SEssion 4: Molecular mechanisms of disease, cancer biology, genetics of disease, non-human models of disease
Friday, May 20th, 1:00 PM - 4:00 PM
Questions? Email cmbgrad@umich.edu.
Odd numbered posters presenting from 1:30 PM — 2:45 PM
Even numbered posters presenting from 2:45 PM — 4:00 PM
Poster Number, Abstract Title & Authors
37 — Gene silencing in SCA3 disease mice rescues spatiotemporal oligodendrocyte impairments
Kristen H Schuster, Annie J Zalon, Danielle DiFranco, Alexa Putka, Sabrina Jarrah, Nicolas
Stec, Arsal Naeem, Zaid Haque, Hongjiu Zhang, Yuanfang Guan, Hayley S. McLoughlin
38 — Multiomics analysis to uncover the mechanism of radiosensitization of androgen receptor-positive triple negative breast cancers with AR inhibition
Anna R. Michmerhuizen*, Andrea M. Pesch, Benjamin C. Chandler, Lynn M. Lerner
Connor Ward, Leah Moubadder, Stephanie The, Breanna McBean, Caleb Cheng, Lori J.Pierce,
Corey W. Speers
39— Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation
Lenglam Lei, Shuo Tian, Wenbin Gao, Liu Liu, Yijing Guo, Paul C Tang, Y. Eugene Chen, Zhong Wang
40 — Leveraging Proteostasis for Niemann-Pick C Gene Therapy
Ruth Azaria*, Mark Schultz, Andrew Lieberman
41 — INCB090244 is a selective and orally bioavailable small molecule that potently inhibits PD-L1 and induces antitumor immunity
**Jonathan Rios-Doria, Alla Volgina, Prafulla C. Gokhale, Hao Liu, Christina Stevens, Nina Zolotarjova, Darlise DiMatteo, Kanishk Kapilashrami, Elham Behshad, Pramod Thekkat, Gengjie Yang, Leslie Hall, Chrysi Kanellopoulou, Mark Rupar, Christopher Maddage, April Horsey, Krista Burke, Yan-ou Yang, Maryanne Covington, Steve Wang, Phillip Liu, Richard Wynn, David A. Reardon, Holly Koblish
**CMB Alum
42 — Overcoming Adaptive Resistance to MEK inhibition by activation of Protein Phosphatase 2A (PP2A) in KRAS-mutant cancers
Brynne Raines*, Goutham Narla
43 — Reactivation of Gamma Globin Expression in β-Hemoglobinopathies
Ginette Balbin-Cuesta*, Rami Khoriaty
44 — Deep Mutagenesis Scan of SERPINC1 to inform variants affecting thrombosis risk
Christopher Bidlack*, Krista Golden, Mary Underwood, and Karl Desch
45— Ankyrin-G in Developmental and Epileptic Encephalopathy
Carina Elvira*, Paul Jenkins
46 — Combatting Cholesterol Accumulation in Niemann-Pick Type C Disease
Adele Correia*, Andrew Lieberman
47 — Targeting DNA Double Strand Break Repair in Homologous Recombination Proficient High Grade Serous Ovarian Cancers
***Erika Nakatsuka, MD, PhD, Lijun Tan, Caroline Foster, **Karen McLean, MD, PhD
*** Postdoctoral Fellow **CMB Alum
48 — CRTC1-MAML2 fusion translocation and transcription regulation in mucoepidermoid carcinoma
Gensterblum-Miller E*, Heft Neal M.E., Bhangale A.D., Brenner J.C.
49 — Ribosomal quality control in repeat-associated non-AUG translation of GC rich repeats
Yi-Ju Tseng*, Peter K. Todd
50— MDM2 inhibition as a non-hormone dependent radiosensitizing strategy in p53 wild-type breast cancer models
Charles A. Nino*, Cassandra Lynne Ritter, Andrea M. Pesch, Anna R. Michmerhuizen*,
Benjamin C. Chandler, Nicole Hirsch, Tanner Ward, Yashmeet Kaur, Maria Fields, Lori J.Pierce,
Corey W. Speers
51 — Microbiota metabolic exchange is critical for colorectal cancer redox homeostasis and growth
Hannah Bell*, Joshua Goyert, Yatrik Shah
52— FIC-1/FICD-mediated AMPylation of HSP70 family chaperones modulates polyglutamine toxicity
Kate M. Van Pelt* , Matthias C. Truttmann
53 — Evaluating shared molecular features and potential vulnerabilities of low-H3K27me3 pediatric brain tumors
Matthew Pun*, Sriram Venneti MD, PhD
54 — RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia McMillan M*, Gomez N*, Bekier M, Li X, Miguez R, Tank EM, Barmada SJ
55 — Exogenous UPF1 corrects TDP-43-directed NMD-sensitization of the transcriptome in neuronal models of ALS
Nicolas Gomez*, Elizabeth Tank PhD, Sami Barmada MD PhD
56 — Investigating the Mechanism of Estrogen Induced Thrombosis
Sylvia Emly*, Jordan Shavit
57 — The role of PTEN in epigenetic and metabolic regulation of IDH-mutant gliomas
James Haggerty-Skeans*, Siva Kumar Natarajan,Drew Pratt, Sriram Venneti
Presenting author, *CMB Student, CMB faculty presenter