting in 1985 until his recent retirement, he taught courses in histology and vertebrate development and also pursued research focused on the histological and ultrastructural aspects of Symbiodinium (zooxanthella) symbiosis and molluscan larval neurodevelopment. He may be contacted at

Michael Hortsch is a Professor in the Departments of Cell and Developmental Biology and of Learning Health Sciences at the University of Michigan Medical School in Ann Arbor, Michigan. Since 1991 he has taught medical and dental histology and in 2012 he received the University of Michigan Medical School's Kaiser Permanente Award for Excellence in Pre-clinical Teaching. His "SecondLook™ Histology" mobile review application was the winner of the 2013 University of Michigan Provost's Teaching Innovations Prize ( His research addresses how e-learning resources help or hinder students' learning success. He can be contacted at

Donald K. MacCallum retired in 2003 from the University of Michigan as a Professor in the Department of Cell and Developmental Biology. During his 34 years of tenure at the University of Michigan he was not only an extraordinary histologist and researcher, but also a dedicated teacher at both the dental and the medical school. Most of the superb histological images in these eBooks are the result of his own work, reflecting his uncompromising pursuit of excellence.


  • 26 chapters covering all basic tissues and major organs/organ systems of human histology
  • More than 1100 high quality histological images on 724 pages
  • 236 image-based multiple choice review questions
  • Volume 1: Introduction, Epithelia, Connective Tissue, Cartilage, Bone, Blood
  • Volume 2: Muscle, Nervous System, Eye, Ear, Circulatory System, Lymphatic System
  • Volume 3: Respiratory System, Integument, Oral Glands, Oral Cavity, Gastrointestinal Tract, Liver, Gall Bladder & Pancreas
  • Volume 4: Endocrine Organs, Urinary System, Male Reproductive System, Female Reproductive System, Mammary Gland

"Don MacCallum's Michigan Histology" is complemented by the Michigan Histology Virtual Slide Collections, which can be accessed for free via the Internet at

Hundreds of high quality histological images are described and explained by a concise, yet comprehensive text.


"Don MacCallum's Michigan Histology" helps the beginner, as well as the more experience student of histology, to navigate and comprehend the complexity of human tissues at the microscopic scale. It also provides an excellent review of the important aspects of histological structures.


To view this book, you must have an iPad with iBooks 2 or later and iOS 5 or later, or an iPhone with iOS 8.4 or later, or a Mac with OS X 10.9 or later.


A free sample consisting of two chapters from Vol. 1 is available at Apple's iTunes bookstore. Each complete volume of "Don MacCallum's Michigan Histology" can be downloaded for $9.99. All proceeds go to the University of Michigan and Auburn University.

For purchase, please click the following buttons.

Questions or comments:

Please contact Dr. Kempf at and/or Dr. Hortsch at

University of Michigan Medical School

© copyright 2017 Regents of the University of Michigan