Publications

2023

Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside.

Ghonim MA, Boyd DF, Flerlage T, Thomas PG. J Clin Invest, 2023 Sep 1;133(17):e170499. doi: 10.1172/JCI170499. 

PMID: 37655660

2022

SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity.

Zhang W, Chua BY, Selva KJ, Kedzierski L, Ashhurst TM, Haycroft ER, Shoffner-Beck SK, Hensen L, Boyd DF, James F, Mouhtouris E, Kwong JC, Chua KYL, Drewett G, Copaescu A, Dobson JE, Rowntree LC, Habel JR, Allen LF, Koay HF, Neil JA, Gartner MJ, Lee CY, Andersson P, Khan SF, Blakeway L, Wisniewski J, McMahon JH, Vine EE, Cunningham AL, Audsley J, Thevarajan I, Seemann T, Sherry NL, Amanat F, Krammer F, Londrigan SL, Wakim LM, King NJC, Godfrey DI, Mackay LK, Thomas PG, Nicholson S, Arnold KB, Chung AW, Holmes NE, Smibert OC, Trubiano JA, Gordon CL, Nguyen THO, Kedzierska K. Nat Commun. 2022 May 19;13(1):2774 

PMID: 35589689

2021

 Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract.

Flerlage T, Boyd DF, Meliopoulos V, Thomas PG, Schultz-Cherry S.  Nat Rev Microbiol. 2021 Jul;19(7):425-441. 

PMID: 33824495

2020

Exuberant fibroblast activity compromises lung function via ADAMTS4.

Boyd DF, Allen EK, Randolph AG, Guo XJ, Weng Y, Sanders CJ, Bajracharya R, Lee NK, Guy CS, Vogel P, Guan W, Li Y, Liu X, Novak T, Newhams MM, Fabrizio TP, Wohlgemuth N, Mourani PM, Wight TN, Schultz-Cherry S, Cormier SA, Shaw-Saliba K, Pekosz A, Rothman RE, Chen KF, Yang Z, Webby RJ, Zhong N, Crawford JC, Thomas PG. Nature. 2020 Nov;587(7834):466-471.

PMID: 33116313

Necroptosis restricts influenza A virus as a stand-alone cell death mechanism.

Shubina M, Tummers B, Boyd DF, Zhang T, Yin C, Gautam A, Guo XJ, Rodriguez DA, Kaiser WJ, Vogel P, Green DR, Thomas PG, Balachandran S.. J Exp Med. 2020 Nov 2;217(11).

2018

 Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity.

Guo XJ, Dash P, Crawford JC, Allen EK, Zamora AE, Boyd DF, Duan S, Bajracharya R, Awad WA, Apiwattanakul N, Vogel P, Kanneganti TD, Thomas PG. Immunity. 2018 Sep 18;49(3):531-544.e6 

PMID: 30170813

2017

Towards integrating extracellular matrix and immunological pathways.  

Boyd DF, Thomas PG. Cytokine. 2017 Oct;98:79-86. 

PMID: 28325629

2016

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.

Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S. Cell Host Microbe. 2016 Nov 9;20(5):674-681. 

PMID: 27746097

Adapting SHIVs In Vivo Selects for Envelope-Mediated Interferon-α Resistance.

Boyd DF, Sharma A, Humes D, Cheng-Mayer C, Overbaugh J. PLoS Pathog. 2016 Jul;12(7): e1005727.

PMID: 27399306

2015

Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer.

Boyd DF, Peterson D, Haggarty BS, Jordan AP, Hogan MJ, Goo L, Hoxie JA, Overbaugh J. J Virol. 2015 Jan 15;89(2):894-907. 

PMID: 25378497