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Caution!!
Caution!!
Washing the ORG layer with an additional few mLs of the KOH solution helps maximize the amount of acetaminophen recovered from the experiment...skipping that step will lead to product loss.
*Product loss: subtract 2 mg from ACE
Not to worry - next time!!
2_phenoxide salt_6M HCl_no PPT_cc.mp4- Acidic extraction of ACE
Tear pH paper into small squares (conserve!)
Determine the pH of the KOH – ACE AQ solution
Dip a stir rod into the solution then tap it on a small piece of pH paper on a watch glass
Obtain 10 mL of 6 M HCl in a labeled test tube - slowly add drop-wise to the ACE AQ solution
Swirl solution and take pH readings every 5-10 drops, until the solution is acidic (pH 2 or less)
Re-label the vial (Acidic ACE AQ)
2_phenoxide salt_acidicEXT1_cc.mp42. Add 15 mL EtOAc
2. Add 15 mL EtOAc
Acetaminophen does not precipitate out of the aqueous solution as well as aspirin – collect the product by acidic extraction:
Transfer the Acidic ACE AQ solution to the sep. funnel
Add 15 mL of EtOAc
Mix and vent for 3 minutes
Drain the aqueous and organic layers into separate flasks
Discuss:
What is happening at the molecular level – why does the Acidic ACE travel from the AQ layer to the ORG layer?
Is washing with 15 mL of ethyl acetate (or any solvent) at once just as effective as washing with 5 mL of ethyl acetate 3 times? (HINT: think about the surface area between the layers)
How do you want to proceed...
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