Beard Lab

Myocardial metabolism and mechanics in cardiovascular physiology

Our laboratory uses a combination of experimental and systems modeling approaches to understanding the operation of physiological systems in health and disease. Current projects use multi-scale models to simulate the integrated operation of metabolic pathways (e.g., oxidative ATP synthesis in the heart), cellular functions (e.g., cellular calcium handling and actin/myosin cross-bridge dynamics), whole-organ function (e.g., mechanics of cardiac pumping), and whole-body body cardiopulmonary function. Dr. Beard currently supervises trainees from several different degree-granting programs in the university, and organizes and teaches in courses in physiology, bioinformatics, and computational biology.

Myocardial coupling of metabolic energy supply and mechanical power generation

In this project we are probing the molecular and cellular coupling of energy metabolism and cardiomyocyte mechanics.

Myocardial energy metabolism in vitro and in vivo

The goal of this project is to gain a quantitative predictive understanding of muscle metabolism under a range of dynamic conditions. 


Multiscale multiphysics model of cardiovascular funtion to guide diagnostics, prognostics, and therapeutics

Under this project we are constructing digital twins from patient record data and combining machine learning and precision phenotyping to guide diagnosis, prognosis, and treatment in heart failure



Metabolic and mechanical determinants of reserve cardiac power output in heart failure

In this project we are investigating how the biochemical/metabolic state of the heart in heart failure limits reserve cardiac power capacity.