A. Peer-Review Publications
Salt-inducible kinases regulate androgen synthesis in theca cells by enhancing CREB signaling Miriam Rodriguez Esquivel a, Emily Hayes a, Oliwia Lakomy a, Mariam Hassan a, Marc Foretz b, Carlos Stocco. Molecular and Cellular Endocrinology 577 (2023) 112030
Insulin-like Growth Factor 1 Enhances Follicle-Stimulating Hormone-Induced Phosphorylation of GATA4 in Rat Granulosa Cells. (2022) Convissar C, Bennett-Toomey J, and Stocco C Molecular and Cellular Endocrinology 559 (2023) 111807
Mechanism of Negative Modulation of FSH Signaling by Salt-Inducible Kinases in Rat Granulosa Cells. (2022) Armouti M, Rodriguez Esquivel M, and Stocco C Frontiers in Endocrinology - Reproduction Front. Endocrinol. 13:1026358. doi: 10.3389/fendo.2022.1026358.
Oocyte-secreted factors strongly stimulate sFRP4 expression in human cumulus cells. (2021) Esfandyari S, Winston NJ, Fierro MA, Scoccia H, and Stocco C Mol Hum Reprod. 29: 27-26.
Salt Inducible Kinases Are Critical Determinants of Female Fertility. (2020) Armouti M, Winston N, Hatano O, Hobeika E, Hirshfeld-Cytron J, Liebermann J, Takemori H, Stocco C Endocrinology 161: 1–13.
Regulation of Insulin-Like Growth Factor 2 by Oocyte-Secreted Factors in Primary Human Granulosa Cells. (2020) Hobeika E, Armouti M, Fierro MA, Winston NJ, Zamah MA, Scoccia B, Stocco C Journal of Clinical Endocrinology and Metabolism 105:327-335. A draft of this manuscript was sent to the Chicago Gynecological Society and won 1st Prize in the category of Fellow Paper Award.
Oocyte-Secreted Factors Synergize With FSH to Promote Aromatase Expression in Primary Human Cumulus Cells. (2019) Hobeika E, Armouti M, Kala H, Fierro MA, Winston NJ, Scoccia B, Zamah AM, Stocco C. Journal of Clinical Endocrinology and Metabolism 104:1667-1676.
Sp1 regulates steroidogenic genes and LHCGR expression in primary human luteinized granulosa cells. (2019) Convissar S, Winston NJ, Fierro MA, Scoccia H, Zamah AM, Stocco C. J Steroid Biochem Mol Biol. 90:183-192.
Regulation of AMH by GDF9 plus BMP15 in human primary cumulus cells. (2017) Convissar S, Armouti M, Fierro MA, Winston NJ, Scoccia H, Zamah A, and Stocco C. Reproduction 154:745-753. * Editor Choice on the December 2017 Issue of Reproduction.
Baumgarten, SC, Armouti M, Ko C, and Stocco C. (2017) - Conditional Deletion of Insulin Growth Factor Receptor 1 in Granulosa Cells Causes Infertility. Endocrinology 158: 2309–2318. This manuscript was highlighted on the website of the journal. A commentary about this publication was written to emphasize the novelty and significance of these findings (see “Female Fertility: It takes two to tango” (Endocrinology 158:2074-2076).
Stocco C, Baumgarten SC, Armouti M, Fierro MA, Winston N, Scoccia B, and Zamah, AM (2017). Genome-wide interactions between follicle-stimulating hormone and insulin-like growth factors in the regulation of human granulosa cell differentiation. Human Reproduction. 32:905-914.
Convissar SM, Bennett J, Baumgarten SC, Lydon JP, DeMayo FJ, Stocco C (2015) GATA4 and GATA6 Knockdown During Luteinization Inhibits Progesterone Production and Gonadotropin Responsiveness in the Corpus Luteum of Female Mice. Biol Reprod. 93:133-139.
Baumgarten SC, Convissar SM, Zamah MA, Fierro MA, Winston NJ, Scoccia B, and Stocco C (2015) FSH Regulates IGF2 Expression in Human Granulosa Cells in an AKT-dependent Manner. Journal of Clinical Endocrinology and Metabolism. 100:1046–1055.
Baumgarten SC, Convissar SM, Fierro MA, Winston MJ, Scoccia B, and Stocco C (2014) IGF1R signaling is necessary for FSH-induced activation of AKT and differentiation of human cumulus granulosa cells. Journal of Clinical Endocrinology and Metabolism. 99:2995-3004.
Bennett J, Baumgarten SC, Stocco C. (2013) GATA4 and GATA6 Silencing in Ovarian Granulosa Cells Affects Levels of mRNAs Involved in Steroidogenesis, Extracellular Structure Organization, IGF-I Activity, and Apoptosis. Endocrinology. 154:4845-58
Wu Y-G, Baumgarten SC, Zhou P, and Stocco C. (2013) Testosterone-Dependent Interaction between Androgen Receptor and Aryl Hydrocarbon Receptor Induces Liver Receptor Homolog 1 Expression in Rat Granulosa Cells. Molecular and Cellular Biology 15: 2817-28.
Zhou P, Baumgarten SC, Wu YG, Bennett J, Winston N, Hirshfeld J, and Stocco C (2013). IGF1 signaling mediates FSH stimulation of AKT and subsequent expression of steroidogenic and differentiation genes in granulosa cells. Mol. Endocrinol. 27: 511–523. PMCID:PMC3589673.
Lockwood CJ, Kayisli UA, Stocco C, Murk W, Vatandaslar E, Buchwalder LF, and Schatz F. (2012) Abruption-induced preterm delivery is associated with thrombin-mediated functional progesterone withdrawal in decidual cells. Am J Pathol. 181:2138-48.
Bennett J, Wu YG, Gossen J, Zhou P, and Stocco C (2012) Loss of GATA-6 and GATA-4 in Granulosa Cells Blocks Folliculogenesis, Ovulation, and Follicle Stimulating Hormone Receptor Expression Leading to Female Infertility. Endocrinology 153:2474-85.6.
Stocco C (2012) Tissue physiology and pathology of aromatase. Steroids 77:27-35.
Wu Y-G, Bennett J, Talla D, and Stocco C (2011) Testosterone, not 5α-Dihydrotestosterone Stimulates LRH-1 Leading to FSH-independent Expression of Cyp19 and P450scc in Granulosa Cells. Mol Endocrinol 25:656-68.
Lockwood CJ, Stocco C, Murk K, Kayisli UA, Funai EF, & Schatz F (2010) Human labor is associated with reduced decidual cell expression of progesterone, but not glucocorticoid, receptors. J Clin Endocrinol Metab 95:2271-5.
Devi S, Shehu A, Halperin J, Stocco C, Le J, Seibold A, & Gibori G (2009) Prolactin Signaling through the Short Isoform of the Mouse Receptor Regulates DNA Binding of Specific Transcription Factors, Often with Opposite Effects in Different Reproductive Tissues. Reproductive Biology and Endocrinology 24:7:87.
Devi YS, Shehu A, Stocco C, Halperin J, Le J, Seibold AM, Lahav M, Binart N, Gibori G (2009) Regulation of transcription factors and repression of Sp1 by prolactin signaling through the short isoform of its cognate receptor. Endocrinology 150:3327-3335.
Stocco C (2008) Aromatase Expression in the Ovary: Hormonal and Molecular Regulation. Steroids 73:473–487.
Halperin J, Devi S, Elizur S, Stocco C, Shehu A, Rebourcet D, Unterman T, Leslie N, Le J, Binart N and Gibori G (2008) Prolactin Signaling Through the Short Form of Its Receptor Represses FOXO3 and its Target Gene Galt Causing a Severe Ovarian Defect. Mol Endocrinol 22:513-522.
Stocco C, Kwintkiewicz J, Cai Z (2007) Identification of regulatory elements in the Cyp19 proximal promoter in rat luteal cells. Journal of Molecular Endocrinology 39:211-221.
Kwintkiewicz J, Cai Z & Stocco C. (2007) Follicle Stimulating Hormone-Induced Activation of Gata4 Contributes in the Upregulation of Cyp19 Expression in Rat Granulosa Cells. Mol Endocrinol. 21:933-947.
Stocco C, Telleria C & Gibori G (2007) The Molecular Control of Corpus Luteum Formation, Function and Regression. Endocrine Review 28:117-149.
Krikun G, Fchatz F, Salafia C, Huang S-T, Stocco C & Lockwood C (2007) Thrombin Activation of Endometrial Endothelial Cells. A Possible Role in Intrauterine Growth Restriction. Thrombosis and Haemostasis 97:245-253.
Cai Z, Kwintkiewicz J, Young ME, & Stocco C (2007) Prostaglandin E2 Increases cyp19 Expression in Rat Granulosa Cells: Implication of GATA-4. Molecular and Cellular Endocrinology 263:181-189
Cai Z & Stocco C (2005) Expression and Regulation of Progestin Membrane Receptors in the Rat Corpus Luteum. Endocrinology. 146:5522-5532
Foyouzi N, Cai Z, Sugimoto Y, Stocco C (2005) Changes in the Expression of Steroidogenic and Antioxidant Genes in the Mouse Corpus Luteum during Luteolysis. Biology of Reproduction 72:1134-1141
Risk M, Shehu A, Mao J, Stocco C, Goldsmith LT, Bowen-Shauver JM, Gibori G. (2005) Cloning and characterization of a 5' regulatory region of the PRAP/17β HSD7 gene. Endocrinology 146:2807-2816.
Stocco C (2004) In Vivo and In Vitro Inhibition of cyp19 Gene Expression by Prostaglandin F2α in Murine Luteal Cells: Implication of GATA-4. Endocrinology 145:4957-4966.
Telleria CM, Goyeneche AA, Stocco C, Gibori G. (2004) Involvement of Nuclear Factor Kappa B in the Regulation of Rat Luteal Function: Potential Roles as Survival Factor and Inhibitor of 20α-Hydroxysteroid Dehydrogenase. J Mol Endocrinol. 32:365-383.
Stocco C, Djiane J & Gibori G. (2003) Prostaglandin F2α and Prolactin Signaling: PGF2α-mediated Inhibition of Prolactin Receptor Expression in the Corpus Luteum. Endocrinology 144:3301-3305.
Jirawatnotai, S, Moons DS, Stocco C, Franks R, Hales D, Gibori G & Kiyokawa H. (2003) The CDK Inhibitors p27Kip1 and p21Cip1 Cooperate to Restrict Proliferative Life Span in Differentiating Ovarian Cells. Journal of Biological Chemistry 278:17021-17027.
Stocco C, Lau L & Gibori G. (2002) A Calcium/Calmodulin Dependent Activation of ERK1/2 Mediates JunD Phosphorylation and Induction of nur77 and 20α-hsd Genes by PGF2α in Ovarian Cells. Journal of Biological Chemistry 277:3293-3302.
Stocco C, Calegari E & Gibori G. (2001) Opposite Effect of PRL and PGF2α on Rat Luteal Gene Expression as Reveled by Rat cDNA Expression Array. Endocrinology 142:4158-4161.
Stocco C, Chedrese J & Deis R. (2001) Luteal Expression of Cytochrome P450 Side-Chain Cleavage, Steroidogenic Acute Regulatory Protein, 3β-Hydroxysteroid Dehydrogenase, and 20α-Hydroxysteroid Dehydrogenase Genes in Late Pregnant Rats: Effect of LH and RU486. Biology of Reproduction 65:1114-1119.
Stocco C, Zhong L, Sugimoto Y, Ichikawa A, Lau L & Gibori G. (2000) Prostaglandin F2α Induced Expression of 20α-Hydroxysteroid Dehydrogenase Involves the Transcription Factor NUR77. Journal of Biological Chemistry 275(47):37202-37211.
Johnson M, Diaz H, Stocco C, Palomino A, Devoto L & Vega M. (1999) Antisteroidogenic Action of Nitric Oxide on Human Corpus Luteum In Vitro. Endocrine 11:31-36.
Telleria C, Stocco C, Stati A & Deis R. (1999) Progesterone Receptor is not Required for Progesterone Action in the Rat Corpus Luteum of Pregnancy. Steroids 64:760-766.
Stocco C & Deis R. (1999) Luteinizing Hormone Inhibits Conversion of Pregnenolone to Progesterone in Luteal Cells from Rats on Day 19 of Pregnancy. Biology of Reproduction 60:729-732.
Stocco C & Deis R. (1998) Participation of Intraluteal Prostaglandin F2α and Progesterone Level during LH Induced Luteolysis. Journal of Endocrinology 156:253-259.
Stocco C & Deis R. (1996) Luteolytic Effect of LH: Inhibition of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Activity in the Corpus Luteum of Late Pregnant Rats. Journal of Endocrinology 150:423-429.
Telleria C, Stocco C, Stati A, Rastrilla A, Carrizo D, Aguado L & Deis R. (1995) Dual Regulation of Luteal Progesterone Production by Androstenedione During Spontaneous and RU486-Induced Luteolysis in Pregnant Rats Journal of Steroid Biochemistry and Molecular Biology 55:385-393.
Telleria C, Stocco C & Deis R. (1995) Luteolytic Action of RU-486 Modulation of Luteal 3β-Hydroxysteroid Dehydrogenase and 20α-Hydroxysteroid Dehydrogenase Activities in Late Pregnant Rats. Journal of Steroid Biochemistry and Molecular Biology 52:567-573.
B. Book Chapters
Stocco C (2008) Hormonal and Molecular Regulation of the Cytochrome P450 Aromatase Gene Expression in the Ovary. In “The Molecules of Reproduction: An Introduction to Molecular Reproductive Biology” Chedrese J ed. Springer, New York, NY.
Stocco C (2008) The Molecular Control of Corpus Luteum Function. In “The Molecules of Reproduction: An Introduction to Molecular Reproductive Biology” Chedrese J ed. Springer, New York, NY
Bennett-Toomey, J, Stocco C (2018) GATA Regulation and Function During the Ovarian Life Cycle. Vitamins & Hormones 107:193-225.
Baumgarten SC and Stocco C. (2018) The Granulosa Cells. Encyclopedia of Reproduction.
Stocco C. (2018) Androgens and Ovary. Encyclopedia of Reproduction.
Hobeika E, Armouti M, Sudheer Kala H, Stocco C (2019) Ovarian Hormones.
C. Commentaries and other
Stocco C (2012) The long and short of the prolactin receptor; the corpus luteum needs them both! Biology of Reproduction 22:86-85.
Stocco C (2016) Follicle-stimulating Hormone (FSH) Phosphorylation of Protein Kinase B (AKT) Remains Controversial. The Journal of biological chemistry. 2016; 291(27):14385.