Heart Failure & Cardiomyopathy
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The Cardiomyopathy and Heart Failure Working Group is composed of investigators interested in the mechanisms of genetic and acquired heart disease. Researchers in our group are exploring the cellular dysfunction and adverse cardiac remodeling in hypertrophic and dilated cardiomyopathy, as well as acquired form of heart disease resulting from hypertension or underlying coronary heart disease, with the goal of developing effective new therapies for disease prevention. A wide variety of laboratory approaches are being used including stem cell derived human heart tissues in culture, rodent animal models, human patient tissues and clinical data, and computational modeling.
Working Group Focus: hypertrophic cardiomyopathy, dilated cardiomyopathy, heart failure, cardiac hypertrophy, cardiac injury, cardiac remodeling, fibrosis
Next Meeting: November 9th
4:00-5:00pm
Please email the working group leader if you plan to attend
Working Group Leader
Department Chair, Molecular & Integrative Physiology
John A Jacquez Collegiate Professor of Physiology
Professor, Molecular & Integrative Physiology and Internal Medicine
Contact: dmichele@umich.edu
Areas of interest: mechanisms of muscular dystrophy associated with mutations in the transmembrane dystrophin-glycoprotein complex
Professor, Internal Medicine
Contact: aalatif@med.umich.edu
Areas of interest: Interventional Cardiology, Cardiovascular Disease
Carl J. Wiggers Collegiate Professor of Cardiovascular Physiology
Professor & Associate PhD Graduate Program Chair, Molecular & Integrative Physiology
Professor, Internal Medicine
Professor, Emergency Medicine
Professor, Biomedical Engineering
Contact: beardda@med.umich.edu
Areas of interest: Cardiac energy metabolism, Oxidative metabolism and energetics in skeletal muscle, Regulation of coronary blood flow, Etiology and sequalae of hypertension
Pfizer Upjohn Early Career Research Professor of Molecular Pharmacology
Assistant Professor of Pharmacology
Assistant Professor of Internal Medicine
Contact: majbrody@med.umich.edu
Areas of interest: molecular signals that underlie cardiac disease onset and progression
J Brian Byrd MD MS
Assistant Professor of Internal Medicine
Contact: jbbyrd@med.umich.edu
https://experts.umich.edu/564-j-brian-byrd-md-ms
Areas of interest: Endocrine hypertension, aldosterone, cardiometabolic disea
Research Associate Professor, Molecular & Integrative Physiology
Contact: bcarl@med.umich.edu
Areas of interest: Blood flow regulation, Cardiovascular dynamics, Stem cell derived cardiomyocytes, Semantic-based methods of model description and sharing.
Associate Professor
Contact: lmef@med.umich.edu
Areas of interest: Interested in understanding the fundamental molecular motions and interactions that are responsible for regulating calcium transport in cardiac muscle cells, and designing effective molecular therapies to treat human diseases associated with dysregulation of calcium transport in the heart - approaching these multidisciplinary problems with a combination of multiscale computational methods and experimental techniques.
Assistant Professor, Internal Medicine
Contact: adamhelm@med.umich.edu
Areas of interest: Hypertrophic Cardiomyopathy (HCM), Familial Dilated Cardiomyopathy (DCM), Arrhythmogenic Cardiomyopathy (AC, ARVC), Inherited Arrhythmia Disorders
Research Scientist, Internal Medicine
Contact: madamanc@med.umich.edu
Areas of interest: Redox signaling, NADPH oxidases, VSMC biology, Aging, Atherosclerosis
Assistant Professor of Biomedical Engineering, College of Engineering
Contact: madukach@umich.edu
Lab Website: Maduka Lab
Areas of interest: Cardiac tissue engineering, biomaterials, immunometabolism, drug delivery for precision health
Professor, Molecular & Integrative Physiology
Professor, Internal Medicine
Professor, Pharmacology
Contact: rmort@umich.edu
Areas of interest: understand basic mechanisms in the consequences and treatment of obesity, diabetes and related cardiovascular disease. Major focus has been on the role of PPAR (peroxisome proliferators-activate receptor) and mineralocorticoid (MR) transcription factors in inflammation, cell growth and cardiovascular disease (vascular and cardiac dysfunction in diabetes)
Professor of Internal Medicine
Director of Institute for Heart and Brain Health (IHBH)
Contact: anthros@med.umich.edu
Areas of interest: Expertise:Research interests have focused on identifying new mechanisms and targets in heart failure, with a particular interest in noncoding RNA pathways. In this context, the laboratory has identified novel pathways that are functionally important in the heart’s response to both pathological and physiological stimuli. The lab has had a longstanding interest in understanding how exercise protects against cardiovascular disease and how this interacts with aging.
Horace W. Davenport Collegiate Professor of Physiology
Professor, Molecular & Integrative Physiology
Professor, Internal Medicine
Contact: shahy@umich.edu
Areas of interest:The major goal of our research program is to determine the molecular mechanisms by which oxygen sensing transcription factors regulate gastrointestinal homeostasis, inflammation and cancer.
Associate Chair, DEI
Professor of Pharmacology, Medical School
Professor of Biophysics, College of Literature, Science, and the Arts
Benedict R Lucchesi Collegiate Professor of Cardiovascular Pharmacology
Contact: avsmrcka@med.umich.edu
Areas of interest: Our laboratory focuses on analysis of the interactions between the G proteins and their protein targets at a molecular and structural level with the goal of understanding how these interactions lead to alterations in protein and cellular activities.Another goal is to connect the biochemical information about protein interaction interfaces to specific cellular physiologies. To this end we are developing antagonists of specific G protein interactions and using these tools to probe the functions of those interactions in living cells. This approach will help to define the roles of specific G protein interactions in physiological processes and as potential targets for therapeutic intervention in cardiovascular disease or cancer.
Assistant Professor, Environmental Health Science
Contact: lmyrant@med.umich.edu
Areas of interest: understanding the sex-specific effects of developmental chemical exposures on cardiac differentiation and cardiovascular health across the life course
Assistant Professor, Internal medicine
Contact: adooley@med.umich.edu
Areas of interest: Dr. Thompson’s research interests include basic and translational research focused on cardiomyopathies. This includes;
1. Identifying modifiers of disease onset and progression in cardiomyopathies.
2. Uncovering novel disease modifying targets and developing small molecules to treat cardiomyopathies.
3. Defining the molecular mechanisms by which MYBPC3 missense variants lead to hypertrophic cardiomyopathy.
4. Developing strategies to better understand and characterize variants of uncertain significance. 5. Understanding biological pathways which drive recovery after cardiogenic shock
Assistant Professor, Molecular & Integrative Physiology
Research Assistant Professor, Institute of Gerontology
Contact: mtruttma@med.umich.edu
Areas of interest: Aggregation-associated, neurodegenerative diseases (NDs) pose a major societal and economic burden that drastically affects the lives of both patients and family caretakers. We are particularly interested in a novel PTM, termed AMPylation, that regulates the activity of heat shock protein 70 (Hsp70) family proteins.
Assistant Professor, Biomedical Engineering
Contact: alisonvr@umich.edu
Vander Roest Cardiac Mechanobiology Lab
Areas of interest: focus on understanding the molecular basis of cardiac contraction and the cellular responses that affect changes in the heart during disease. We use a combination of in vitro cell systems (primarily human iPSC-derived heart cells) as well as computational models to understand the mechanisms of force generation, propagation and remodeling in the heart.
Associate Professor, Internal Medicine
Contact: zhongw@med.umich.edu
Areas of interest: pigenetic mechanisms of cardiac cell metabolism, cardiac progenitor differentiation and reprogramming, and development of novel strategies for heart repair and regeneration
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