Aortic Disease, Structural Heart & Hypertension
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The goal of the Aortic Disease, Structural Heart and Hypertension working group is to bring together a group of scientists with an interest in diseases of the aortic and heart to help facilitate collaborations and help connect laboratories interested in aortic and heart disease research. This working group has formal meetings in the form of monthly “Research in Progress” seminars where students and faculty present their current research for group discussion and potential collaboration opportunities. Informal meetings of the group through social occasions and happy hours will also bring researchers together to interact and relax once a quarter. A goal of these meetings is to help foster the development of formal collaborations through federal R01 grants and program project grants as well as to develop networking and academic support amongst colleagues.
Working Group Focus: Genetics and Epigenetics, Cardiovascular Development, Cardiac Biology and Regulation, Prevention, Management, and Intervention, Data Science, Genomics and Translational Biology, Surgery and Anesthesia, Non-Atherosclerotic Disease, Vascular Biology and Blood Pressure Regulation, Aging, Cardiovascular Drug Development
Trainee Opportunities
Trainee Opportunities
The F-CVC SURF Program is one of many opportunities available to trainees interested in Vascular Biology Research
Protocol Library
Protocol Library
Lineage tracing of mouse abdominal aortic aneurysm smooth muscle cells
Working group leader, Dr. Morgan Salmon, presented at the 4th Annual M-BoCA symposium.
Events
Dr. Gib Upchurch, Chair of Surgery at the University of Florida, is presenting in person at Mi-Aorta Meeting on November 3, 2023.
He has been investigating mechanisms of abdominal aortic aneurysms for over 20 years!
Working Group Leader
Contact: msalmon@med.umich.edu
Areas of Interest: Epigenetics, Smooth Muscle Cell Biology, Krüppel-like Factor Biology, Translational Medicine
Contact: ailawadi@med.umich.edu
Areas of interest: Minimally invasive valve surgery, minimally invasive mitral surgery, percutaneous therapies, aortic aneurysm surgery, aortic root/David procedure and Hypertrophic obstructive cardiomyopathy (HOCM)
Contact: davisfr@med.umich.edu
Areas of interest: Vascular Surgery, Surgical and Endovascular Management of Aortic Aneurysm, Aorto-Iliac Occlusive Disease, Cerebral Vascular Disease, and Peripheral Arterial Disease
Contact: robertbh@med.umich.edu
Areas of interest: CABG, Coronary Artery Bypass Grafting, TAVR, Transcatheter Aortic Valve Replacement, Surgical Aortic Valve Replacement, MVR, Mitral Valve Repair, Aortic Aneurysm Repair, LVAD, Ventricular Assist Device Placement, Heart Transplantation
Contact: dmizrak@med.umich.edu
Areas of interest: characterizing novel mutations contributing to aortopathy in aortic aneurysm and dissection patients, and developing novel pharmacological strategies to prevent disease progression
Contact: jifengz@med.umich.edu
Areas of interest: Smooth Muscle cells, PPARs, Vascular Biology, Endothelial Function, Vascular Physiology, Cardiovascular Biology, Cell Culture, Atherosclerosis, epigenetics
Contact: wfall@med.umich.edu
Areas of interest: understanding the contribution of the sarcomere to cardiac dysfunction and heart failure
Contact: zhongw@med.umich.edu
Areas of interest: epigenetic mechanisms of cardiac cell metabolism, cardiac progenitor differentiation and reprogramming, and development of novel strategies for heart repair and regeneration
a. Daniel J. Tyrrell, Judy Chen, Benjamin Y. Li, Sherri C. Wood, Wendy Rosebury-Smith, Henriette A. Remmer, Longtan Jiang, Min Zhang, Morgan Salmon, Gorav Ailawadi, Bo Yang and Daniel R. Goldstein. Aging Alters the Aortic Proteome in Health and Thoracic Aortic Aneurysm. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022;42:1060–1076.
b. Dong Zhou, Hao Feng, Ying Yang, Tingting Huang, Ping Qiu, Chengxin Zhang, Timothy R. Olsen, Jifeng Zhang, Y. Eugene Chen, Dogukan Mizrak and Bo Yang. hiPSC Modeling of Lineage-Specific Smooth Muscle Cell Defects Caused by TGFBR1A230T Variant, and Its Therapeutic Implications for Loeys-Dietz Syndrome Circulation. 2021;144:1145–1159.
c. Tingting Huang, Jiaxi Cheng, Hao Feng, Wei Zhou, Ping Qiu, Dong Zhou, Dongshan Yang, Jifeng Zhang, Cristen Willer, Y Eugene Chen, Dogukan Mizrak, Bo Yang. Bicuspid Aortic Valve-Associated Regulatory Regions Reveal GATA4 Regulation and Function During Human-Induced Pluripotent Stem Cell-Based Endothelial-Mesenchymal Transition. Arterioscler Thromb Vasc Biol. 2022 Dec 15. doi: 10.1161/ATVBAHA.122.318566.
d. Davis FM, Tsoi LC, Ma F, Wasikowski R, Moore BB, Kunkel SL, Gudjonsson JE, Gallagher KA. Single-cell Transcriptomics Reveals Dynamic Role of Smooth Muscle Cells and Enrichment of Immune Cell Subsets in Human Abdominal Aortic Aneurysms. Ann Surg. 2022 Sep 1;276(3):511-521. doi: 10.1097/SLA.0000000000005551. Epub 2022 Jun 28.
e. Davis FM, Tsoi LC, Melvin WJ, denDekker A, Wasikowski R, Joshi AD, Wolf S, Obi AT, Billi AC, Xing X, Audu C, Moore BB, Kunkel SL, Daugherty A, Lu HS, Gudjonsson JE, Gallagher KA. Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms. J Exp Med. 2021 Jun 7;218(6). doi: 10.1084/jem.20201839.
f. Narahari AK, Mehaffey JH, Chandrabhatla AS, Hawkins RB, Charles EJ, Roeser ME, Lau C, Ailawadi G. Longitudinal analysis of National Institutes of Health funding for academic thoracic surgeons. J Thorac Cardiovasc Surg. 2022 Mar;163(3):872-879.e2. doi: 10.1016/j.jtcvs.2021.01.088. Epub 2021 Feb 3.
g. Mehaffey JH, Hawkins RB. Aortic Root Enlargement-Defining Risk and Reward. Ann Thorac Surg. 2022 Feb;113(2):700-701. doi: 10.1016/j.athoracsur.2021.03.005.
h. Hawkins RB, Salmon M, Su G, Lu G, Leroy V, Bontha SV, Mas VR, Jr GRU, Ailawadi G, Sharma AK. Mesenchymal Stem Cells Alter MicroRNA Expression and Attenuate Thoracic Aortic Aneurysm Formation. J Surg Res. 2021 Dec; 268:221-231. doi: 10.1016/j.jss.2021.06.057. Epub 2021 Aug 7.
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