Professor Brad Zebrack has been awarded a 5-year R01 from the National Cancer Institute for the project "Social genomic mechanisms of health disparities among adolescent and young adult (AYA) cancer survivors." The grant will allow study of molecular pathways that represent potential targets for interventions to protect AYA survivors against the adverse biological effects of social isolation, socioeconomic disadvantage, and other psychological and social determinants of health in the highly stressful context of cancer. The study’s intent is to identify functional genomic pathways through which social and psychological factors influence gene regulation and alter health outcomes in AYAs, and to define the role of such effects in structuring health disparities in post-treatment survivorship.