Stem Cells & Regenerative Therapies
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The Stem Cells & Regenerative Therapies Working Group is focused on basic and clinically translational research efforts utilizing human bioengineered pluripotent stem cell derived cardiovascular cells, pancreatic cells and tissues. We use these bioengineered systems for in vitro research and toxicity testing and are developing approaches to deliver cells in vivo for Regenerative Therapies.
The Stem Cells & Regenerative Therapies Working Group is focused on basic and clinically translational research efforts utilizing human bioengineered pluripotent stem cell derived cardiovascular cells, pancreatic cells and tissues. We use these bioengineered systems for in vitro research and toxicity testing and are developing approaches to deliver cells in vivo for Regenerative Therapies.
Working Group Focus: Stem Cells, iPSCs, Personalized Medicine, Cardiovascular Regeneration, Pancreatic Regeneration
Weekly Working Group Meetings
Tuesday @ 11:00am
NCRC Building 26 Room 205N;(ZOOM)
**Meeting ID: 953 0726 1995 Passcode: 554756
Working Group Leader
Research Scientist, Internal Medicine and Molecular & Integrative Physiology
Director, Frankel Cardiovascular Regeneration Core Laboratory
Contact: toddherr@umich.edu
Areas of interest: Cardiac Regeneration, Pancreatic Regeneration, Personalzied Medicine, Muscle Physiology
Working Group News:
March 1, 2023: JOVE journal videographer visits CRCL to film Methods on using human induced pluripotent stem cells. https://app.jove.com/methods-collections/1598/human-vitro-assays-for-cardiac-contractility-electrophysiology Lab Alumnus Jeffery Creech returned for the filming! Thanks Jeff!
March 2, 2023: NEW EQUIPMENT installed. The CRCL is now home to a brand new Incucyte S3 Live Cell Analysis Instrument. This adds to our array of microscopes with time lapse imaging capabilities. Contact us to visualize your cells in real time!
March 3, 2023: UM Student Christian Hausner accepted to the Frankel Cardiovascular Center Summer Undergraduate Research Fellowship at the University of Michigan. Congratulations Christian!
March 19-23, 2023: Society of Toxicology (SOT) 62nd Annual Meeting and ToxExpo, Nashville TN. https://www.toxicology.org/events/am/AM2023/index.asp
June 14-17, 2023: International Society for Stem Cell Research (ISSCR) Annual Meeting 2023. Boston, MA. https://www.isscr2023.org/
Recent Publications:
Recent Publications:
Lozhkin A, Vendrov AE, Ramos-Mondragón R, Canugovi C, Stevenson MD, Herron TJ, Hummel SL, Figueroa CA, Bowles DE, Isom LL, Runge MS, Madamanchi NR.
Redox Biol. 2022 Sep 17;57:102474. doi: 10.1016/j.redox.2022.102474. Online ahead of print.
PMID: 36183542
Jimenez-Vazquez EN, Arad M, Macías Á, Vera-Pedrosa ML, Cruz FM, Gutierrez LK, Cuttita AJ, Monteiro da Rocha A, Herron TJ, Ponce-Balbuena D, Guerrero-Serna G, Binah O, Michele DE, Jalife J.
Elife. 2022 Jun 28;11:e76576. doi: 10.7554/eLife.76576.
PMID: 35762211
2022-Preventing erosion of X-chromosome inactivation in human embryonic stem cells.
Cloutier M, Kumar S, Buttigieg E, Keller L, Lee B, Williams A, Mojica-Perez S, Erliandri I, Rocha AMD, Cadigan K, Smith GD, Kalantry S.
Nat Commun. 2022 May 6;13(1):2516. doi: 10.1038/s41467-022-30259-x.
PMID: 35523820
Macías Á, Díaz-Larrosa JJ, Blanco Y, Fanjul V, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, da Rocha AM, Ponce-Balbuena D, Allan A, Filgueiras-Rama D, Jalife J, Andrés V.
Cardiovasc Res. 2022 Jan 29;118(2):503-516. doi: 10.1093/cvr/cvab055.
PMID: 33624748
*2023-JoVE64364R3 "High-throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers". Authors: Dr. Andre Monteiro da Rocha, Dr. Andrew Allan, Jeffery Creech, Dr. Travis Block and Dr. Todd J. Herron.
Read the paper here: High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers
*Part of a collection of articles recruited by the FDA/HESI in: Human In Vitro Assays for Cardiac Contractility and Electrophysiology Measurements
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