Research

Our team has been working to understand the health impacts of dietary flavonoids for decades. Here you'll find some of our prior published work:

1: Hughes RL, Frankenfeld CL, Gohl DM, Huttenhower C, Jackson SA, Vandeputte D, Vogtmann E, Comstock SS, Kable ME. Methods in Nutrition & Gut Microbiome Research: An American Society for Nutrition Satellite Session [13 October 2022]. Nutrients. 2023 May 24;15(11):2451. doi: 10.3390/nu15112451. PMID: 37299414; PMCID: PMC10255073.

2: Frankenfeld CL, Hullar MAJ, Maskarinec G, Monroe KR, Shepherd JA, Franke AA, Randolph TW, Wilkens LR, Boushey CJ, Le Marchand L, Lim U, Lampe JW. The Gut Microbiome Is Associated with Circulating Dietary Biomarkers of Fruit and Vegetable Intake in a Multiethnic Cohort. J Acad Nutr Diet. 2022 Jan;122(1):78-98. doi: 10.1016/j.jand.2021.05.023. Epub 2021 Jul 3. PMID: 34226163; PMCID: PMC9019929.

3: Miller LM, Lampe JW, Newton KM, Gundersen G, Fuller S, Reed SD, Frankenfeld CL. Being overweight or obese is associated with harboring a gut microbial community not capable of metabolizing the soy isoflavone daidzein to O-desmethylangolensin in peri- and post-menopausal women. Maturitas. 2017 May;99:37-42. doi: 10.1016/j.maturitas.2017.02.006. Epub 2017 Feb 16. PMID: 28364866.

4: Frankenfeld CL. Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes. Mol Nutr Food Res. 2017 Jan;61(1). doi: 10.1002/mnfr.201500900. Epub 2016 Aug 30. PMID: 27470596.

5: Atkinson C, Ray RM, Li W, Lin MG, Gao DL, Shannon J, Stalsberg H, Porter PL, Frankenfeld CL, Wähälä K, Thomas DB, Lampe JW. Plasma equol concentration is not associated with breast cancer and fibrocystic breast conditions among women in Shanghai, China. Nutr Res. 2016 Aug;36(8):863-71. doi: 10.1016/j.nutres.2016.03.008. Epub 2016 Mar 30. PMID: 27440541; PMCID: PMC4987235.

6: Frankenfeld CL, Sikaroodi M, Lamb E, Shoemaker S, Gillevet PM. High-intensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States. Ann Epidemiol. 2015 Oct;25(10):736-42.e4. doi: 10.1016/j.annepidem.2015.06.083. Epub 2015 Jul 17. PMID: 26272781.

7: Frankenfeld CL. Cardiometabolic risk factors are associated with high urinary enterolactone concentration, independent of urinary enterodiol concentration and dietary fiber intake in adults. J Nutr. 2014 Sep;144(9):1445-53. doi: 10.3945/jn.114.190512. Epub 2014 Jun 25. PMID: 24966407.

8: Frankenfeld CL, Atkinson C, Wähälä K, Lampe JW. Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein. Eur J Clin Nutr. 2014 Apr;68(4):526-30. doi: 10.1038/ejcn.2014.23. Epub 2014 Feb 26. PMID: 24569543; PMCID: PMC4189015.

9: Frankenfeld CL. Relationship of obesity and high urinary enterolignan concentrations in 6806 children and adults: analysis of National Health and Nutrition Examination Survey data. Eur J Clin Nutr. 2013 Aug;67(8):887-9. doi: 10.1038/ejcn.2013.107. Epub 2013 Jun 12. PMID: 23756386.

10: Frankenfeld CL. O-desmethylangolensin: the importance of equol's lesser known cousin to human health. Adv Nutr. 2011 Jul;2(4):317-24. doi: 10.3945/an.111.000539. Epub 2011 Jun 28. PMID: 22332073; PMCID: PMC3125681.

11: Frankenfeld CL. Dairy consumption is a significant correlate of urinary equol concentration in a representative sample of US adults. Am J Clin Nutr. 2011 May;93(5):1109-16. doi: 10.3945/ajcn.111.011825. Epub 2011 Mar 9. PMID: 21389178.

12: Lampe JW, Nishino Y, Ray RM, Wu C, Li W, Lin MG, Gao DL, Hu Y, Shannon J, Stalsberg H, Porter PL, Frankenfeld CL, Wähälä K, Thomas DB. Plasma isoflavones and fibrocystic breast conditions and breast cancer among women in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2579-86. doi: 10.1158/1055-9965.EPI-07-0368. PMID: 18086761.

13: Song KB, Atkinson C, Frankenfeld CL, Jokela T, Wähälä K, Thomas WK, Lampe JW. Prevalence of daidzein-metabolizing phenotypes differs between Caucasian and Korean American women and girls. J Nutr. 2006 May;136(5):1347-51. doi: 10.1093/jn/136.5.1347. PMID: 16614428.

14: Frankenfeld CL, Atkinson C, Thomas WK, Gonzalez A, Jokela T, Wähälä K, Schwartz SM, Li SS, Lampe JW. High concordance of daidzein-metabolizing phenotypes in individuals measured 1 to 3 years apart. Br J Nutr. 2005 Dec;94(6):873-6. doi: 10.1079/bjn20051565. PMID: 16351761.

15: Frankenfeld CL, McTiernan A, Thomas WK, LaCroix K, McVarish L, Holt VL, Schwartz SM, Lampe JW. Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes. Maturitas. 2006 Feb 20;53(3):315-24. doi: 10.1016/j.maturitas.2005.05.016. Epub 2005 Jul 12. PMID: 16019168.

16: Atkinson C, Frankenfeld CL, Lampe JW. Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health. Exp Biol Med (Maywood). 2005 Mar;230(3):155-70. doi: 10.1177/153537020523000302. PMID: 15734719.

17: Frankenfeld CL, Atkinson C, Thomas WK, Goode EL, Gonzalez A, Jokela T, Wähälä K, Schwartz SM, Li SS, Lampe JW. Familial correlations, segregation analysis, and nongenetic correlates of soy isoflavone-metabolizing phenotypes. Exp Biol Med (Maywood). 2004 Oct;229(9):902-13. doi: 10.1177/153537020422900906. Erratum in: Exp Biol Med (Maywood). 2004 Dec;229(11):1206. PMID: 15388885.

18: Frankenfeld CL, McTiernan A, Aiello EJ, Thomas WK, LaCroix K, Schramm J, Schwartz SM, Holt VL, Lampe JW. Mammographic density in relation to daidzein-metabolizing phenotypes in overweight, postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1156-62. PMID: 15247126.

19: Frankenfeld CL, McTiernan A, Tworoger SS, Atkinson C, Thomas WK, Stanczyk FZ, Marcovina SM, Weigle DS, Weiss NS, Holt VL, Schwartz SM, Lampe JW. Serum steroid hormones, sex hormone-binding globulin concentrations, and urinary hydroxylated estrogen metabolites in post-menopausal women in relation to daidzein-metabolizing phenotypes. J Steroid Biochem Mol Biol. 2004 Apr;88(4-5):399-408. doi: 10.1016/j.jsbmb.2004.01.006. PMID: 15145450.

20: North American Menopause Society. The role of soy isoflavones in menopausal health: report of The North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010). Menopause. 2011 Jul;18(7):732-53. doi: 10.1097/gme.0b013e31821fc8e0. PMID: 21685820.

21: Frankenfeld CL, Maskarinec G, Franke AA. Metabolomics profiles of premenopausal women are different based on <i>O</i>-desmethylangolensin metabotype. Br J Nutr. 2022 Oct 28;128(8):1490-1498. doi: 10.1017/S0007114521004463. Epub 2021 Nov 12. PMID: 34763731; PMCID: PMC9095764.