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The human physiological response to novel stent-graft deployment during thoracic endovascular aortic repair (TEVAR) is not well understood. There are no straightforward, reliable methods to model in-vivo conditions, and existing computational models do not provide adequate simulations.
To solve this problem we designed a Mock Flow Loop to provide a realistic in-vitro device to study the pressure changes at the branching arteries during a mock TEVAR procedure.
Why is TEVAR necessary?
Why is TEVAR necessary?
TEVAR is used to treat thoracic aortic aneurysms or TAA's (box B above, left). Aneurysms are weakened, bulging areas in the blood vessel wall that can expand until rupture causing severe bleeding and possibly death (some examples of aneurysm types above, right). There is an estimated 40% mortality rate for ruptured aneurysms.
What is TEVAR?
What is TEVAR?
There are different treatment methods for TAA repair, mainly open repair and TEVAR, with TEVAR being preferred due to improved outcomes.
TEVAR is a minimally invasive surgery approach that involves placing a stent graft to divert pressure away from weakened arterial walls. The surgeon makes an incision in the femoral artery (near the groin) where a catheter is inserted and progressed over a guidewire to the site of the aneurysm. A stent graft is deployed to create a sealed pathway for blood flow to reduce the risk of further expansion and rupture. An example graphic is shown above.
Our Goal
Our Goal
Our sponsor Dr. Barleben was concerned that there is a potential for blood flow to the brain to be blocked for a prolonged period during the procedure before full deployment of the graft
The branching arteries on top of the aorta (shown above) supply blood to the arms and brain, which can be dangerous if blocked. Certain aneurysm pathologies necessitate stent graft placement over these branches (as shown above). In these cases, an in-situ fenestration or hole is made in the main stent body, where a smaller branching stent is placed to allow blood flow to these occluded branches (see right). The goal is to confirm how blood pressure is affected during the procedure from partial deployment/stenting to full expansion and deployment.
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