Ease-of-use, which in particular includes sample-to-answer operation, is the key to moving diagnostics away from the central lab. Our group invents new approaches to eliminate precise operational steps from sample preparation and assay operation in order to make diagnostics easier to use. We are currently applying our assay automation strategies, such as thermally responsive alkane partitions (TRAPs), to the detection of viruses in blood samples.
Funding: NIAID (R01AI176197), Maryland Device Development Fund
Peer-reviewed publications:
Miso Na, David J. Boegner, Micaela L. Everitt, and Ian M. White, Thermally Responsive Alkane Partitions and a Magnetofluidic Assay for Point-of-Sample Detection of Viruses in Wastewater, Biosensors, 15, 276, 2025. DOI:10.3390/bios15050276.
David J. Boegner, John R. Rzasa, Evan H. Benke, and Ian M. White, Saliva-STAT: Sample-to-answer saliva test for COVID-19, Sensors and Actuators B: Chemical, 136510, 2024. DOI:10.1016/j.snb.2024.136510.
David J. Boegner, Miso Na, Anthony D. Harris, Robert H. Christenson, Colleen M. Damcott, Brent King, LaToya Stubbs, Peter Rock, and Ian M. White, Sample-to-answer detection of SARS-CoV-2 viremia using thermally responsive alkane partitions, Analytical Chemistry, 96, 12049–12056, 2024. DOI:10.1021/acs.analchem.4c02105.
Micaela L. Everitt, David J. Boegner, and Ian M. White, Sample-to-Answer Immuno-Magnetic Assay Using Thermally Responsive Alkane Partitions, Biosensors, 12, 1030, 2022. DOI:10.3390/bios12111030.
David J. Boegner, Micaela L. Everitt, and Ian M. White, Thermally Responsive Alkane Partitions for Assay Automation, ACS Applied Materials and Interfaces, 14, 8865–8875, 2022. DOI:10.1021/acsami.2c00493.
John P. Goertz and Ian M. White, Phase-change partitions for thermal automation of multi-step reactions, Analytical Chemistry, 90, 3708–3713, 2018. DOI:10.1021/acs.analchem.7b05400.